The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Propylthiouracil inhibits the conversion of l-thyroxine to l-triiodothyronine
Open accessAbstract
6-n-propylthiouracil (PTU) administered to male Sprague-Dawley rats maintained on 2 and 5 mug L-thyroxine (T(4))/100 g body weight resulted in a marked reduction in the rate of conversion of L-thyroxine to L-triiodothyronine (T(3)). These effects could not be ascribed to induced hypothyroidism since the group maintained on 5 mug T(4)/day had normal levels of liver mitochondrial alpha glycerophosphate dehydrogenase. In confirmation of previous studies, PTU also reduced the fractional rate of deiodination of T(3). These observations provide a possible explanation of the many published observations indicating that PTU antagonizes the tissue effects of T(4) but not of T(3). The data suggest that monodeiodination of T(4) but not of T(3) is essential before hormonal effects can be manifested at the cellular level.
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“Propylthiouracil (PTU) inhibits D1, explaining some of its therapeutic benefit in this setting (14).”
From Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement (2014) · cites this paper as [14]
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Citations
Cites
Lee, Y., & Lardy, H. A. (1965) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)97593-9 · Cited by 632
Conversion of Thyroxine (T4) to triiodothyronine (T3) in athyreotic human subjects
Braverman, L. E., Ingbar, S. H., & Sterling, K. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106304 · Cited by 485
THE IDENTIFICATION OF 3:5:3'-L-TRIIODOTHYRONINE IN HUMAN PLASMA
Gross, J., & Pitt‐Rivers, R. (1952) · The Lancet · doi:10.1016/s0140-6736(52)91952-1 · Cited by 298
Role of Plasma Proteins in the Binding, Distribution and Metabolism of the Thyroid Hormones
Oppenheimer, J. H. (1968) · New England Journal of Medicine · doi:10.1056/nejm196805232782107 · Cited by 270
Self-citationThe extrathyroidal conversion rate of thyroxine to triiodothyronine in normal man
Pittman, C. S., Chambers, J. B., & Read, V. H. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106596 · Cited by 214
Quantitation of extrathyroidal conversion of l-thyroxine to 3,5,3′-triiodo-l-thyronine in the rat
Schwartz, H. L., Surks, M. I., & Oppenheimer, J. H. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106584 · Cited by 173
Self-citationConversion of Thyroxine to Triiodothyronine in Normal Human Subjects
Sterling, K., Brenner, M. A., & Newman, E. S. (1970) · Science · doi:10.1126/science.169.3950.1099 · Cited by 131
Specific Triiodothyronine Binding Sites in the Anterior Pituitary of the Rat
Schadlow, A. R., Surks, M. I., Schwartz, H. L., & Oppenheimer, J. H. (1972) · Science · doi:10.1126/science.176.4040.1252 · Cited by 101
Self-citationANTIGOITROGENIC AND CALORIGENIC ACTIVITIES OF THYROXINE ANALOGUES IN RATS1
STASILLI, N. R., Kroc, R. L., & Meltzer, R. I. (1959) · Endocrinology · doi:10.1210/endo-64-1-62 · Cited by 92
Oppenheimer, J. H., Schwartz, H. L., Shapiro, H. C., Bernstein, G. S., & Surks, M. I. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106301 · Cited by 85
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Research works printed but not linked: 1
- Oppenheimer, J. H., D. Koerner, H. L. Schwartz, and M. I. Surks. Specific nuclear triiodothyronine binding sites in rat liver and kidney. J. Clin. Endocrinol. Metab. In press.
Cited by
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Jonklaas, J., Bianco, A. C., Bauer, A. J., Burman, K. D., Cappola, A. R., Celi, F. S., Cooper, D. S., Kim, B. W., Peeters, R. P., Rosenthal, M. S., et al. (2014) · Thyroid® · doi:10.1089/thy.2014.0028 · Cited by 1,928
“Propylthiouracil (PTU) inhibits D1, explaining some of its therapeutic benefit in this setting (14).”
Bianco, A. C., Salvatore, D., Gereben, B., Berry, M. J., & Larsen, P. R. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.1.0455 · Cited by 1,853
Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling1
Gereben, B., Zavacki, A. M., Ribich, S., Kim, B. W., Huang, S. A., Simonides, W. S., Zeöld, A., & Bianco, A. C. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0019 · Cited by 891
Type I iodothyronine deiodinase is a selenocysteine-containing enzyme
Berry, M. J., Banu, L., & Larsen, P. R. (1991) · Nature · doi:10.1038/349438a0 · Cited by 883
Larsen, P. R., Silva, J. E., & Kaplan, M. M. (1981) · Endocrine Reviews · doi:10.1210/edrv-2-1-87 · Cited by 546
Metadata
- Authors
- Oppenheimer, J. H., Schwartz, H. L., & Surks, M. I.
- Affiliations
- Albert Einstein College of Medicine (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1972-09-01
- Volume
- 51
- Issue
- 9
- Pages
- 2493-2497
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC292418
- OpenAlex
- W1758817371
- Cited by
- 258
- References
- 36
- Citations by year
- 2024: 3 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 6
- FWCI
- 16.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Health Research Council of the City of New York
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Chemical Analysis and Environmental Impact
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Keywords
- propylthiouracil, levothyroxine, triiodothyronine, T4 to T3 conversion, deiodination, thyroid hormone antagonism, alpha-glycerophosphate dehydrogenase, liver mitochondria, hypothyroidism
- MeSH terms
- Administration, Oral, Animals, Chromatography, Paper, Chromatography, Thin Layer, Glucosephosphate Dehydrogenase, Injections, Subcutaneous, Iodine Radioisotopes, Male, Mitochondria, Liver, Propylthiouracil, Thyroidectomy, Thyroxine, Triiodothyronine, Rats
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