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Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha-1 adrenergic response
Open accessAbstract
We have shown recently that norepinephrine stimulates muscle cell hypertrophy in primary cultures from the neonatal rat ventricle and that this stimulation is not blocked by the beta adrenergic antagonist propranolol. The present study was done to define the adrenergic specificity of the myocyte hypertrophic response to norepinephrine. 90% pure, single-cell cultures of nongrowing myocytes were maintained in serum-free medium 199 with transferin and insulin. Myocyte size was quantitated 48 h after addition of adrenergic agents, by measuring cell volume, cell surface area, and cell protein. L-norepinephrine increased myocyte size to a maximum 150% of control; half-maximum effect was obtained at a concentration of 0.2 microM. This increase in cell size was inhibited by the nonselective alpha adrenergic antagonist phentolamine and by the alpha 1 adrenergic antagonists prazosin and terazosin; it was not inhibited by propranolol or by the alpha 2 adrenergic antagonist yohimbine. The beta adrenergic agonist isoproterenol did not increase cell size. Thus, norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response.
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“In support of this, catecholamines have been shown experimentally to have trophic properties on cardiac myocytes (35)and in the intact animal heart (36).”
From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [35]
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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Feinleib, M., & Zar, J. H. (1975) · Journal of the American Statistical Association · doi:10.2307/2285423 · Cited by 12,671
Zar, J. H. (1996) · Cited by 7,837
Presynaptic regulation of the release of catecholamines.
Langer, S. Z. (1980) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06843-7 · Cited by 1,504
Simpson, P., & Savion, S. (1982) · Circulation Research · doi:10.1161/01.res.50.1.101 · Cited by 453
Simpson, P. C., McGrath, A., & Savion, S. (1982) · Circulation Research · doi:10.1161/01.res.51.6.787 · Cited by 429
Studies on isoproterenol-induced cardiomegaly in rats
Stanton, H. C., Brenner, G., & Mayfield, E. D. (1969) · American Heart Journal · doi:10.1016/0002-8703(69)90131-8 · Cited by 216
Östman‐Smith, I. (1981) · Clinical Science · doi:10.1042/cs0610265 · Cited by 182
MacManus, J. P., Braceland, B., Youdale, T., & Whitfield, J. F. (1973) · Journal of Cellular Physiology · doi:10.1002/jcp.1040820204 · Cited by 144
Function of myocardial α-adrenoceptors
Benfey, B. G. (1990) · Life Sciences · doi:10.1016/0024-3205(90)90062-v · Cited by 122
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- Kyncl, J. J., E. N. Bush, and S. A. Buckner. 1982. Alpha adrenergic blocking properties of terazosin. Fed. Proc. 41:1648.
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Molecular and Cellular Events in Myocardial Hypertrophy and Failure
Sawyer, D. B., & Colucci, W. S. (2005) · doi:10.1007/978-1-4757-4558-0_4
Laks, M. M. (1985) · Developments in cardiovascular medicine · doi:10.1007/978-1-4613-2621-2_2
Left ventricle mass index in paediatric intensive care unit acquired hypertension
Mekki, M., Algebaly, H. F., Sabry, H. A., Samir, M., & Rady, H. I. (2023) · Cardiology in the Young · doi:10.1017/s1047951123000781
Left ventricular hypertrophy in chronic kidney disease
Zoccali, C., Bolignano, D., & Mallamaci, F. (2015) · doi:10.1093/med/9780199592548.003.0107_update_002
Strauer, B. E., Motz, W., & Vogt, M. (1991) · Springer eBooks · doi:10.1007/978-3-642-76361-8_11
Regression of Cardiac Hypertrophy with Pharmacotherapeutic Regimen
Motz, W., Vogt, M., Scheler, S., & Strauer, B. E. (1993) · Springer eBooks · doi:10.1007/978-3-642-77891-9_19
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Osaki, T., Mochiduki, A., Nishigori, M., Shinmura, K., Miyazaki, T., Mishiro‐Sato, E., Kadonosono, T., Tamaki, K., Okumura, N., Takao, T., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-43576-8
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Smith, J. L. M., Sturm, G., & Picard, M. A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.09.737569
Scalise, F., Toscano, E., Sorropago, A., Amman, C., & Grassi, G. M. (2026) · Updates in hypertension and cardiovascular protection · doi:10.1007/978-3-032-29564-4_4
Effect of Lisinopril on Hemodynamics and Cardiac Hypertrophy in Rats with Aortocaval Fistula
Oka, T., Nishimura, H., Ueyama, M., Kubota, J., & Kawamura, K. (1992) · Springer eBooks · doi:10.1007/978-4-431-68219-6_29
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Karliner, J. S. (1989) · Springer eBooks · doi:10.1007/978-4-431-67957-8_31
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Böhm, M., & Erdmann, E. (2000) · Springer eBooks · doi:10.1007/978-3-662-12156-6_30
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Metadata
- Authors
- Simpson, P.
- Affiliations
- San Francisco VA Medical Center (US)
- Corresponding author
- Simpson, P
- ORCID
- Simpson, P
- Venue
- Journal of Clinical Investigation
- Published
- 1983-08-01
- Volume
- 72
- Issue
- 2
- Pages
- 732-738
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1129233
- OpenAlex
- W2110889457
- Cited by
- 618
- References
- 20
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 3 · 2013: 10 · 2012: 6
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of California, San Francisco
- National Heart, Lung, and Blood Institute (R01HL031113)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Keywords
- norepinephrine, cardiac hypertrophy, alpha1-adrenoceptors, alpha-blockers, phentolamine, prazosin, terazosin, yohimbine, isoproterenol, propranolol
- MeSH terms
- Adrenergic alpha-Antagonists, Animals, Cardiomegaly, Isoproterenol, Myocardium, Norepinephrine, Phentolamine, Prazosin, Propranolol, Receptors, Adrenergic, Receptors, Adrenergic, alpha, Rats
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