The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Spontaneous oxygen radical generation by sickle erythrocytes.
Open accessAbstract
Since the various membrane abnormalities of sickle erythrocytes might result from excessive accumulation of oxidant damage, we have measured the generation of superoxide, peroxide, and hydroxyl radical by normal and sickle erythrocytes using assays involving reduction of cytochrome c, aminotriazole inhibition of catalase, and methane evolution from dimethyl sulfoxide, respectively. Compared with normal erythrocytes, sickle erythrocytes spontaneously generate approximately twice as much superoxide, peroxide, and hydroxyl radical. One possible source of hydroxyl radical generation was identified as hemichrome, excessive amounts of which are bound to sickle erythrocyte membranes. Hemichrome did not generate hydroxyl radical when exposed to superoxide alone or peroxide alone. However, in the presence of both superoxide and peroxide, hemichrome greatly facilitated hydroxyl radical generation. Supporting this, normal erythrocyte membranes induced to acquire sickle hemichrome concomitantly acquired an enhanced ability to mediate hydroxyl radical generation. Finally, sickle erythrocyte membranes greatly enhanced superoxide/peroxide-driven hydroxyl radical generation as compared with normal erythrocyte membranes. These data suggest that an excessive accumulation of oxidant damage in sickle erythrocyte membranes might contribute to the accelerated membrane senescence of these cells. They further indicate that accumulation of oxidant damage could be a determinant of normal erythrocyte membrane senescence.
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Citations
Cites
The Generation of Superoxide Radical during the Autoxidation of Hemoglobin
Misra, H. P., & Fridovich, I. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)44679-6 · Cited by 1,174
Superoxide‐dependent production of hydroxyl radical catalyzed by iron—EDTA complex
McCord, J. M., & Day, E. D. (1978) · FEBS Letters · doi:10.1016/0014-5793(78)80116-1 · Cited by 868
In vivo inhibition of superoxide dismutase in mice by diethyldithiocarbamate.
Heikkila, R. E., Cabbat, F. S., & Cohen, G. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33675-x · Cited by 452
Abnormal Adherence of Sickle Erythrocytes to Cultured Vascular Endothelium
Hebbel, R. P., Yamada, O., Moldow, C. F., Jacob, H. S., White, J. G., & Eaton, J. W. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109646 · Cited by 423
Self-citationInside-Out Red Cell Membrane Vesicles: Preparation and Purification
Steck, T. L., Weinstein, R. S., Straus, J. H., & Wallach, D. F. H. (1970) · Science · doi:10.1126/science.168.3928.255 · Cited by 412
Defective Superoxide Production by Granulocytes from Patients with Chronic Granulomatous Disease
Curnutte, J. T., Whitten, D. M., & Babior, B. M. (1974) · New England Journal of Medicine · doi:10.1056/nejm197403142901104 · Cited by 371
Generation of Hydrogen Peroxide in Erythrocytes by Hemolytic Agents*
Cohen, G., & Hochstein, P. (1964) · Biochemistry · doi:10.1021/bi00895a006 · Cited by 350
Annotation: ACTIVATED OXYGEN AND HAEMOLYSIS
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Generation of Hydroxyl Radical by Enzymes, Chemicals, and Human Phagocytes In Vitro
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Self-citationAbnormalities in membrane phospholipid organization in sickled erythrocytes.
Lubin, B., Chiu, D., Bastacky, J., Roelofsen, B., & Van Deenen, L. L. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110200 · Cited by 259
Cited by
Oxygen toxicity, oxygen radicals, transition metals and disease
Halliwell, B., & Gutteridge, J. M. C. (1984) · Biochemical Journal · doi:10.1042/bj2190001 · Cited by 5,330
A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding
Perron, N. R., & Brumaghim, J. L. (2009) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-009-9043-x · Cited by 1,370
Zhang, D., Xu, C., Manwani, D., & Frenette, P. S. (2016) · Blood · doi:10.1182/blood-2015-09-618538 · Cited by 413
Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease
Aslan, M., Ryan, T. M., Adler, B., Townes, T. M., Parks, D. A., Thompson, J. A., Tousson, A., Gladwin, M. T., Patel, R. P., Tarpey, M. M., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221292098 · Cited by 391
Lipid peroxidation in erythrocytes
Clemens, M. R., & Waller, H. D. (1987) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(87)90068-5 · Cited by 318
Metadata
- Authors
- Hebbel, R. P., Eaton, J. W., Balasingam, M., & Steinberg, M. H.
- Venue
- Journal of Clinical Investigation
- Published
- 1982-12-01
- Volume
- 70
- Issue
- 6
- Pages
- 1253-1259
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2019449116
- Cited by
- 441
- References
- 20
- FWCI
- 9.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hebbel, R. P., Eaton, J. W., Balasingam, M., & Steinberg, M. H. (1982). Spontaneous oxygen radical generation by sickle erythrocytes. Journal of Clinical Investigation. https://doi.org/10.1172/jci110724
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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