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Superoxide generation by digitonin-stimulated guinea pig granulocytes. A basis for a continuous assay for monitoring superoxide production and for the study of the activation of the generating system.
Open accessAbstract
Stimulation of guinea pig granolocytes by digitonin results in superoxide (O-2) generation. A continuous assay shows that there is a lag between the addition of digitonin and the onset of O-2 production. The rate of activation of the O-2 generating system is dependent upon the concentration of digitonin and the temperature. The final linear rate of O-2 production is affected by the concentration of digitonin, temperature, pH, and the presence of exogenous reduced pyridine nucleotides. Thus, factors which alter either the activation process or the activity of the O-2 generating system can affect O-2 production by stimulated granolocytes.
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Citations
Cites
Pyridine nucleotide-dependent superoxide production by a cell-free system from human granulocytes.
Babior, B. M., Curnutte, J. T., & Kipnes, B. S. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108150 · Cited by 112
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Jurga, A. M., Paleczna, M., & Kuter, K. Z. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00198 · Cited by 1,000
RvE1 protects from local inflammation and osteoclastmediated bone destruction in periodontitis
Hasturk, H., Kantarci, A., Ohira, T., Arita, M., Ebrahimi, N., Chiang, N., Petasis, N. A., Levy, B. D., Serhan, C. N., & Van Dyke, T. E. (2006) · The FASEB Journal · doi:10.1096/fj.05-4724fje · Cited by 435
Clark, R. A., Leidal, K. G., Pearson, D. W., & Nauseef, W. M. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61312-2 · Cited by 271
Korchak, H. M., Vienne, K., Rutherford, L. E., Wilkenfeld, C., Finkelstein, M. C., & Weissmann, G. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43011-0 · Cited by 268
Metadata
- Authors
- Cohen, H. J., & Chovaniec, M. E.
- Venue
- Journal of Clinical Investigation
- Published
- 1978-04-01
- Volume
- 61
- Issue
- 4
- Pages
- 1081-1087
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2020704694
- Cited by
- 420
- References
- 1
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cohen, H. J., & Chovaniec, M. E. (1978). Superoxide generation by digitonin-stimulated guinea pig granulocytes. A basis for a continuous assay for monitoring superoxide production and for the study of the activation of the generating system. Journal of Clinical Investigation. https://doi.org/10.1172/jci109007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.