Cited by 1,842Cardiac Ischemia and ReperfusionAcute Myocardial Infarction ResearchCardiac Imaging and Diagnostics

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The “No-Reflow” Phenomenon after Temporary Coronary Occlusion in the Dog

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Kloner, Robert A., Ganote, Charles E., Jennings, Robert B.·1974·Journal of Clinical Investigation

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Abstract

The role of microvascular damage in the genesis of the "no-reflow" phenomenon was investigated in the left ventricular myocardium of dogs subjected to temporary occlusions of a major coronary artery for 40 and 90 min. Intravenous carbon black or thioflavin S (a fluorescent vital stain for endothelium) were used to demonstrate the distribution of coronary arterial flow in control and damaged myocardium. These tracers were injected simultaneously with release of the coronary occlusion or after 5 or 20 min of reflow of coronary arterial blood. After 40 min of ischemia plus arterial reperfusion, usually the tracers were evenly distributed throughout the damaged tissue at each time of reperfusion. On the other hand, when reflow was allowed after 90 min of ischemia, portions of the inner half of damaged myocardium were not penetrated by the tracers. Electron microscopic study of this poorly perfused tissue revealed severe capillary damage; endothelial cells with large intraluminal protrusions and decreased pinocytic vesicles were common. Also, occasional intraluminal fibrin thrombi were noted, as well as extravascular fibrin deposits and erythrocytes. Myocardial cells were swollen in both poorly perfused and well-perfused irreversibly injured tissue. Contraction bands and mitochondrial Ca(2+) accumulation were prominent features of irreversible injury with reflow at 40 min but were not noted after 90 min of ischemia in areas with poor perfusion. These results suggest that 40 min of ischemia were tolerated by the capillary bed of the dog heart without serious capillary damage or perfusion defects, but that 90 min of ischemic injury was associated with the "no-reflow" phenomenon, i.e., failure to achieve uniform reperfusion. This failure of reflow was associated with extensive capillary damage and myocardial cell swelling. Death of severely ischemic myocardial cells in this model occurs before the onset of capillary damage and the no-reflow phenomenon.

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Some sources of error in measuring regional blood flow with radioactive microspheres.
Buckberg, G. D., Luck, J. C., Payne, D. B., Hoffman, J. I. E., Archie, J. P., & Fixler, D. E. (1971) · Journal of Applied Physiology · doi:10.1152/jappl.1971.31.4.598 · Cited by 1,132
Myocardial calcium and magnesium in acute ischemic injury.
Shen, A. C., & Jennings, R. B. (1972) · PubMed · Cited by 629
Self-citation
Kinetics of calcium accumulation in acute myocardial ischemic injury.
Shen, A. C., & Jennings, R. B. (1972) · PubMed Central · Cited by 507
Self-citation
The Role of Cell Swelling in Ischemic Renal Damage and the Protective Effect of Hypertonic Solute
Flores, J., DiBona, D. R., Beck, C. H., & Leaf, A. (1972) · Journal of Clinical Investigation · doi:10.1172/jci106781 · Cited by 452
Effect of a transient period of ischemia on myocardial cells. II. Fine structure during the first few minutes of reflow.
Kloner, R. A., Ganote, C. E., Whalen, D. A., & Jennings, R. B. (1974) · PubMed Central · Cited by 430
Self-citation
Effect of a transient period of ischemia on myocardial cells. I. Effects on cell volume regulation.
Whalen, D. A., Hamilton, D. G., Ganote, C. E., & Jennings, R. B. (1974) · PubMed Central · Cited by 357
Self-citation
Cerebral ischemia. III. Vascular changes.
Chiang, J., Kowada, M., Ames, A., Wright, R., & Majno, G. (1968) · PubMed Central · Cited by 336
Blood Supply of the Myocardium after Temporary Coronary Occlusion
Krug, A., de Rochemont, W. D. M., & Korb, G. (1966) · Circulation Research · doi:10.1161/01.res.19.1.57 · Cited by 288
Cell Swelling
Leaf, A. (1973) · Circulation · doi:10.1161/01.cir.48.3.455 · Cited by 269
A COMPARATIVE STUDY OF THE FINE STRUCTURE OF NORMAL AND ISCHEMIC DOG MYOCARDIUM WITH SPECIAL REFERENCE TO EARLY CHANGES FOLLOWING TEMPORARY OCCLUSION OF A CORONARY ARTERY.
Herdson, P. B., Sommers, H. M., & Jennings, R. B. (1965) · PubMed · Cited by 219
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Kloner, R. A., C. E. Ganote, K. A. Reimer, and R. B. Jennings. 1974. Coronary flow during acute myocardial ischemia. Fed. Proc. 33: 592. (Abstr.)
Rasmussen, M. M., K. A. Reimer, and R. B. Jennings. 1974. Propranolol therapy in experimental myocardial ischemia. Fed. Proc. 33: 591. (Abstr.) 1508

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Abbo, K. M., Dooris, M., Glazier, S., O’Neill, W. W., Byrd, D., Grines, C. L., & Safian, R. D. (1995) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)80410-x · Cited by 286
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Marchant, D., Boyd, J. H., Lin, D. C., Granville, D. J., Garmaroudi, F. S., & McManus, B. M. (2012) · Circulation Research · doi:10.1161/circresaha.111.243170 · Cited by 289
Effect of Microvascular Obstruction and Intramyocardial Hemorrhage by CMR on LV Remodeling and Outcomes After Myocardial Infarction
Hamirani, Y. S., Wong, A., Kramer, C. M., & Salerno, M. (2014) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2014.06.012 · Cited by 274
The role of inflammation in vascular diseases
Sullivan, G. W., Sarembock, I. J., & Linden, J. M. (2000) · Journal of Leukocyte Biology · doi:10.1002/jlb.67.5.591 · Cited by 270
Historical Perspective on the Pathology of Myocardial Ischemia/Reperfusion Injury
Jennings, R. B. (2013) · Circulation Research · doi:10.1161/circresaha.113.300987 · Cited by 268
Self-citation
Plaque Gruel of Atheromatous Coronary Lesion May Contribute to the No-Reflow Phenomenon in Patients With Acute Coronary Syndrome
Kotani, J., Nanto, S., Mintz, G. S., Kitakaze, M., Ohara, T., Morozumi, T., Nagata, S., & Hori, M. (2002) · Circulation · doi:10.1161/01.cir.0000030189.27175.4e · Cited by 265
The coronary circulation in acute myocardial ischaemia/reperfusion injury: a target for cardioprotection
Hausenloy, D. J., Chilian, W. M., Crea, F., Davidson, S. M., Ferdinandy, P., García‐Dorado, D., van Royen, N., Schulz, R., & Heusch, G. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy286 · Cited by 271
Pathophysiology and diagnosis of coronary microvascular dysfunction in ST-elevation myocardial infarction
Konijnenberg, L. S. F., Damman, P., Duncker, D. J., Kloner, R. A., Nijveldt, R., van Geuns, R., Berry, C., Riksen, N. P., Escaned, J., & van Royen, N. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz301 · Cited by 267
Self-citation
No-Reflow Phenomenon and Lesion Morphology in Patients With Acute Myocardial Infarction
Tanaka, A., Kawarabayashi, T., Nishibori, Y., Sano, T., Nishida, Y., Fukuda, D., Shimada, K., & Yoshikawa, J. (2002) · Circulation · doi:10.1161/01.cir.0000015697.59592.07 · Cited by 261
Beneficial Effect of Intracoronary Verapamil on Microvascular and Myocardial Salvage in Patients With Acute Myocardial Infarction
Taniyama, Y., Ito, H., Iwakura, K., Masuyama, T., Hori, M., Takiuchi, S., Nishikawa, N., Higashino, Y., Fujii, K., & Minamino, T. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00277-5 · Cited by 257
Shifting the open-artery hypothesis downstream: the quest for optimal reperfusion
Roe, M. T., Ohman, E. M., Maas, A., Christenson, R. H., Mahaffey, K. W., Granger, C. B., Harrington, R. A., Califf, R. M., & Krucoff, M. W. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)01101-3 · Cited by 257
Management of No-Reflow Phenomenon in the Catheterization Laboratory
Rezkalla, S. H., Stankowski, R. V., Hanna, J. M., & Kloner, R. A. (2017) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2016.11.059 · Cited by 263
Self-citation
Coronary microvascular obstruction: the new frontier in cardioprotection
Heusch, G. (2019) · Basic Research in Cardiology · doi:10.1007/s00395-019-0756-8 · Cited by 255
Left ventricular support by Catheter-Mountedaxial flow pump reduces infarct size
Meyns, B. P., Stoliński, J., Leunens, V., Verbeken, E. K., & Flameng, W. J. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00084-6 · Cited by 254
Inflammatory responses to ischemia, and reperfusion in skeletal muscle
Gute, D. C., Ishida, T., Yarimizu, K., & Korthius, R. J. (1998) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006832207864 · Cited by 252
Emotional intelligence in the workplace: exploring its effects on occupational stress and health outcomes in human service workers.
Ogińska-Bulik, N. J. (2005) · PubMed · Cited by 250
Incidence and Outcomes of No-Reflow Phenomenon During Percutaneous Coronary Intervention Among Patients With Acute Myocardial Infarction
Harrison, R. W., Aggarwal, A., Ou, F., Klein, L. W., Rumsfeld, J. S., Roe, M. T., & Wang, T. Y. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.09.015 · Cited by 248
Early Contrast-Enhanced MRI Predicts Late Functional Recovery After Reperfused Myocardial Infarction
Rogers, W. J., Kramer, C. M., Geskin, G., Hu, Y.-L., Theobald, T. M., Vido, D. A., Petruolo, S., & Reichek, N. (1999) · Circulation · doi:10.1161/01.cir.99.6.744 · Cited by 244
Cardiovascular magnetic resonance physics for clinicians: part II
Biglands, J. D., Radjenovic, A., & Ridgway, J. P. (2012) · Journal of Cardiovascular Magnetic Resonance · doi:10.1186/1532-429x-14-66 · Cited by 241
Neutrophils as potential participants in acute myocardial ischemia: Relevance to reperfusion
Mehta, J. L., Nichols, W. W., & Mehta, P. (1988) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(88)90297-5 · Cited by 241
Effect of interventions in salvaging left ventricular function in acute myocardial infarction: A study of intracoronary streptokinase
Sheehan, F. H., Mathey, D. G., Schofer, J. J., Krebber, H.-J., & Dodge, H. T. (1983) · The American Journal of Cardiology · doi:10.1016/0002-9149(83)90002-4 · Cited by 240
No-reflow phenomenon and prognosis in patients with acute myocardial infarction
Ito, H. (2006) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0632 · Cited by 238
Relation between ST-segment changes and myocardial perfusion evaluated by myocardial contrast echocardiography in patients with acute myocardial infarction treated with direct angioplasty
Santoro, G. M., Valenti, R., Buonamici, P., Bolognese, L., Cerisano, G., Moschi, G., Trapani, M., Antoniucci, D., & Fazzini, P. F. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00508-6 · Cited by 238
Evidence for a reversible oxygen radical-mediated component of reperfusion injury: reduction by recombinant human superoxide dismutase administered at the time of reflow.
Ambrosio, G., Weisfeldt, M. L., Jacobus, W. E., & Flaherty, J. T. (1987) · Circulation · doi:10.1161/01.cir.75.1.282 · Cited by 238
The Coronary Circulation as a Target of Cardioprotection
Heusch, G. (2016) · Circulation Research · doi:10.1161/circresaha.116.308640 · Cited by 233
A Pilot Study of Rapid Cooling by Cold Saline and Endovascular Cooling Before Reperfusion in Patients With ST-Elevation Myocardial Infarction
Götberg, M., Olivecrona, G. K., Koul, S. M., Carlsson, M., Engblom, H., Ugander, M., van der Pals, J., Algotsson, L., Arheden, H., & Erlinge, D. (2010) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.110.957902 · Cited by 231
No-reflow phenomenon in the heart and brain
Kloner, R. A., King, K. S., & Harrington, M. G. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00183.2018 · Cited by 238
Self-citation

Authors: Kloner, R. A., Ganote, C. E., & Jennings, R. B.
Affiliations: Northwestern University (US)
ORCID: Kloner, Robert A.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1974-12-01
Volume: 54
Issue: 6
Pages: 1496-1508
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci107898
PMC: PMC301706
OpenAlex: W2140233303
Cited by: 1,842
References: 25
Citations by year: 2026: 21 · 2025: 25 · 2024: 28 · 2023: 30 · 2022: 37 · 2021: 37 · 2020: 30 · 2019: 44 · 2018: 36 · 2017: 35 · 2016: 53 · 2015: 53 · 2014: 43 · 2013: 46 · 2012: 55
FWCI: 12.94
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart and Lung Institute
National Institutes of Health
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Keywords: no-reflow phenomenon, myocardial ischemia, myocardial reperfusion, capillary damage, irreversible myocardial injury, coronary artery occlusion, thioflavin S, fibrin thrombi, mitochondrial calcium accumulation, contraction bands, ischemic tolerance
MeSH terms: Animals, Capillaries, Carbon, Coronary Circulation, Coronary Disease, Coronary Vessels, Dogs, Erythrocytes, Female, Fluorescence, Fluorescent Dyes, Ischemia, Male, Microcirculation, Microscopy, Electron, Mitochondria, Muscle, Myocardium, Papillary Muscles, Staining and Labeling, Thiazoles, Time Factors

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The “No-Reflow” Phenomenon after Temporary Coronary Occlusion in the Dog

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