The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
The origin of the chemiluminescence of phagocytosing granulocytes.
Open accessAbstract
Granulocytes engaged in the phagocytosis of opsonized zymosan emit light by a process that is inhibited by superoxide dismutase and catalase. In the present report is is shown that light emission is the result of reactions between certain unspecified constituents of the ingested particles and some or all of the oxidizing agents (H2O2, O2),and possibly the hydroxyl radical and singlet oxygen) produced by the activated cells. This conclusion is based on a study of light emission by both activated cells ans artificial O2 generating system containing xanthine oxidase and purine. With these two systems light production required the presence of both zymosan and oxidizing agent, suggesting that the oxidation of particle components is necessary for luminescence to occur. The characteristics of the emission spectrum as well as the finding that granulocytes activated by a nonparticulate agent (F-) fail to liminesce show that light emission by the relaxation of singlet oxygen to the ground state does not contribute in a major way to the chemiluminescence of phagocytosing granulocytes; whether singlet oxygen contributes to chemiluminescence in other ways cannot be decided from the data available. Inasmuch as the oxidation of constituents of ingested particles is an important bacterial killing mechanism in the granulocyte, chemiluminescence may be viewed as a manifestation of the microbicidal activity of the cell.
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Cites
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Self-citationThe catalytic decomposition of hydrogen peroxide by iron salts
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Cited by
Oxygen metabolism and the toxic properties of phagocytes
KLEBANOFF, S. J. (1980) · Annals of Internal Medicine · doi:10.7326/0003-4819-93-3-480 · Cited by 868
Singlet Molecular Oxygen Reactions with Nucleic Acids, Lipids, and Proteins
Di Mascio, P., Martinez, G. R., Miyamoto, S., Ronsein, G. E., Medeiros, M. H. G., & Cadet, J. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00554 · Cited by 659
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Role of reactive oxygen metabolites in experimental glomerular disease
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Subcellular localization of the superoxide-forming enzyme in human neutrophils.
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Metadata
- Authors
- Cheson, B. D., Christensen, R. L., Sperling, R., Kohler, B. E., & Babior, B. M.
- Venue
- Journal of Clinical Investigation
- Published
- 1976-10-01
- Volume
- 58
- Issue
- 4
- Pages
- 789-796
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2048659050
- Cited by
- 277
- References
- 34
- FWCI
- 8.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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