Lipid peroxidation in erythrocytes

Clemens, Michael R.; Waller, Hans Dierck

doi:10.1016/0009-3084(87)90068-5

Cited by 318Antioxidant Activity and Oxidative StressRedox biology and oxidative stressErythrocyte Function and Pathophysiology

Lipid peroxidation in erythrocytes

Clemens, Michael R., Waller, Hans Dierck·1987·Chemistry and Physics of Lipids

DOI 10.1016/0009-3084(87)90068-5

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Abstract

Erythrocytes might be expected to be highly susceptible to peroxidation. Their membranes are rich in polyunsaturated fatty acids; they are continuously exposed to high concentrations of oxygen; and they contain a powerful transition metal catalyst. In fact, autoxidation is held in check in vivo by extremely efficient protective antioxidant mechanisms. These involve cellular enzymes such as superoxide dismutase and glutathione peroxidase, as well as vitamin E; but they mainly reflect effective structural compartmentalisation. This review surveys mechanisms which lead to red cell lipid autoxidation and the role of haemoglobin in these processes. The influence of haemoglobinopathies, of lipid composition and of abnormalities in antioxidant mechanisms induced by exogenous oxidant stress is also considered.

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Malfunction of antioxidant defense and/or conditions of increased oxidant production have severe consequences for RBCs on a subcellular level.
“Malfunction of antioxidant defense and/or conditions of increased oxidant production have severe consequences for RBCs on a subcellular level.”
From Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia (2017) · cites this paper as [37]

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Self-citation
The fatty acid composition of red cells deficient in glucose-6-phosphate dehydrogenase and their susceptibility to lipid peroxidation
Clemens, M., Einsele, H., & Waller, H. D. (1985) · Journal of Molecular Medicine · doi:10.1007/bf01733008 · Cited by 17 · see citing works
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Lipid abnormalities in plasma and red cell membranes of chronic alcoholics
Clemens, M., Schied, H. W., Daiß, W., et al. (1986) · Journal of Molecular Medicine · doi:10.1007/bf01713460 · Cited by 17 · see citing works
Self-citation
Alcohol consumption and hepatic fibrosis affect the fatty acid composition of red blood cells and their susceptibility to lipid peroxidation
Clemens, M., Einsele, H., & Remmer, H. (1987) · Archives of Toxicology · doi:10.1007/bf00296973 · Cited by 17 · see citing works
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Lipid Peroxidation in Human Erythrocytes in Tocopherol Deficiency
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[TOXIC HEMOLYTIC ANEMIAS].
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Zur Entstehung der medikamenteninduzierten Anämie bei Glutathionreduktase-Mangelträgern
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Hydrazine and sickle cells
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Aktivierung der Glutathionreductase roter Blutzellen mit Flavin-Adenin-Dinucleotid (FAD)
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Glutathionreductase menschlicher Blutzellen und ihre Aktivierbarkeit durch Flavin-Adenin-Dinucleotid (FAD)
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Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia
Kuhn, V., Diederich, L., Keller, T. C. S., Kramer, C. M., Lückstädt, W., Panknin, C., Suvorava, T., Isakson, B. E., Kelm, M., & Cortese-Krott, M. M. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6954 · Cited by 469 · see citing works
Protection and Recycling of α-Tocopherol in Human Erythrocytes by Intracellular Ascorbic Acid
May, J. M., Qu, Z.-C., & Mendiratta, S. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0473 · Cited by 316 · see citing works
Antioxidant response to oxidative stress induced by exhaustive exercise
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The Redox Activity of Hemoglobins: From Physiologic Functions to Pathologic Mechanisms
Reeder, B. J. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2974 · Cited by 189 · see citing works
Inborn defects in the antioxidant systems of human red blood cells
van Zwieten, R., Verhoeven, A. J., & Roos, D. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.11.022 · Cited by 179 · see citing works

Overexpression of Cellular Glutathione Peroxidase Does Not Affect Expression of Plasma Glutathione Peroxidase or Phospholipid Hydroperoxide Glutathione Peroxidase in Mice Offered Diets Adequate or Deficient in Selenium
Cheng, W., Ho, Y., Ross, D. A., Han, Y., Combs, G. F., & Lei, X. G. (1997) · Journal of Nutrition · doi:10.1093/jn/127.5.675 · Cited by 85 · see citing works
The Effect of Selenium and Vitamin E Supplement on the Serum Concentrations of Antioxidant and F2 Isoprostanes in Arabian Horses during the Training Season
Hassanpour, A., Moghaddam, G., & Mirzaie, H. (2011)
The effect of chronic ethanol ingestion on hepatic lipid peroxide, glutathione, glutathione peroxidase and glutathione transferase in rats
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The Effects of Hyperthyroidism on Lipid Peroxidation, Erythrocyte Glutathione and Glutathione Peroxidase
Ali, A. A., & Sultan, P. (2010) · Journal of Medical Biochemistry · doi:10.2478/v10011-010-0048-1 · Cited by 8 · see citing works
Glutathione and glutathione metabolizing enzymes in yeasts
Casalone, E., Ilio, C. D., Federici, G., et al. (1988) · Antonie van Leeuwenhoek · doi:10.1007/bf00393527 · Cited by 18 · see citing works

Authors: Clemens, M. R., & Waller, H. D.
Affiliations: University of Tübingen (DE)
Corresponding author: Clemens, Michael R.
Venue: Chemistry and Physics of Lipids
Publisher: Elsevier BV
Published: 1987-11
Volume: 45
Issue: 2-4
Pages: 251-268
ISSN: 0009-3084 (ISSN-L)
DOI: 10.1016/0009-3084(87)90068-5
OpenAlex: W2029684018
Cited by: 318
References: 115
Citations by year: 2026: 1 · 2025: 2 · 2024: 5 · 2023: 8 · 2022: 11 · 2021: 4 · 2020: 5 · 2019: 1 · 2018: 5 · 2017: 7 · 2016: 12 · 2015: 7 · 2014: 16 · 2013: 14 · 2012: 11
FWCI: 0.38
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Chemistry and Physics of Lipids (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Physiology › Erythrocyte Function and Pathophysiology
Keywords: lipid peroxidation, erythrocytes, autoxidation, polyunsaturated fatty acids, transition metal catalysis, antioxidant enzymes, superoxide dismutase, glutathione peroxidase, vitamin E, hemoglobin, hemoglobinopathies, lipid composition, oxidative stress
MeSH terms: Animals, Erythrocytes, Hemoglobins, Humans, Lipid Peroxides

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Lipid peroxidation in erythrocytes

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