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Cited by 431

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Platelet factor 4 is chemotactic for neutrophils and monocytes.

Open access
Deuel, T F, Senior, R M, Chang, D, Griffin, G L, Heinrikson, R L, Kaiser, E T·1981·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.78.7.4584
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Abstract

Platelet factor 4 is shown to be a chemotactic protein for human polymorphonuclear leukocytes and monocytes at concentrations found in human serum and reached locally in injured tissue. The maximum chemotactic response to platelet factor 4 nearly equals that achieved with saturating concentrations of the chemotactic activity derived from the fifth component of human complement, C5. Cells desensitized to C5 chemotactic activity retain chemotactic responsiveness to platelet factor 4. Serum contains inhibitory capacity against the chemotactic activity associated with platelet factor 4. Our results suggest that the local release of platelet factor 4 may be an important stimulus attracting inflammatory cells to sites of blood vessel injury.

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Metadata

Authors
Deuel, T. F., Senior, R. M., Chang, D., Griffin, G. L., Heinrikson, R. L., & Kaiser, E. T.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1981-07
Volume
78
Issue
7
Pages
4584-4587
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.78.7.4584
OpenAlex
W2012285989
Cited by
431
References
20
FWCI
8.04
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Platelet factor 4 is chemotactic for neutrophils and monocytes. https://app.cochat.ai/papers/10.1073/pnas.78.7.4584
The paper
Deuel, T. F., Senior, R. M., Chang, D., Griffin, G. L., Heinrikson, R. L., & Kaiser, E. T. (1981). Platelet factor 4 is chemotactic for neutrophils and monocytes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.78.7.4584

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.