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Impaired Lymphocyte Function in Aged Humans
Open accessAbstract
The response of lymphocytes from young and old persons to phytohemagglutinin, pokeweed mitogen, or allogeneic lymphocytes has been measured. Lymphocytes from old persons incorporated significantly less tritiated thymidine as compared with lymphocytes from young persons when cultured with plant mitogens or allogeneic cells. The difference in observed lymphocyte reactivity could not be attributed to differences in culture conditions required for maximal transformation of lymphocytes from old or young subjects. The same percentage of thymus-derived and bone marrow-derived lymphocytes was found in the blood from old and young persons. The relationship of these findings to the decline of immunologic competence with age is discussed.
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Citations
Cited by
Age Influence on the Immune System
Makinodan, T., & Kay, M. M. B. (1980) · Advances in Immunology · doi:10.1016/s0065-2776(08)60047-4 · Cited by 699
AGEING, IMMUNE RESPONSE, AND MORTALITY
Roberts-Thomson, I., Youngchaiyud, U., Whittingham, S., & Mackay, I. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91755-3 · Cited by 477
Gillis, S., Kozak, R., Durante, M., & Weksler, M. E. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110143 · Cited by 472
Self-citationLymphocyte subset reference ranges in adult caucasians
Reichert, T., DeBruyère, M., Deneys, V., Tötterman, T., Lydyard, P., Yuksel, F., Chapel, H., Jewell, D., Van Hove, L., Linden, J., et al. (1991) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(91)90063-g · Cited by 301
Immune Responses to Varicella-Zoster in the Aged
Burke, B. L. (1982) · Archives of Internal Medicine · doi:10.1001/archinte.1982.00340150091017 · Cited by 295
Metadata
- Authors
- Weksler, M. E., & Hütteroth, T. H.
- Venue
- Journal of Clinical Investigation
- Published
- 1974-01-01
- Volume
- 53
- Issue
- 1
- Pages
- 99-104
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1963788239
- Cited by
- 343
- References
- 0
- FWCI
- 9.65
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
