Cited by 128Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesLipid metabolism and biosynthesis

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Promotion of human adipocyte precursor replication by 17beta-estradiol in culture

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Roncari, D A, Van, R L·1978·Journal of Clinical Investigation

DOI 10.1172/jci109153PMC PMC371792

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Abstract

The influence of 17beta-estradiol and 17alpha-estradiol on adult human omental adipocyte precursors grown in a propagating culture system was studied. Cells were grown in subculture in the presence or absence of hormone. 17beta-estradiol resulted in significant promotion of adipocyte precursor replication, as determined by cell counting and incorporation of radioactive thymidine into DNA. The hormone stimulated cell multiplication in the concentration range 0.5--500 ng/ml growth medium. The highest level tested was 500 ng/ml. The maximal effects were obtained at 50 ng/ml (P less than 0.001 by paired t test, 48 h after hormone addition). All 10 cell strains (five were derived from men and five from women) that were tested responded similarly to the hormone. 17beta-estradiol did not affect cell size. 17alpha-estradiol did not promote the replication of adipocyte precursors, nor did it influence cell size. Thus, 17beta-estradiol, which is the active isomer in known target tissues, stimulates the multiplication of human adipocyte precursors in culture.

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Chan, L., & O’Malley, B. W. (1976) · New England Journal of Medicine · doi:10.1056/nejm197606102942405 · Cited by 293
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INTERACTION OF ESTROGEN AND PROGESTERONE IN CHICK OVIDUCT DEVELOPMENT
Oka, T., & SCHIMKE, R. T. (1969) · The Journal of Cell Biology · doi:10.1083/jcb.43.1.123 · Cited by 253
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Munkres, K. D., & Richards, F. M. (1965) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(65)90391-7 · Cited by 237
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Synthesis of very low density lipoproteins in the cockerel. Effects of estrogen.
Chan, L., Jackson, R. L., O’Malley, B. W., & Means, A. R. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108481 · Cited by 164
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Luskey, K. L., Brown, M. S., & Goldstein, J. L. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)79909-6 · Cited by 132
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Self-citation
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Vasselli, J. R., Cleary, M. P., & Itallie, T. B. V. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1983.tb07142.x · Cited by 31
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Lau, D. C. W., Roncari, D. A. K., Yip, D. K., Kindler, S., & Nilsen, S. G. E. (1983) · FEBS Letters · doi:10.1016/0014-5793(83)80651-6 · Cited by 25
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Self-citation
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Björntorp, P. A., Faust, I. M., Miller, W. H., Karlsson, M., Sypniewska, G., & Dahlgren, K. (1985) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34250-4 · Cited by 19
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Bulfer, J. M., & Allen, C. E. (1979) · BioScience · doi:10.2307/1307668 · Cited by 17
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Cryer, A., & Van, R. L. (1982) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1982.tb00998.x · Cited by 17
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Balogun, K. A., & Cheema, S. K. (2015) · Lipids · doi:10.1007/s11745-015-4105-x · Cited by 15
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Oh, Y. S., Cho, S. B., Baek, K. H., & Choi, C. B. (2005) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2005.1589 · Cited by 15
β-Adrenergic desensitization by chronic insulin exposure in 3T3-L1 cultured adipocytes
Olansky, L., & Pohl, S. L. (1984) · Metabolism · doi:10.1016/0026-0495(84)90165-3 · Cited by 15
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Santos, E. D., Dieudonné, M., Leneveu, M.-C., Serazin-Leroy, V., Rincheval, V., Mignotte, B., Chouillard, E. K., de Mazancourt, P., Giudicelli, Y., & Pecquery, R. (2010) · Hormone and Metabolic Research · doi:10.1055/s-0030-1249639 · Cited by 13
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Authors: Roncari, D. A., & Van, R. L.
Affiliations: University of Toronto (CA)
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1978-09-01
Volume: 62
Issue: 3
Pages: 503-508
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci109153
PMC: PMC371792
OpenAlex: W2040874095
Cited by: 128
References: 18
Citations by year: 2025: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 5
FWCI: 4.52
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Atkinson Foundation
Medical Research Council
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: estradiol, 17α-estradiol, adipocyte precursors, adipocyte proliferation, cell replication, omental adipose tissue, cell size, human adipocytes
MeSH terms: Adipose Tissue, Adult, Cell Differentiation, Cell Division, Cells, Cultured, DNA, Estradiol, Female, Humans, Male, Thymidine

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Promotion of human adipocyte precursor replication by 17beta-estradiol in culture

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