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Promotion of human adipocyte precursor replication by 17beta-estradiol in culture
Open accessAbstract
The influence of 17beta-estradiol and 17alpha-estradiol on adult human omental adipocyte precursors grown in a propagating culture system was studied. Cells were grown in subculture in the presence or absence of hormone. 17beta-estradiol resulted in significant promotion of adipocyte precursor replication, as determined by cell counting and incorporation of radioactive thymidine into DNA. The hormone stimulated cell multiplication in the concentration range 0.5--500 ng/ml growth medium. The highest level tested was 500 ng/ml. The maximal effects were obtained at 50 ng/ml (P less than 0.001 by paired t test, 48 h after hormone addition). All 10 cell strains (five were derived from men and five from women) that were tested responded similarly to the hormone. 17beta-estradiol did not affect cell size. 17alpha-estradiol did not promote the replication of adipocyte precursors, nor did it influence cell size. Thus, 17beta-estradiol, which is the active isomer in known target tissues, stimulates the multiplication of human adipocyte precursors in culture.
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“E2 also increases preadipocyte proliferation, suggesting an adipogenic effect (167).”
From Metabolic impact of endogenously produced estrogens by adipose tissue in females and males across the lifespan (2025) · cites this paper as [167]
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Metadata
- Authors
- Roncari, D. A., & Van, R. L.
- Affiliations
- University of Toronto (CA)
- Venue
- Journal of Clinical Investigation
- Published
- 1978-09-01
- Volume
- 62
- Issue
- 3
- Pages
- 503-508
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC371792
- OpenAlex
- W2040874095
- Cited by
- 128
- References
- 18
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 5
- FWCI
- 4.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Atkinson Foundation
- Medical Research Council
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- estradiol, 17α-estradiol, adipocyte precursors, adipocyte proliferation, cell replication, omental adipose tissue, cell size, human adipocytes
- MeSH terms
- Adipose Tissue, Adult, Cell Differentiation, Cell Division, Cells, Cultured, DNA, Estradiol, Female, Humans, Male, Thymidine
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