The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Immune Responses to Varicella-Zoster in the Aged
Abstract
Skin test reactivity and in vitro lymphocyte stimulation responses to varicella-zoster (VZ) were examined in a large normal population ranging in age from 6 months to 93 years. Warning of cellular immunity, as examined by skin delayed hypersensitivity, began at age 40 years. Skin test responses to phytohemagglutinin, however, remained positive into the eighth decade of life. In vitro lymphocyte stimulation responses to VZ were usually positive (stimulation index greater than or equal to 2.5) until age 60 years, after which time levels, as observed with nonimmune individuals, were often demonstrated. Antibody levels, as measured by fluorescent antibody to membrane antigen, remained positive into the ninth and tenth decades of life. This was especially so with a history of reactivation (zoster) VZ infections, while skin test and in vitro responses were rarely positive in those individuals. This cellular, as contrasted with humoral, immunity decreases with advancing age, which may account for a propensity to reactivation of VZ virus.
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Cites
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Impaired Lymphocyte Function in Aged Humans
Weksler, M. E., & Hütteroth, T. H. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107565 · Cited by 343
THE NATURAL HISTORY OF HERPES ZOSTER
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Lymphocyte Phytohemagglutinin Responsiveness, Immunoglobulins and Autoantibodies in Aging Humans
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Selective decline in cellular immune response to varicella‐zoster in the elderly
Miller, A. E. (1980) · Neurology · doi:10.1212/wnl.30.6.582 · Cited by 277
Herpes Zoster-Varicella Infections and Lymphoma
GOFFINET, D. R., GLATSTEIN, E. J., & MERIGAN, T. C. (1972) · Annals of Internal Medicine · doi:10.7326/0003-4819-76-2-235 · Cited by 209
A 51Cr Microassay Technique for Cell-Mediated Immunity to Viruses
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Cited by
A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults
Oxman, M. N., Levin, M. J., Johnson, G. R., Schmader, K. E., Straus, S. E., Gelb, L. D., Arbeit, R. D., Simberkoff, M. S., Gershon, A. A., Davis, L. E., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051016 · Cited by 2,412
Beutner, K. R., Friedman, D. J., Forszpaniak, C., Andersen, P. L., & Wood, M. J. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.7.1546 · Cited by 613
The neurotropic herpes viruses: herpes simplex and varicella-zoster
Steiner, I., Kennedy, P. G., & Pachner, A. R. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70267-3 · Cited by 564
Structural and functional changes of normal aging skin
Fenske, N. A., & Lober, C. W. (1986) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(86)70208-9 · Cited by 535
Adjuvant system AS01: helping to overcome the challenges of modern vaccines
Didierlaurent, A. M., Laupèze, B., Di Pasquale, A., Hergli, N., Collignon, C., & Garçon, N. (2017) · Expert Review of Vaccines · doi:10.1080/14760584.2016.1213632 · Cited by 516
Metadata
- Authors
- Burke, B. L.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 1982-02-01
- Volume
- 142
- Issue
- 2
- Pages
- 291
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2092557034
- Cited by
- 295
- References
- 10
- FWCI
- 4.90
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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