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Human renal carcinoma cells produce hypercalcemia in the nude mouse and a novel protein recognized by parathyroid hormone receptors.
Open accessAbstract
When grown in nude mice, cultured renal carcinoma cells from a hypercalcemic patient produced marked hypercalcemia that was reversed by resection of tumor. Conditioned medium from this cell line contained a protein with activity in a renal adenylate cyclase bioassay for parathyroid hormone (PTH) which was blocked by the competitive PTH antagonist [8norleucyl, 18norleucyl, 34tyrosinyl]bPTH (3-34)amide. However, the biologically active protein was eluted from gel filtration columns as a larger molecular size component that PTH and was not recognized by any of four region-specific PTH antisera. The properties of this factor resemble those of the postulated PTH-like substance(s) in humoral hypercalcemia of malignancy.
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Cited by
A Parathyroid Hormone-Related Protein Implicated in Malignant Hypercalcemia: Cloning and Expression
Suva, L. J., Winslow, G. A., Wettenhall, R. E. H., Hammonds, R. G., Moseley, J. M., Diefenbach-Jagger, H., Rodda, C. P., Kemp, B. E., Rodriguez, H., Chen, E. Y., et al. (1987) · Science · doi:10.1126/science.3616618 · Cited by 1,293
Parathyroid hormone-related protein purified from a human lung cancer cell line.
Moseley, J. M., Kubota, M., Diefenbach-Jagger, H., Wettenhall, R. E., Kemp, B. E., Suva, L. J., Rodda, C. P., Ebeling, P. R., Hudson, P. J., & Zajac, J. D. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.14.5048 · Cited by 734
Mangin, M., Webb, A. C., Dreyer, B. E., Posillico, J. T., Ikeda, K., Weir, E. C., Stewart, A. F., Bander, N. H., Milstone, L., & Barton, D. E. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.2.597 · Cited by 428
Burtis, W. J., Wu, T., Bunch, C., Wysolmerski, J. J., Insogna, K. L., Weir, E. C., Broadus, A. E., & Stewart, A. F. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48217-8 · Cited by 372
Chorev, M., Roubini, E., McKee, R. L., Gibbons, S. W., Goldman, M. E., Caulfield, M. P., & Rosenblatt, M. (1991) · Biochemistry · doi:10.1021/bi00238a022 · Cited by 107
Metadata
- Authors
- Strewler, G. J., Williams, R. D., & Nissenson, R. A.
- Venue
- Journal of Clinical Investigation
- Published
- 1983-03-01
- Volume
- 71
- Issue
- 3
- Pages
- 769-774
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2099216574
- Cited by
- 173
- References
- 0
- FWCI
- 18.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Human renal carcinoma cells produce hypercalcemia in the nude mouse and a novel protein recognized by parathyroid hormone receptors. https://app.cochat.ai/papers/10.1172/jci110825
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- Strewler, G. J., Williams, R. D., & Nissenson, R. A. (1983). Human renal carcinoma cells produce hypercalcemia in the nude mouse and a novel protein recognized by parathyroid hormone receptors. Journal of Clinical Investigation. https://doi.org/10.1172/jci110825
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