CoChat
Sign Up
Cited by 618Receptor Mechanisms and SignalingCardiac Fibrosis and RemodelingCardiomyopathy and Myosin Studies

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha-1 adrenergic response

Open access
Simpson, P·1983·Journal of Clinical Investigation
DOI 10.1172/jci111023PMC PMC1129233
Open this paper in CoChat — free accountOpen PDF

Abstract

We have shown recently that norepinephrine stimulates muscle cell hypertrophy in primary cultures from the neonatal rat ventricle and that this stimulation is not blocked by the beta adrenergic antagonist propranolol. The present study was done to define the adrenergic specificity of the myocyte hypertrophic response to norepinephrine. 90% pure, single-cell cultures of nongrowing myocytes were maintained in serum-free medium 199 with transferin and insulin. Myocyte size was quantitated 48 h after addition of adrenergic agents, by measuring cell volume, cell surface area, and cell protein. L-norepinephrine increased myocyte size to a maximum 150% of control; half-maximum effect was obtained at a concentration of 0.2 microM. This increase in cell size was inhibited by the nonselective alpha adrenergic antagonist phentolamine and by the alpha 1 adrenergic antagonists prazosin and terazosin; it was not inhibited by propranolol or by the alpha 2 adrenergic antagonist yohimbine. The beta adrenergic agonist isoproterenol did not increase cell size. Thus, norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1172/jci111023

Cites

20 of 20 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 20 references

Research works printed but not linked: 1

  1. Kyncl, J. J., E. N. Bush, and S. A. Buckner. 1982. Alpha adrenergic blocking properties of terazosin. Fed. Proc. 41:1648.

Cited by

Sorted by citations

Items 301–400 of 618

Related

See all

Metadata

Authors
Simpson, P.
Affiliations
San Francisco VA Medical Center (US)
Corresponding author
Simpson, P
ORCID
Simpson, P
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1983-08-01
Volume
72
Issue
2
Pages
732-738
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci111023
PMC
PMC1129233
OpenAlex
W2110889457
Cited by
618
References
20
Citations by year
2026: 4 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 3 · 2013: 10 · 2012: 6
FWCI
3.65
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of California, San Francisco
  • National Heart, Lung, and Blood Institute (R01HL031113)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
Keywords
norepinephrine, cardiac hypertrophy, alpha1-adrenoceptors, alpha-blockers, phentolamine, prazosin, terazosin, yohimbine, isoproterenol, propranolol
MeSH terms
Adrenergic alpha-Antagonists, Animals, Cardiomegaly, Isoproterenol, Myocardium, Norepinephrine, Phentolamine, Prazosin, Propranolol, Receptors, Adrenergic, Receptors, Adrenergic, alpha, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review