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Cited by 268

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Stimulus response coupling in the human neutrophil. II. Temporal analysis of changes in cytosolic calcium and calcium efflux.

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Korchak, H M, Vienne, K, Rutherford, L E, Wilkenfeld, C, Finkelstein, M C, Weissmann, G·1984·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(17)43011-0
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Abstract

The role of changes in cytosolic free calcium (Ca) in the activation sequence of the human neutrophil has been monitored by means of the fluorescent probe Quin2. "Complete" secretagogues such as the chemotactic peptide f-Met-Leu-Phe and aggregated IgG, as well as the "incomplete" secretagogue concanavalin A, elicited prompt rises in cytosolic Ca. The rise in cytosolic Ca was in all cases one of the earliest measurable events, consistent with the hypothesis that increments in cytosolic free Ca serve as a signal to activate subsequent physiological responses. The source of cytosolic Ca is principally intracellular, since removal of extracellular Ca had little effect on the rise in cytosolic Ca. Although increments in cytosolic Ca may be essential for neutrophil activation, they are evidently not sufficient; chemotactic levels of f-Met-Leu-Phe elicited optimal increments in cytosolic Ca without triggering degranulation, O-2 generation, and aggregation. Some other factor, associated with high levels of receptor occupancy, must be required for secretion. The tumor promoter phorbol myristate acetate was an exceptional stimulus, since it elicited degranulation, aggregation, and O-2 generation without triggering a rise in cytosolic Ca. Finally, an efflux of Ca is initiated which serves to maintain low intracellular levels of Ca.

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Metadata

Authors
Korchak, H. M., Vienne, K., Rutherford, L. E., Wilkenfeld, C., Finkelstein, M. C., & Weissmann, G.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1984-04
Volume
259
Issue
7
Pages
4076-4082
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(17)43011-0
OpenAlex
W1606716377
Cited by
268
References
20
FWCI
11.73
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Stimulus response coupling in the human neutrophil. II. Temporal analysis of changes in cytosolic calcium and calcium efflux. https://app.cochat.ai/papers/10.1016/s0021-9258(17)43011-0
The paper
Korchak, H. M., Vienne, K., Rutherford, L. E., Wilkenfeld, C., Finkelstein, M. C., & Weissmann, G. (1984). Stimulus response coupling in the human neutrophil. II. Temporal analysis of changes in cytosolic calcium and calcium efflux. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(17)43011-0

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.