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Effect of osteoclast activating factor from human leukocytes on bone metabolism.
Open accessAbstract
The effects of osteoclast activating factor (OAF) released by normal human peripheral blood leukocytes cultured with phytohemagglutinin have been examined in organ culture. Like parathyroid hormone (PTH), OAF causes a rapid increased in the release of previously incorporated 45Ca from fetal rat bone after brief or continuous exposure; the bones also lose stable calcium and collagen content. The resorption response to OAF also resembles that of PTH in having a steep dose response curve and being only transiently inhibited by calcitonin and partially inhibited by increasing medium phosphate concentration. OAF-stimulated resorption was inhibited more effectively by cortisol than was PTH stimulation. The response to maximally effective doses of OAF was not enhanced by PTH or prostaglandin E2, but submaximal doses gave additive effects. Both OAF and PTH inhibit collagen synthesis in fetal rat calvaria at the concentrations that stimulate bone resorption.
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“locally produced cytokines such as IL-1 and prostaglandins such as prostaglandin E 2 (PGE 2 ) can affect bone”
From Pathogenesis of osteoporosis: concepts, conflicts, and prospects (2005) · cites this paper as [82]
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Citations
Cites
Peterkofsky, B., & Diegelmann, R. F. (1971) · Biochemistry · doi:10.1021/bi00782a009 · Cited by 1,389
Prostaglandins: Stimulation of Bone Resorption in Tissue Culture
KLEIN, D. C., & RAISZ, L. G. (1970) · Endocrinology · doi:10.1210/endo-86-6-1436 · Cited by 969
Self-citationEvidence for the Secretion of an Osteoclast Stimulating Factor in Myeloma
Mundy, G. R., Raisz, L. G., Cooper, R. A., Schechter, G. P., & Salmon, S. E. (1974) · New England Journal of Medicine · doi:10.1056/nejm197411142912001 · Cited by 670
Self-citationBone resorbing activity in supernatant fluid from cultured human peripheral blood leukocytes
Horton, J. E., Raisz, L. G., Simmons, H. A., Oppenheim, J. J., & Mergenhagen, S. E. (1972) · Science · doi:10.1126/science.177.4051.793 · Cited by 565
Self-citationRaisz, L. G. (1969) · Endocrinology · doi:10.1210/endo-85-3-446 · Cited by 411
Self-citationBone-Resorbing Activity in Supernatants from Lymphoid Cell Lines
Mundy, G. R., Luben, R. A., Raisz, L. G., Oppenheim, J. J., & Buell, D. N. (1974) · New England Journal of Medicine · doi:10.1056/nejm197404182901601 · Cited by 293
Self-citationGrowth of embryonic avian and mammalian tibiae on a relatively simple chemically defined medium
Biggers, J. D., Gwatkin, R. B. L., & Heyner, S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90305-6 · Cited by 246
Inhibition of bone collagen synthesis by prostaglandin E2 in organ culture
Raisz, L. G., & Koolemans‐Beynen, A. (1974) · Prostaglandins · doi:10.1016/0090-6980(74)90113-0 · Cited by 176
Self-citationComplement-Dependent Stimulation of Prostaglandin Synthesis and Bone Resorption
Raisz, L. G., Sandberg, A. L., Goodson, J. M., Simmons, H. A., & Mergenhagen, S. E. (1974) · Science · doi:10.1126/science.185.4153.789 · Cited by 172
Self-citationWener, J. A., Gorton, S., & Raisz, L. G. (1972) · Endocrinology · doi:10.1210/endo-90-3-752 · Cited by 152
Self-citation
Cited by
Sorted by citations
Items 101–149 of 149
Regulation of Calcium Metabolism
Russell, R. G. G. (1976) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456327601300155 · Cited by 8
Biochemical assessment of bone disease in multiple myeloma
Stepan, J. J., Neuwirtová, R., Pacovský, V., Formánková, J., & Šilinková-Málková, E. (1984) · Clinica Chimica Acta · doi:10.1016/s0009-8981(84)80001-7 · Cited by 8
Ultrastructural biology and pathology of the osteoclast
Marks, S. C., & Popoff, S. N. (1990) · Springer eBooks · doi:10.1007/978-1-4613-1487-5_13 · Cited by 8
Cabot, R. C., Scully, R. E., Mark, E. J., & McNeely, B. U. (1982) · New England Journal of Medicine · doi:10.1056/nejm198211113072008 · Cited by 8
Paraneoplastische endokrine Syndrome
Bauersfeld-Friemel, J., Komminoth, P., Heitz, P. U., & Klöppel, G. (2015) · Springer eBooks · doi:10.1007/978-3-642-04566-0_26 · Cited by 7
Review article : Pain in prostatic cancer
Ventafridda, V., Sbanotto, A., & Conno, F. D. (1990) · Palliative Medicine · doi:10.1177/026921639000400303 · Cited by 7
Metabolic Emergencies in Cancer Medicine
Ebie, N., Ryan, W. G., & Harris, J. E. (1986) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)30917-8 · Cited by 7
Bone Structure, Composition, and Mineralization
Boskey, A. L., & Posner, A. S. (1985) · Clinics in Podiatry · doi:10.1016/s0742-0668(23)00071-7 · Cited by 6
Biological Properties of Salmon Calcitonin IV
Schecroun, N., Pidoux, E., Horne, W. C., Hernandez‐Lagunas, L., Baron, R., & Cressent, M. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.8.1425 · Cited by 6
Interactions of Hormones, Ions, and Drugs in the Regulation of Osteoclastic Bone Resorption
Raisz, L. G., & Lorenzo, J. A. (1980) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-9167-2_61 · Cited by 6
Self-citationA Review of Therapeutic Trials in Multiple Myeloma and Perspectives for Future Trials
Vrana, M., & Bunn, P. A. (1980) · Elsevier eBooks · doi:10.1016/b978-0-444-00377-5.50018-2 · Cited by 5
Hypercalc�mie bei malignen Erkrankungen
Heidbreder, E., Schafferhans, K., & Heidland, A. (1983) · Journal of Molecular Medicine · doi:10.1007/bf01496721 · Cited by 5
Activation of serum complement inhibits collagen synthesis in fetal rat bone in organ culture
Kream, B. E., Raisz, L. G., & Sandberg, A. L. (1982) · Calcified Tissue International · doi:10.1007/bf02411270 · Cited by 5
Self-citationInduction of bone resorbing activity by normal and rheumatoid arthritis T cells
Flescher, E., Garrett, I., Mundy, G. R., & Talal, N. (1990) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(90)90142-d · Cited by 5
Self-citationOsteoclast-Mediated Cell Therapy as an Attempt to Treat Elastin Specific Vascular Calcification
Simpson, C. L., Mosier, J. A., & Vyavahare, N. R. (2021) · Molecules · doi:10.3390/molecules26123643 · Cited by 4
The idiopathic hypercalciuria reviewed. Metabolic abnormality or disease?
Nieto, V. M. G., Yanes, M. I. L., Tejera-Carreño, P., Pérez-Suárez, G., & Mesa, T. M. (2019) · Nefrología (English Edition) · doi:10.1016/j.nefroe.2019.12.005 · Cited by 4
Lymphoblastic leukemia with osteopenia and vertebral compression fractures
Leheup, B., Membre, H., Gérard, H., & Olive, D. (1985) · The Journal of Pediatrics · doi:10.1016/s0022-3476(85)80380-2 · Cited by 4
Metastatic pancreatic islet cell carcinoma with peptic ulcer disease and hypercalcemia
(1977) · The American Journal of Medicine · doi:10.1016/0002-9343(77)90126-7 · Cited by 4
Interactions of tumor necrosis factor with local and systemic factors in fetal rat limb bones
Shankar, G., & Stern, P. H. (1992) · Calcified Tissue International · doi:10.1007/bf00316885 · Cited by 3
Humoral hypercalcaemia in a patient with renal‐cell carcinoma
Powell, D., McPartlin, J. M., & Skrabanek, P. (1978) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1978.tb00876.x · Cited by 3
Hanzawa, K. (1986) · Japanese Journal of Oral Biology · doi:10.2330/joralbiosci1965.28.472 · Cited by 3
Cabot, R. C., Scully, R. E., Mark, E. J., McNeely, B. U., Kaufman, S. D., & Black-Schaffer, S. (1982) · New England Journal of Medicine · doi:10.1056/nejm198207013070108 · Cited by 3
Biologic Activity of Ectopic Parathyroid Hormone
Metz, S. A. (1977) · New England Journal of Medicine · doi:10.1056/nejm197701132960220 · Cited by 3
Local and Systemic Factors in the Pathogenesis of Osteoporosis
Raisz, L. G. (2001) · Elsevier eBooks · doi:10.1016/b978-012470862-4/50037-4 · Cited by 2
Self-citationParaneoplastische endokrine Syndrome
Heitz, P. U., & Staub, J. J. (1981) · Spezielle pathologische Anatomie · doi:10.1007/978-3-642-67691-8_6 · Cited by 2
Rohn, R. D., Werner, E. J., & Byrd, R. L. (1992) · Journal of Adolescent Health · doi:10.1016/1054-139x(92)90165-8 · Cited by 2
Einzig, A. I. (1987) · Springer eBooks · doi:10.1007/978-1-4899-0476-8_3 · Cited by 2
New bone resorption stimulation factor elaborated by a human osteosarcoma cell line.
Eilon, G., Trummel, C. L., Kream, B. E., & Viola, M. V. (1984) · PubMed · Cited by 2
Self-citationDisorders of Mineral Metabolism
Davie, M. W. J. (1984) · Elsevier eBooks · doi:10.1016/b978-0-433-30277-3.50010-5 · Cited by 2
Orthopedic Management of Osteoporosis: Effects of Nutrition and Exercise on the Skeleton
Lane, J. M., Healey, J. H., Vigorita, V. J., & Werntz, J. R. (1986) · Springer eBooks · doi:10.1007/978-3-642-70709-4_38 · Cited by 2
Ataş, A., Çakmak, A., Soran, M., Söker, M., & Varma, M. (2009) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0b013e3181acd925 · Cited by 1
Bone Biology: Bone Structure and Remodeling
Raisz, L. G. (2005) · Elsevier eBooks · doi:10.1016/b978-012183502-6/50003-1 · Cited by 2
Self-citationProstaglandins: promulgators of pain.
Nl, R. (1979) · PubMed Central · Cited by 1
Generation, Biology, and Assay of Efferent Lymphokines
Gemsa, D. (1988) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-73217-1_12 · Cited by 1
Studies on osteoclasts. The effects of OAF on osteoclasts isolated from the osteopetrotic patient.
Hanzawa, K., Sanjo, D., Shimizu, Y., & Kumagai, K. (1987) · Japanese Journal of Oral Biology · doi:10.2330/joralbiosci1965.29.530 · Cited by 1
Kaboth, U., & Hiddemann, W. (2008) · Springer eBooks · doi:10.1007/978-3-540-47648-1_4387 · Cited by 1
Symposium Knochenveränderungen bei malignen Tumoren
Ziegler, R., Mundy, G. R., Krempien, B., Lilienfeld-Toal, H. V., Freyschmidt, J., Schreml, W., & Minne, H. W. (1983) · Verhandlungen der Deutschen Gesellschaft für Innere Medizin · doi:10.1007/978-3-642-85456-9_25
Self-citationSaavedra, S. A. B., & Sandoval, J. C. T. (2013) · Cybertesis (National University of San Marcos)
Changes in bone and serum minerals after parathyroidectomy and their prevention by portacaval shunt
Al‐Jurf, A. S., & Smith, G. L. (1981) · Metabolism · doi:10.1016/0026-0495(81)90128-1
Bone Resorption Factors in Various Experimental Granuloma
Shirahata, Y., & Abramson, M. (1981) · Ear research Japan · doi:10.11289/otoljpn1981.12.146
Modulation of osteogenic differentiation in mesenchymal stromal cells
Gaynard, S., Hayes, J. S., & Murphy, M. J. (2016) · Wiley eBooks · doi:10.1002/9781118907474.ch12
Local and Systemic Factors in the Pathogenesis of Osteoporosis
Raisz, L. G. (2008) · Elsevier eBooks · doi:10.1016/b978-012370544-0.50040-9
Self-citationLavelle, C. L. B. (1988) · Elsevier eBooks · doi:10.1016/b978-0-7236-0818-9.50026-1
Vertebral Compression Fractures in the Course of Acute Lymphoblastic Leukemia in Children
Ochocka, M., Matysiak, M. J., ARMATA, J., Dobaczewski, G., Gawrońska, G., Michaleswska, D., Sońta-Jakimczyk, D., & Ŝladkowska, G. (1994) · Hämatologie und Bluttransfusion · doi:10.1007/978-3-642-78350-0_68
Ludwig, H. (1982) · Springer eBooks · doi:10.1007/978-3-642-68768-6_13
Heuck, F. (1983) · Handbuch der medizinischen Radiologie · doi:10.1007/978-3-642-81763-2_7
Rueger, J. M. (1992) · Springer eBooks · doi:10.1007/978-3-642-76585-8_10
Hematology-Oncology: An Annotated Bibliography of Recent Literature
HEMATOLOGY-ONCOLOGY COMMITTEE (1976) · Annals of Internal Medicine · doi:10.7326/0003-4819-84-6-758
Kidney and Bone: Physiological and Pathophysiological Relationships
Brown, E. M. (1991) · Comprehensive physiology · doi:10.1002/j.2040-4603.1991.tb01596.x
Metadata
- Authors
- Raisz, L. G., Luben, R. A., Mundy, G. R., Dietrich, J. W., Horton, J. E., & Trummel, C. L.
- Affiliations
- National Institutes of Health (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1975-08-01
- Volume
- 56
- Issue
- 2
- Pages
- 408-413
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC436600
- OpenAlex
- W2101357889
- Cited by
- 152
- References
- 14
- Citations by year
- 2021: 1 · 2019: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2013: 1
- FWCI
- 4.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
- Keywords
- osteoclast activating factor, bone resorption, bone metabolism, parathyroid hormone, calcitonin, cortisol, collagen synthesis, calcium release, leukocytes, phytohemagglutinin, prostaglandin E2, dose-response relationship, calvaria
- MeSH terms
- Animals, Bone and Bones, Bone Resorption, Calcitonin, Calcium, Calcium Radioisotopes, Collagen, Dose-Response Relationship, Drug, Female, Fetus, Humans, Indomethacin, Leukocytes, Organ Culture Techniques, Parathyroid Hormone, Phosphates, Pregnancy, Prostaglandins E, Time Factors, Rats
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