Cited by 1,842Cardiac Ischemia and ReperfusionAcute Myocardial Infarction ResearchCardiac Imaging and Diagnostics

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The “No-Reflow” Phenomenon after Temporary Coronary Occlusion in the Dog

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Kloner, Robert A., Ganote, Charles E., Jennings, Robert B.·1974·Journal of Clinical Investigation

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Abstract

The role of microvascular damage in the genesis of the "no-reflow" phenomenon was investigated in the left ventricular myocardium of dogs subjected to temporary occlusions of a major coronary artery for 40 and 90 min. Intravenous carbon black or thioflavin S (a fluorescent vital stain for endothelium) were used to demonstrate the distribution of coronary arterial flow in control and damaged myocardium. These tracers were injected simultaneously with release of the coronary occlusion or after 5 or 20 min of reflow of coronary arterial blood. After 40 min of ischemia plus arterial reperfusion, usually the tracers were evenly distributed throughout the damaged tissue at each time of reperfusion. On the other hand, when reflow was allowed after 90 min of ischemia, portions of the inner half of damaged myocardium were not penetrated by the tracers. Electron microscopic study of this poorly perfused tissue revealed severe capillary damage; endothelial cells with large intraluminal protrusions and decreased pinocytic vesicles were common. Also, occasional intraluminal fibrin thrombi were noted, as well as extravascular fibrin deposits and erythrocytes. Myocardial cells were swollen in both poorly perfused and well-perfused irreversibly injured tissue. Contraction bands and mitochondrial Ca(2+) accumulation were prominent features of irreversible injury with reflow at 40 min but were not noted after 90 min of ischemia in areas with poor perfusion. These results suggest that 40 min of ischemia were tolerated by the capillary bed of the dog heart without serious capillary damage or perfusion defects, but that 90 min of ischemic injury was associated with the "no-reflow" phenomenon, i.e., failure to achieve uniform reperfusion. This failure of reflow was associated with extensive capillary damage and myocardial cell swelling. Death of severely ischemic myocardial cells in this model occurs before the onset of capillary damage and the no-reflow phenomenon.

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Some sources of error in measuring regional blood flow with radioactive microspheres.
Buckberg, G. D., Luck, J. C., Payne, D. B., Hoffman, J. I. E., Archie, J. P., & Fixler, D. E. (1971) · Journal of Applied Physiology · doi:10.1152/jappl.1971.31.4.598 · Cited by 1,132
Myocardial calcium and magnesium in acute ischemic injury.
Shen, A. C., & Jennings, R. B. (1972) · PubMed · Cited by 629
Self-citation
Kinetics of calcium accumulation in acute myocardial ischemic injury.
Shen, A. C., & Jennings, R. B. (1972) · PubMed Central · Cited by 507
Self-citation
The Role of Cell Swelling in Ischemic Renal Damage and the Protective Effect of Hypertonic Solute
Flores, J., DiBona, D. R., Beck, C. H., & Leaf, A. (1972) · Journal of Clinical Investigation · doi:10.1172/jci106781 · Cited by 452
Effect of a transient period of ischemia on myocardial cells. II. Fine structure during the first few minutes of reflow.
Kloner, R. A., Ganote, C. E., Whalen, D. A., & Jennings, R. B. (1974) · PubMed Central · Cited by 430
Self-citation
Effect of a transient period of ischemia on myocardial cells. I. Effects on cell volume regulation.
Whalen, D. A., Hamilton, D. G., Ganote, C. E., & Jennings, R. B. (1974) · PubMed Central · Cited by 357
Self-citation
Cerebral ischemia. III. Vascular changes.
Chiang, J., Kowada, M., Ames, A., Wright, R., & Majno, G. (1968) · PubMed Central · Cited by 336
Blood Supply of the Myocardium after Temporary Coronary Occlusion
Krug, A., de Rochemont, W. D. M., & Korb, G. (1966) · Circulation Research · doi:10.1161/01.res.19.1.57 · Cited by 288
Cell Swelling
Leaf, A. (1973) · Circulation · doi:10.1161/01.cir.48.3.455 · Cited by 269
A COMPARATIVE STUDY OF THE FINE STRUCTURE OF NORMAL AND ISCHEMIC DOG MYOCARDIUM WITH SPECIAL REFERENCE TO EARLY CHANGES FOLLOWING TEMPORARY OCCLUSION OF A CORONARY ARTERY.
Herdson, P. B., Sommers, H. M., & Jennings, R. B. (1965) · PubMed · Cited by 219
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Kloner, R. A., C. E. Ganote, K. A. Reimer, and R. B. Jennings. 1974. Coronary flow during acute myocardial ischemia. Fed. Proc. 33: 592. (Abstr.)
Rasmussen, M. M., K. A. Reimer, and R. B. Jennings. 1974. Propranolol therapy in experimental myocardial ischemia. Fed. Proc. 33: 591. (Abstr.) 1508

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Iliceto, S., Galiuto, L., Marchese, A., Cavallari, D., Colonna, P., Biasco, G., & RIZZON, P. (1996) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)89334-4 · Cited by 96
Assessment of Reperfused Acute Myocardial Infarction with Two-Phase Contrast-enhanced Helical CT: Prediction of Left Ventricular Function and Wall Thickness
Koyama, Y., Matsuoka, H., Mochizuki, T., Higashino, H., Kawakami, H., Nakata, S., Aono, J., Ito, T., Naka, M., Ohashi, Y., et al. (2005) · Radiology · doi:10.1148/radiol.2353030441 · Cited by 96
Impact of Ultrasound Attenuation and Plaque Rupture as Detected by Intravascular Ultrasound on the Incidence of No-Reflow Phenomenon After Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction
Endo, M., Hibi, K., Shimizu, T., Komura, N., Kusama, I., Otsuka, F., Mitsuhashi, T., Iwahashi, N., Okuda, J., Tsukahara, K., et al. (2010) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2010.01.015 · Cited by 95
A role for pericytes in coronary no-reflow
O’Farrell, F. M., & Attwell, D. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.58 · Cited by 95
Reversal of “no reflow” during vein graft stenting using high velocity boluses of intracoronary adenosine
Fischell, T. A., Carter, A. J., Foster, M. T., Hempsall, K., DeVries, J. J., Kim, D. H., & Kloostra, A. (1998) · Catheterization and Cardiovascular Diagnosis · doi:10.1002/(sici)1097-0304(199812)45:4 · Cited by 95
Postconditioning attenuates no-reflow in STEMI patients
Mewton, N., Thibault, H., Roubille, F., Lairez, O., Rioufol, G., Sportouch, C., Sanchez, I., Bergerot, C., Cung, T. T., Finet, G., et al. (2013) · Basic Research in Cardiology · doi:10.1007/s00395-013-0383-8 · Cited by 94
Coronary microembolization
Skyschally, A., Leineweber, K., Gres, P., Haude, M., Erbel, R. M., & Heusch, G. (2006) · Basic Research in Cardiology · doi:10.1007/s00395-006-0616-1 · Cited by 95
Quantitative analysis of contraction band and coagulation necrosis after ischemia and reperfusion in the porcine heart.
Miyazaki, S., Fujiwara, H., Onodera, T., Kihara, Y., Matsuda, M., Wu, D. J., Nakamura, Y., Kumada, T., Sasayama, S., & Kawai, C. (1987) · Circulation · doi:10.1161/01.cir.75.5.1074 · Cited by 94
Coronary Flow Velocity Pattern Immediately After Percutaneous Coronary Intervention as a Predictor of Complications and In-Hospital Survival After Acute Myocardial Infarction
Yamamuro, A., Akasaka, T., Tamita, K., Yamabe, K., Katayama, M., Takagi, T., & Morioka, S. (2002) · Circulation · doi:10.1161/01.cir.0000043022.44032.77 · Cited by 93
Quantitative correlation between cell swelling and necrosis in myocardial ischemia in dogs.
DiBona, D. R., & Powell, W. J. (1980) · Circulation Research · doi:10.1161/01.res.47.5.653 · Cited by 93
Role of leukocytes in coronary vascular endothelial injury due to ischemia and reperfusion.
Sheridan, F. M., Dauber, I. M., McMurtry, I. F., Lesnefsky, E. J., & Horwitz, L. D. (1991) · Circulation Research · doi:10.1161/01.res.69.6.1566 · Cited by 93
Elevated Troponin I Level on Admission Is Associated With Adverse Outcome of Primary Angioplasty in Acute Myocardial Infarction
Matetzky, S., Sharir, T., Domingo, M. T., Noč, M., Chyu, K., Kaul, S., Eigler, N. L., Shah, P. K., & Cercek, B. (2000) · Circulation · doi:10.1161/01.cir.102.14.1611 · Cited by 92
Effects of staged versus sudden reperfusion after acute coronary occlusion in the dog
Yamazaki, S., Fujibayashi, Y., Rajagopalan, R. E., Meerbaum, S., & Corday, E. (1986) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(86)80466-1 · Cited by 92
The relationship of ischemic contracture to vascular reperfusion in the isolated rat heart
Humphrey, S. (1980) · Journal of Molecular and Cellular Cardiology · doi:10.1016/0022-2828(80)90124-8 · Cited by 92
Effect of angiotensin-induced hypertension on rat coronary arteries and myocardium.
Giacomelli, F., Anversa, P., & Wiener, J. (1976) · PubMed Central · Cited by 92
Progressive coronary vasoconstriction during relative ischemia in canine myocardium.
Gorman, M. W., & SPARKS, H. V. (1982) · Circulation Research · doi:10.1161/01.res.51.4.411 · Cited by 92
Coronary microvascular dysfunction after myocardial infarction: increased coronary zero flow pressure both in the infarcted and in the remote myocardium is mainly related to left ventricular filling pressure
Herck, P. L. V., CARLIER, S. G., Claeys, M. J., Haine, S. E. F., Gorissen, P., Miljoen, H., Bosmans, J. M., & Vrints, C. J. M. (2007) · Heart · doi:10.1136/hrt.2006.100818 · Cited by 91
Ischemia-Induced Interleukin-8 Release After Human Heart Transplantation
Öz, M. C., Liao, H., Naka, Y., Seldomridge, A., Becker, D. N., Michler, R. E., Smith, C. R., Rose, E. A., Stern, D. M., & Pinsky, D. J. (1995) · Circulation · doi:10.1161/01.cir.92.9.428 · Cited by 91
Protection by superoxide dismutase from myocardial dysfunction and attenuation of vasodilator reserve after coronary occlusion and reperfusion in dog.
Mehta, J. L., Nichols, W. W., Donnelly, W. H., Lawson, D. L., Thompson, L. V., ter Riet, M., & Saldeen, T. G. P. (1989) · Circulation Research · doi:10.1161/01.res.65.5.1283 · Cited by 91
The treatment of acute myocardial infarction: the Past, the Present, and the Future
D, E. B. M. (2012) · European Heart Journal Acute Cardiovascular Care · doi:10.1177/2048872612438026 · Cited by 90
The coronary circulation in cardioprotection: more than just one confounder
Heusch, G., Kleinbongard, P., Skyschally, A., Levkau, B., Schulz, R., & Erbel, R. M. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr271 · Cited by 90
Reduction of infarct size with intracoronary perfluorochemical in a canine preparation of reperfusion.
Forman, M. B., Bingham, S. E., Kopelman, H. A., Wehr, C., Sandler, M. P., Kolodgie, F. D., VAUGHN, W. K., Friesinger, G. C., & Virmani, R. (1985) · Circulation · doi:10.1161/01.cir.71.5.1060 · Cited by 90
Myocardial contractile actions of endothelin-1 in rat and rabbit papillary muscles. Role of endocardial endothelium.
Li, K., Stewart, D. J., & Rouleau, J. L. (1991) · Circulation Research · doi:10.1161/01.res.69.2.301 · Cited by 89
Cardiac MRI to Visualize Myocardial Damage after ST-Segment Elevation Myocardial Infarction: A Review of Its Histologic Validation
Beijnink, C. W. H., van der Hoeven, N. W., Konijnenberg, L. S. F., Kim, R. J., Bekkers, S. C. A. M., Kloner, R. A., Everaars, H., Messaoudi, S. E., van Rossum, A. C., van Royen, N., et al. (2021) · Radiology · doi:10.1148/radiol.2021204265 · Cited by 88
Self-citation
Combined adenosine and lidocaine administration limits myocardial reperfusion injury.
Homeister, J. W., Hoff, P. T., Fletcher, D. D., & Lucchesi, B. R. (1990) · Circulation · doi:10.1161/01.cir.82.2.595 · Cited by 88
Predictive value of reactive hyperemic response on reperfusion on recovery of regional myocardial function after coronary angioplasty in acute myocardial infarction.
Suryapranata, H., Zijlstra, F., MacLeod, D. C., van den Brand, M., de Feyter, P. J., & Serruys, P. W. J. C. (1994) · Circulation · doi:10.1161/01.cir.89.3.1109 · Cited by 87
CMR Native T1 Mapping Allows Differentiation of Reversible Versus Irreversible Myocardial Damage in ST-Segment–Elevation Myocardial Infarction
Liu, D., Borlotti, A., Viliani, D., Jerosch‐Herold, M., Alkhalil, M., Maria, G. L. D., Fahrni, G., Dawkins, S., Wijesurendra, R. S., Francis, J. M., et al. (2017) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.116.005986 · Cited by 86
Mesenchymal stromal cells for improvement of cardiac function following acute myocardial infarction: a matter of timing
Barrère‐Lemaire, S., Vincent, A., Jørgensen, C., Piot, C. A., Nargeot, J., & Djouad, F. (2023) · Physiological Reviews · doi:10.1152/physrev.00009.2023 · Cited by 88
Mechanical left ventricular unloading prior to reperfusion reduces infarct size in a canine infarction model
Achour, H. C., Boccalandro, F., Felli, P., Amirian, J. H., Uthman, M. O., Buja, L. M., & Smalling, R. W. (2005) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.20271 · Cited by 86
Beneficial Effects of RheothRx Injection in Patients Receiving Thrombolytic Therapy for Acute Myocardial Infarction
Schaer, G. L., Spaccavento, L. J., Browne, K. F., Krueger, K. A., Krichbaum, D. W., Phelan, J. M., Fletcher, W. O., Grines, C. L., Edwards, S., Jolly, M. K., et al. (1996) · Circulation · doi:10.1161/01.cir.94.3.298 · Cited by 86
Regional redistribution of myocardial blood flow after coronary occlusion and reperfusion in the conscious dog
White, F. C., Sanders, M., & Bloor, C. M. (1978) · The American Journal of Cardiology · doi:10.1016/0002-9149(78)90905-0 · Cited by 86
Relation Between the Assessment of Microvascular Injury by Cardiovascular Magnetic Resonance and Coronary Doppler Flow Velocity Measurements in Patients With Acute Anterior Wall Myocardial Infarction
Hirsch, A., Nijveldt, R., Haeck, J. D. E., Beek, A. M., Koch, K. T., Henriques, J. P. S., van der Schaaf, R. J., Vis, M. M., Baan, J., de Winter, R. J., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.01.064 · Cited by 85

Authors: Kloner, R. A., Ganote, C. E., & Jennings, R. B.
Affiliations: Northwestern University (US)
ORCID: Kloner, Robert A.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1974-12-01
Volume: 54
Issue: 6
Pages: 1496-1508
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci107898
PMC: PMC301706
OpenAlex: W2140233303
Cited by: 1,842
References: 25
Citations by year: 2026: 21 · 2025: 25 · 2024: 28 · 2023: 30 · 2022: 37 · 2021: 37 · 2020: 30 · 2019: 44 · 2018: 36 · 2017: 35 · 2016: 53 · 2015: 53 · 2014: 43 · 2013: 46 · 2012: 55
FWCI: 12.94
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart and Lung Institute
National Institutes of Health
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Keywords: no-reflow phenomenon, myocardial ischemia, myocardial reperfusion, capillary damage, irreversible myocardial injury, coronary artery occlusion, thioflavin S, fibrin thrombi, mitochondrial calcium accumulation, contraction bands, ischemic tolerance
MeSH terms: Animals, Capillaries, Carbon, Coronary Circulation, Coronary Disease, Coronary Vessels, Dogs, Erythrocytes, Female, Fluorescence, Fluorescent Dyes, Ischemia, Male, Microcirculation, Microscopy, Electron, Mitochondria, Muscle, Myocardium, Papillary Muscles, Staining and Labeling, Thiazoles, Time Factors

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The “No-Reflow” Phenomenon after Temporary Coronary Occlusion in the Dog

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