The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Propylthiouracil inhibits the conversion of l-thyroxine to l-triiodothyronine
Open accessAbstract
6-n-propylthiouracil (PTU) administered to male Sprague-Dawley rats maintained on 2 and 5 mug L-thyroxine (T(4))/100 g body weight resulted in a marked reduction in the rate of conversion of L-thyroxine to L-triiodothyronine (T(3)). These effects could not be ascribed to induced hypothyroidism since the group maintained on 5 mug T(4)/day had normal levels of liver mitochondrial alpha glycerophosphate dehydrogenase. In confirmation of previous studies, PTU also reduced the fractional rate of deiodination of T(3). These observations provide a possible explanation of the many published observations indicating that PTU antagonizes the tissue effects of T(4) but not of T(3). The data suggest that monodeiodination of T(4) but not of T(3) is essential before hormonal effects can be manifested at the cellular level.
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“Propylthiouracil (PTU) inhibits D1, explaining some of its therapeutic benefit in this setting (14).”
From Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement (2014) · cites this paper as [14]
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Citations
Cites
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Self-citationThe extrathyroidal conversion rate of thyroxine to triiodothyronine in normal man
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Research works printed but not linked: 1
- Oppenheimer, J. H., D. Koerner, H. L. Schwartz, and M. I. Surks. Specific nuclear triiodothyronine binding sites in rat liver and kidney. J. Clin. Endocrinol. Metab. In press.
Cited by
Sorted by citations
Jonklaas, J., Bianco, A. C., Bauer, A. J., Burman, K. D., Cappola, A. R., Celi, F. S., Cooper, D. S., Kim, B. W., Peeters, R. P., Rosenthal, M. S., et al. (2014) · Thyroid® · doi:10.1089/thy.2014.0028 · Cited by 1,928
“Propylthiouracil (PTU) inhibits D1, explaining some of its therapeutic benefit in this setting (14).”
Bianco, A. C., Salvatore, D., Gereben, B., Berry, M. J., & Larsen, P. R. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.1.0455 · Cited by 1,853
Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling1
Gereben, B., Zavacki, A. M., Ribich, S., Kim, B. W., Huang, S. A., Simonides, W. S., Zeöld, A., & Bianco, A. C. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0019 · Cited by 891
Type I iodothyronine deiodinase is a selenocysteine-containing enzyme
Berry, M. J., Banu, L., & Larsen, P. R. (1991) · Nature · doi:10.1038/349438a0 · Cited by 883
Larsen, P. R., Silva, J. E., & Kaplan, M. M. (1981) · Endocrine Reviews · doi:10.1210/edrv-2-1-87 · Cited by 546
Metadata
- Authors
- Oppenheimer, J. H., Schwartz, H. L., & Surks, M. I.
- Affiliations
- Albert Einstein College of Medicine (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1972-09-01
- Volume
- 51
- Issue
- 9
- Pages
- 2493-2497
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC292418
- OpenAlex
- W1758817371
- Cited by
- 258
- References
- 36
- Citations by year
- 2024: 3 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 6
- FWCI
- 16.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Health Research Council of the City of New York
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Chemical Analysis and Environmental Impact
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Keywords
- propylthiouracil, levothyroxine, triiodothyronine, T4 to T3 conversion, deiodination, thyroid hormone antagonism, alpha-glycerophosphate dehydrogenase, liver mitochondria, hypothyroidism
- MeSH terms
- Administration, Oral, Animals, Chromatography, Paper, Chromatography, Thin Layer, Glucosephosphate Dehydrogenase, Injections, Subcutaneous, Iodine Radioisotopes, Male, Mitochondria, Liver, Propylthiouracil, Thyroidectomy, Thyroxine, Triiodothyronine, Rats
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