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Stimulation of human eosinophil and neutrophil polymorphonuclear leukocyte chemotaxis and random migration by 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid.
Open accessAbstract
A C T A htuman platelet lipoxygenase-gen- erated prodtuct of arachidonic acid, identified by thin- layer chromiiatographic and mass spectrometric proper- ties as 12-L-hydroxy-5,8, 10,14-eicosatetraenoic acid (HETE), wvas selectively chemotactic in vitro for human polymnorplhontuclear leuikocytes (PMN), as compared to moniontuclear leukocytes, with a preference for eosinophils.Preincubation of PMN with partially- purified HETE at peak chemotactic concentrations of 8-24 /,g/ml redtuced their random and chemotactic migration and stimulated the activity of their hexose monophosphate shunt; minimally chemotactic concen- trations of 0.03-1 ,ug/ml enhanced PMN random migration without influiencing other functions.HETE may thtus be capable of preferentially attracting eosino- phils to foci of tisstue reaction associated with platelet activation.'Abbreviationis tised in this paper: HBSS-ovalbumin, Hanks' balanced salt solution made 0.4% in ovalbumin; HETE, 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid; HMPS, hexose monophosphate shunt; hpf, high power field; PMN, polymorphonuclear leukocyte(s).
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Citations
Cited by
Free radicals, oxidative stress, and antioxidants in human health and disease
Aruoma, O. I. (1998) · Journal of the American Oil Chemists' Society · doi:10.1007/s11746-998-0032-9 · Cited by 1,682
Arachidonic acid metabolism in polymorphonuclear leukocytes: Effects of ionophore A23187
Borgeat, P., & Samuelsson, B. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.5.2148 · Cited by 803
Platelet factor 4 is chemotactic for neutrophils and monocytes.
Deuel, T. F., Senior, R. M., Chang, D., Griffin, G. L., Heinrikson, R. L., & Kaiser, E. T. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.7.4584 · Cited by 431
Hydroxyeicosatetraenoic acids (HETEs)
Spector, A. A., Gordon, J. A., & Moore, S. A. (1988) · Progress in Lipid Research · doi:10.1016/0163-7827(88)90009-4 · Cited by 302
Mediators of immediate hypersensitivity
Wasserman, S. I. (1983) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(83)90512-2 · Cited by 288
Metadata
- Authors
- Goetzl, Woods, J. M., & Gorman, R. R.
- Venue
- Journal of Clinical Investigation
- Published
- 1977-01-01
- Volume
- 59
- Issue
- 1
- Pages
- 179-183
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2069348092
- Cited by
- 355
- References
- 0
- FWCI
- 17.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Goetzl, Woods, J. M., & Gorman, R. R. (1977). Stimulation of human eosinophil and neutrophil polymorphonuclear leukocyte chemotaxis and random migration by 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid. Journal of Clinical Investigation. https://doi.org/10.1172/jci108617
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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