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Reactivity of a monoclonal antibody with human ovarian carcinoma.
Open accessAbstract
A murine monoclonal antibody (OC125) has been developed that reacts with each of six epithelial ovarian carcinoma cell lines and with cryopreserved tumor tissue from 12 of 20 ovarian cancer patients. By contrast, the antibody does not bind to a variety of nonmalignant tissues, including adult and fetal ovary. OC125 reacts with only 1 of 14 cell lines derived from nonovarian neoplasms and has failed to react with cryostat sections from 12 nonovarian carcinomas.
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Metadata
- Authors
- Bast, R. C., Feeney, M., Lazarus, H., Nadler, L. M., Colvin, R. B., & Knapp, R. C.
- Venue
- Journal of Clinical Investigation
- Published
- 1981-11-01
- Volume
- 68
- Issue
- 5
- Pages
- 1331-1337
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2102719470
- Cited by
- 1,661
- References
- 0
- FWCI
- 12.50
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Reactivity of a monoclonal antibody with human ovarian carcinoma. https://app.cochat.ai/papers/10.1172/jci110380
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- Bast, R. C., Feeney, M., Lazarus, H., Nadler, L. M., Colvin, R. B., & Knapp, R. C. (1981). Reactivity of a monoclonal antibody with human ovarian carcinoma. Journal of Clinical Investigation. https://doi.org/10.1172/jci110380
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
