Hepatic fuel metabolism during muscular work: role and regulation

Wasserman, D. H.; Cherrington, A. D.

doi:10.1152/ajpendo.1991.260.6.e811

Cited by 137Metabolism, Diabetes, and CancerMuscle metabolism and nutritionCardiovascular and exercise physiology

Hepatic fuel metabolism during muscular work: role and regulation

Wasserman, D. H., Cherrington, A. D.·1991·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.1991.260.6.e811

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Abstract

The increased fuel demands of the working muscle necessitate that metabolic processes within the liver be accelerated accordingly. The sum of changes in hepatic glycogenolysis and gluconeogenesis are closely coupled to the increase in glucose uptake by the working muscle, due to the actions of the pancreatic hormones. The exercise-induced rise in glucagon and fall in insulin interact to stimulate hepatic glycogenolysis, whereas the increase in gluconeogenesis is determined primarily by glucagon action. The increment in gluconeogenesis is caused by increases in hepatic gluconeogenic precursor delivery and fractional extraction as well as in the efficiency of intrahepatic conversion to glucose. Glucagon stimulates the latter two processes. Epinephrine may become important in the regulation of hepatic glucose production during prolonged or heavy exercise when its levels are particularly high. On the other hand, there is no evidence that hepatic innervation is essential for the rise in hepatic glucose production during exercise. Nonesterified fatty acid (NEFA) delivery to, uptake of, and oxidation by the liver are accelerated during prolonged exercise, resulting in an increase in ketogenesis. The rate of the first two of these processes is largely determined by factors that stimulate fat mobilization. The third step is regulated by both NEFA delivery to and glucagon-stimulated fat oxidation within the liver. The increase in hepatic fat oxidation produces energy that fuels glucone…

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Self-citation

Authors: Wasserman, D. H., & Cherrington, A. D.
ORCID: Wasserman, D. H.
Cherrington, A. D.
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 1991-06-01
Volume: 260
Issue: 6
Pages: E811-E824
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.1991.260.6.e811
OpenAlex: W1932762496
Cited by: 137
References: 82
Citations by year: 2026: 1 · 2024: 4 · 2023: 8 · 2022: 6 · 2021: 4 · 2020: 5 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 8 · 2015: 3 · 2014: 7 · 2013: 6 · 2012: 5
FWCI: 0.29
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords: hepatic glucose production, physical activity, hepatic glycogenolysis, gluconeogenesis, glucagon, insulin, epinephrine, free fatty acids, ketogenesis, amino acid metabolism, muscle glucose uptake, pancreatic hormones, hepatic innervation, lipid mobilization
MeSH terms: Animals, Energy Metabolism, Epinephrine, Physical Exertion, Glucagon, Homeostasis, Insulin, Liver, Models, Biological, Muscles

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Hepatic fuel metabolism during muscular work: role and regulation

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