The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Effect of osteoclast activating factor from human leukocytes on bone metabolism.
Open accessAbstract
The effects of osteoclast activating factor (OAF) released by normal human peripheral blood leukocytes cultured with phytohemagglutinin have been examined in organ culture. Like parathyroid hormone (PTH), OAF causes a rapid increased in the release of previously incorporated 45Ca from fetal rat bone after brief or continuous exposure; the bones also lose stable calcium and collagen content. The resorption response to OAF also resembles that of PTH in having a steep dose response curve and being only transiently inhibited by calcitonin and partially inhibited by increasing medium phosphate concentration. OAF-stimulated resorption was inhibited more effectively by cortisol than was PTH stimulation. The response to maximally effective doses of OAF was not enhanced by PTH or prostaglandin E2, but submaximal doses gave additive effects. Both OAF and PTH inhibit collagen synthesis in fetal rat calvaria at the concentrations that stimulate bone resorption.
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“locally produced cytokines such as IL-1 and prostaglandins such as prostaglandin E 2 (PGE 2 ) can affect bone”
From Pathogenesis of osteoporosis: concepts, conflicts, and prospects (2005) · cites this paper as [82]
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Citations
Cites
Peterkofsky, B., & Diegelmann, R. F. (1971) · Biochemistry · doi:10.1021/bi00782a009 · Cited by 1,389
Prostaglandins: Stimulation of Bone Resorption in Tissue Culture
KLEIN, D. C., & RAISZ, L. G. (1970) · Endocrinology · doi:10.1210/endo-86-6-1436 · Cited by 969
Self-citationEvidence for the Secretion of an Osteoclast Stimulating Factor in Myeloma
Mundy, G. R., Raisz, L. G., Cooper, R. A., Schechter, G. P., & Salmon, S. E. (1974) · New England Journal of Medicine · doi:10.1056/nejm197411142912001 · Cited by 670
Self-citationBone resorbing activity in supernatant fluid from cultured human peripheral blood leukocytes
Horton, J. E., Raisz, L. G., Simmons, H. A., Oppenheim, J. J., & Mergenhagen, S. E. (1972) · Science · doi:10.1126/science.177.4051.793 · Cited by 565
Self-citationRaisz, L. G. (1969) · Endocrinology · doi:10.1210/endo-85-3-446 · Cited by 411
Self-citationBone-Resorbing Activity in Supernatants from Lymphoid Cell Lines
Mundy, G. R., Luben, R. A., Raisz, L. G., Oppenheim, J. J., & Buell, D. N. (1974) · New England Journal of Medicine · doi:10.1056/nejm197404182901601 · Cited by 293
Self-citationGrowth of embryonic avian and mammalian tibiae on a relatively simple chemically defined medium
Biggers, J. D., Gwatkin, R. B. L., & Heyner, S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90305-6 · Cited by 246
Inhibition of bone collagen synthesis by prostaglandin E2 in organ culture
Raisz, L. G., & Koolemans‐Beynen, A. (1974) · Prostaglandins · doi:10.1016/0090-6980(74)90113-0 · Cited by 176
Self-citationComplement-Dependent Stimulation of Prostaglandin Synthesis and Bone Resorption
Raisz, L. G., Sandberg, A. L., Goodson, J. M., Simmons, H. A., & Mergenhagen, S. E. (1974) · Science · doi:10.1126/science.185.4153.789 · Cited by 172
Self-citationWener, J. A., Gorton, S., & Raisz, L. G. (1972) · Endocrinology · doi:10.1210/endo-90-3-752 · Cited by 152
Self-citationTHE EFFECT OF PARATHYROID EXTRACT ON CELLULAR ACTIVITY AND PLASMA CALCIUM LEVELS IN VIVO
Bingham, P. J., Brazell, I. A., & Owen, M. E. (1969) · Journal of Endocrinology · doi:10.1677/joe.0.0450387 · Cited by 125
Macrophage-Lymphocyte Synergy in the Production of Osteoclast Activating Factor
Horton, J. E., Oppenheim, J. J., Mergenhagen, S. E., & Raisz, L. G. (1974) · The Journal of Immunology · doi:10.4049/jimmunol.113.4.1278 · Cited by 120
Self-citationLuben, R. A., Mundy, G. R., Trummel, C. L., & Raisz, L. G. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107696 · Cited by 87
Self-citationCheng, P.-T. H. (1969) · Journal of Investigative Dermatology · doi:10.1038/jid.1969.116 · Cited by 27
Cited by
Sorted by citations
Pathogenesis of osteoporosis: concepts, conflicts, and prospects
Raisz, L. G. (2005) · Journal of Clinical Investigation · doi:10.1172/jci27071 · Cited by 1,779
Self-citationBertolini, D. R., Nedwin, G. E., Bringman, T. S., Smith, D. D., & Mundy, G. R. (1986) · Nature · doi:10.1038/319516a0 · Cited by 1,425
Self-citationRole of osteoblasts in hormonal control of bone resorption—A hypothesis
Rodan, G. A., & Martin, T. J. (1981) · Calcified Tissue International · doi:10.1007/bf02409454 · Cited by 982
Hauschka, P. V., Mavrakos, A. E., Iafrati, M. D., Doleman, S. E., & Klagsbrun, M. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67143-1 · Cited by 862
Local and Systemic Factors in the Pathogenesis of Osteoporosis
Epstein, F. H., & Raisz, L. G. (1988) · New England Journal of Medicine · doi:10.1056/nejm198803313181305 · Cited by 490
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Metadata
- Authors
- Raisz, L. G., Luben, R. A., Mundy, G. R., Dietrich, J. W., Horton, J. E., & Trummel, C. L.
- Affiliations
- National Institutes of Health (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1975-08-01
- Volume
- 56
- Issue
- 2
- Pages
- 408-413
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC436600
- OpenAlex
- W2101357889
- Cited by
- 152
- References
- 14
- Citations by year
- 2021: 1 · 2019: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2013: 1
- FWCI
- 4.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
- Keywords
- osteoclast activating factor, bone resorption, bone metabolism, parathyroid hormone, calcitonin, cortisol, collagen synthesis, calcium release, leukocytes, phytohemagglutinin, prostaglandin E2, dose-response relationship, calvaria
- MeSH terms
- Animals, Bone and Bones, Bone Resorption, Calcitonin, Calcium, Calcium Radioisotopes, Collagen, Dose-Response Relationship, Drug, Female, Fetus, Humans, Indomethacin, Leukocytes, Organ Culture Techniques, Parathyroid Hormone, Phosphates, Pregnancy, Prostaglandins E, Time Factors, Rats
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