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Insulin Binding to Monocytes and Insulin Action in Human Obesity, Starvation, and Refeeding
Open accessAbstract
Insulin binding to monocytes and insulin action in vivo was examined in 14 obese subjects during the postabsorptive state and after starvation and refeeding. Tissue sensitivity to insulin was evaluated with the euglycemic insulin clamp technique. The plasma insulin concentration is acutely raised and maintained 100 muU/ml above the fasting level, and plasma glucose is held constant by a variable glucose infusion. The amount of glucose infused is a measure of tissue sensitivity to insulin and averaged 285+/-15 mg/m(2) per min in controls compared to 136+/-13 mg/m(2) per min in obese subjects (P <0.001). (125)I-Insulin binding to monocytes averaged 8.3+/-0.4% in controls vs. 4.6+/-0.5% in obese subjects (P < 0.001). Insulin binding and insulin action were highly correlated in both control (r = 0.86, P < 0.001) and obese (r = 0.94, P < 0.001) groups. Studies employing tritiated glucose to measure glucose production indicated hepatic as well as extrahepatic resistance to insulin in obesity. After 3 and 14 days of starvation, insulin sensitivity in obese subjects decreased to 69+/-4 and 71+/-7 mg/m(2) per min, respectively, whereas (125)I-insulin binding increased to 8.8+/-0.7 and 9.0+/-0.4%. In contrast to the basal state, there was no correlation between insulin binding and insulin action. After refeeding, tissue sensitivity increased to 168+/-14 mg/m(2) per min (P < 0.001) whereas insulin binding fell to 5.0+/-0.3%. We conclude that (a) in the postabsorptive state insulin binding to monocytes provides an index of in vivo insulin action in nonobese and obese subjects and, (b) during starvation and refeeding, insulin binding and insulin action changes in opposite directions suggesting that postreceptor events determine in vivo insulin sensitivity.
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“Thus, our results are consistent with the diminished S of obese subjects elucidated by both qualitative (26) and quantitative techniques (25).”
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“Using the gold standard euglycemic hyperinsulinemic clamp technique to quantify insulin-stimulated glucose uptake, they demonstrated that both lean and obese T2DM subjects have marked decrease (>50%) in whole body glucose disposal during the insulin clamp.”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [28]
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“Both acute (4 hours) and chronic (4 days) physiologic elevation of plasma FFA concentration in insulin sensitive individuals impairs insulin signaling and causes insulin resistance in skeletal muscle [28, 62–68].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [28]
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Cites
THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS
Scatchard, G. (1949) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1949.tb27297.x · Cited by 19,724
Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity
Hunter, W. M., & Greenwood, F. C. (1962) · Nature · doi:10.1038/194495a0 · Cited by 6,902
Separation of leukocytes from blood and bone marrow
Bøyum, A. (1968) · Scandinavian Journal of Clinical and Laboratory Investigation · Cited by 2,696
The Glomerular Permeability Determined by Dextran Clearance Using Sephadex Gel Filtration
Mogensen, C. E. (1968) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365516809076979 · Cited by 2,654
INFLUENCES OF GLUCOSE LOADING AND OF INJECTED INSULIN ON HEPATIC GLUCOSE OUTPUT*
Steele, R. D. (1959) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1959.tb44923.x · Cited by 1,680
Gavin, J. R., Roth, J., Neville, D. M., MEYTS, P. D., & Buell, D. N. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.1.84 · Cited by 1,040
Hormone-fuel interrelationships during fasting.
Cahill, G. F., Herrera, M. G., Morgan, A. P., Soeldner, J. S., Steinke, J., Levy, P. L., Reichard, G. A., & Kipnis, D. M. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105481 · Cited by 1,036
LI, C. Y., Yam, L. T., & Lam, K. (1973) · Journal of Histochemistry & Cytochemistry · doi:10.1177/21.1.1 · Cited by 888
Effects of arterial versus venous sampling on analysis of glucose kinetics in man
McGuire, E. A., Helderman, J. H., Tobin, J. D., Andres, R., & Berman, M. D. (1976) · Journal of Applied Physiology · doi:10.1152/jappl.1976.41.4.565 · Cited by 704
Bagdade, J. D., Bierman, E. L., & Porte, D. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105646 · Cited by 672
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Research works printed but not linked: 3
- Marinetti, G. V., L. Schlatz, and K. Reilly. 1972. Insulin Action I. Academic Press, Inc., New York. 224.
- Radziuk, J., K. H. Norwich, and M. Vranic. 1974. Meas- urement and validation of nonsteady state turnover rates with application to the insulin and glucose systems. Fed. Proc. 33: 1855-1864.
- Snedecor, G. W., and W. G. Cochran. 1967. Statistical Methods. 6th edition. Iowa State University Press, Ames, Iowa. 593 pp.
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Items 201–251 of 251
Effect of Long‐Term Anticonvulsant Therapy on Glucose Metabolism in Humans
Lahtela, J. T. (1986) · Epilepsia · doi:10.1111/j.1528-1157.1986.tb03599.x · Cited by 7
Effects of marginally negative energy balance on insulin binding to erythrocytes of normal men
Garrel, D. R., Todd, K. S., & Calloway, D. H. (1984) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/39.5.716 · Cited by 7
DIABETES AND MINORITY POPULATIONS
Martinez, N. C. (1993) · Nursing Clinics of North America · doi:10.1016/s0029-6465(22)02838-9 · Cited by 13
Insulin Resistance and Ammo Acid Metabolism in Obesity
Caballero, B. H. (1987) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1987.tb36200.x · Cited by 6
Effects of fasting and refeeding on the activity of hepatic glucose‐6‐phosphatase in rats
Khan, A. W., Löw, H., & Efendić, S. (1985) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1985.tb00052.x · Cited by 6
Insulin receptors in diabetes and other conditions
Felig, P., & Soman, V. (1979) · The American Journal of Medicine · doi:10.1016/0002-9343(79)90628-4 · Cited by 6
Self-citationMANGNALL, D., Quayle, A., & Clark, R. G. (1984) · International Journal of Bio-Medical Computing · doi:10.1016/0020-7101(84)90039-4 · Cited by 5
Does fasting interval affect the glucose challenge test?
Berkus, M. D., Stern, M. P., Mitchell, B. D., Newton, E. R., & Langer, O. (1990) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(90)90755-v · Cited by 5
DeFronzo, R. A. (2003) · The British Journal of Diabetes · doi:10.1177/1474651403003001s0601 · Cited by 5
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Dooner, J., Burget, D. W., & Cleator, I. G. M. (1984) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607184008006660 · Cited by 5
A new test of peripheral insulin sensitivity using artificial beta cell
Valenta, L. J., Elias, A. N., Grossman, M. K., Tanner, S. M., & Friis, R. (1982) · Life Sciences · doi:10.1016/0024-3205(82)90601-4 · Cited by 5
Increased affinity of insulin receptor on hepatocytes from streptozotocin-induced diabetic rats.
Okamoto, M., Kuzuya, H., & Imura, H. (1984) · Endocrinologia Japonica · doi:10.1507/endocrj1954.31.235 · Cited by 5
Effect of Estradiol and Progesterone on Metabolic Biomarkers in Healthy Bitches
Tvarijonaviciute, A., Carrillo‐Sanchez, J., & Cerón, J. M. C. (2012) · Reproduction in Domestic Animals · doi:10.1111/rda.12120 · Cited by 4
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Abe, T., & Toda, C. (2024) · Journal of Visualized Experiments · doi:10.3791/65581 · Cited by 4
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Magnusson, J. L., & Tranberg, K. ‐. (1987) · Clinical Nutrition · doi:10.1016/0261-5614(87)90025-2 · Cited by 4
The effect of malnutrition on insulin binding to rat erythrocytes
Payne-Robinson, H. M., & Brown, R. C. D. (1992) · British Journal Of Nutrition · doi:10.1079/bjn19920031 · Cited by 4
Desoyé, G., Schmon, B., Gmoser, G., Friedl, H., Urdl, W., & Weiss, P. (1992) · Clinica Chimica Acta · doi:10.1016/0009-8981(92)90150-o · Cited by 4
The Spectrum of Insulin Resistance
Skyler, J. S. (1979) · Diabetes Care · doi:10.2337/diacare.2.3.319 · Cited by 4
Pathophysiology of Type 2 Diabetes
Kesavadev, J., Jawad, F., Deeb, A., Coetzee, A., Ansari, M., Shrestha, D., Somasundaram, N. P., & Kalra, S. (2019) · Springer eBooks · doi:10.1007/978-3-030-11815-0_8 · Cited by 3
Bays, H. E., Mandarino, L. J., & DeFronzo, R. A. (2004) · Cited by 3
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Dickersin, K., & Hewitt, P. (1986) · BMJ · doi:10.1136/bmj.293.6553.1000 · Cited by 3
Yokono, K., Imamura, Y., Shii, K., Sakai, H., & Baba, S. (1982) · Endocrinologia Japonica · doi:10.1507/endocrj1954.29.299 · Cited by 3
Asayama, K., Amemiya, S., Kato, K., & Shimizu, M. (1982) · Endocrinologia Japonica · doi:10.1507/endocrj1954.29.575 · Cited by 3
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Abdul‐Ghani, M. A., DeFronzo, R. A., & Eldor, R. (2015) · Wiley eBooks · doi:10.1002/9781118387658.ch46 · Cited by 2
Self-citationSex Variation in Dietary Regulation of Insulin Receptors in Man
Misbin, R. I., & Pullkinen, A. (1980) · Journal of Nutrition · doi:10.1093/jn/110.10.2109 · Cited by 2
Insulin-Stimulated Glucose Uptake and Fasting Blood Glucose.
Okamoto, M., Okamoto, M., Nishimura, H., Kosaki, A., Kono, S., Inoue, G., MAEDA, I., KUBOTA, M., Hayashi, T., Kuzuya, H., et al. (1991) · Endocrinologia Japonica · doi:10.1507/endocrj1954.38.421 · Cited by 2
In vivo insulin action in adrenodemedullated rats after voluntary running
Okada, S., Oshida, Y., Iguchi, A., & Sato, Y. (2004) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2003.11.021 · Cited by 2
Nutritional Management of Diabetes
Reaven, G. M., Coulston, A. M., & Marcus, R. (1979) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)31651-0 · Cited by 2
TİMUR, B., Tuncer, S. F., Bodur, S., Tımur, H., Tokmak, A., Güçel, F., & Altay, M. M. (2018) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2018.04.031 · Cited by 1
The association of DNA methylation patterns in TCF7L2 and GIPR genes with Type 2 Diabetes
Canivell, S. (2014) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 1
Insulin receptors and insulin sensitivity in normo and hyperinsulinemic obese patients
Artenisio, A. C., Ragonese, F., Forte, F., Saitta, G., Perrone, G., Lettina, G., Campisi, R., & Consolò, F. (1985) · Journal of Endocrinological Investigation · doi:10.1007/bf03348483 · Cited by 1
Red Blood Cell Insulin Binding Studies in Reye's Syndrome Survivors and Families
Kang, E. S., Solomon, S. S., Gates, R. E., & Schaeffer, S. J. (1982) · Endocrine Research Communications · doi:10.1080/07435808209045758 · Cited by 1
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Lager, I., & Lönnroth, P. (1983) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1983.tb08550.x · Cited by 1
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Misbin, R. I., & Gold, L. (1979) · New England Journal of Medicine · doi:10.1056/nejm197903013000915 · Cited by 1
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Kotronen, A. (2008) · Työväentutkimus Vuosikirja
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Ogunwole, J. O., Knight, E. M., Adkins, J. S., & Pointer, R. H. (1986) · Nutrition Research · doi:10.1016/s0271-5317(86)80008-2
Nutrition and insulin dependent diabetes in the young: General approaches
Pinelli, L., Olivieri, A. O., Maffeis, C., & Gonfiantini, E. (1989) · The Indian Journal of Pediatrics · doi:10.1007/bf02776466
Nutritional management of diabetes mellitus: rationale, ethics and practicability.
Debry, G., Drouin, P., Gariot, P., Pointel, J. P., Louis, J., Gross, P., & Couet, C. (1986) · Journal of the American College of Nutrition · doi:10.1080/07315724.1986.10720109
The Effect of Hypothyroidism on Glucose Tolerance in Dogs
Hofer‐Inteeworn, N. (2008) · VTechWorks (Virginia Tech)
Milner, J. J. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/c8p3-s268
ApproachtoTherap y in Patients With Newly Diagnosed Type 2 Diabetes
DeFronzo, R. A., & Eldor, R. (2013)
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Bergman, R. N., Phillips, L. S., & Cobelli, C. (1981)
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Colagiuri, S., & Br, J. (2014)
インスリン受容体の親和性変化 温度変化時のKinetic Study
Maegawa, H., 正, 小., 修明, 渡., Takada, Y., & 繁田, 幸. (1984) · 糖尿病 · doi:10.11213/tonyobyo1958.27.1025
Hollingsworth, D. R., & Cousins, L. M. (1982) · Springer eBooks · doi:10.1007/978-1-4684-3992-2_5
絶食状態における骨格筋のインスリン作用に関する研究 (I) インスリン受容体及び糖取り込みへの影響
Maegawa, H. (1985) · 糖尿病 · doi:10.11213/tonyobyo1958.28.571
Myers, T. R., & Goldhamer, A. C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-43044-9.00037-6
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(2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1985.tb02410.x
Obesity and insulin resistance: pathophysiology guiding precision therapy
Basu, A., & Basu, R. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91707-0.00008-5
Medical Indications for Weight Reduction
Lucas, C. P. (1984) · Springer eBooks · doi:10.1007/978-94-011-6716-1_3
Metabolic responses to 48 h fasting and refeeding in adults with and without obesity
Sandilands, R. E., Neudorf, H., Ursel, S., Shaba, H., Barg, D., Vaz, E. M., Schimweg, P., Islam, H., & Little, J. P. (2026) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2025-0447
Metadata
- Authors
- Defronzo, R. A., Soman, V., Sherwin, R. S., Hendler, R., & Felig, P.
- Affiliations
- Yale University (US)
- ORCID
- Defronzo, Ralph A.
- Venue
- Journal of Clinical Investigation
- Published
- 1978-07-01
- Volume
- 62
- Issue
- 1
- Pages
- 204-213
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC371755
- OpenAlex
- W1969572070
- Cited by
- 252
- References
- 41
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 3 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 3 · 2015: 2 · 2014: 4 · 2013: 3 · 2012: 5
- FWCI
- 33.28
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- National Institutes of Health (RR-00125)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- insulin binding, monocytes, insulin resistance, obesity, starvation, refeeding, postabsorptive state, insulin action, hepatic insulin resistance, hyperinsulinemic-euglycemic clamp, glucose production
- MeSH terms
- Adolescent, Adult, Eating, Female, Glucose, Humans, Insulin, Liver, Male, Middle Aged, Monocytes, Obesity, Starvation
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