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Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha-1 adrenergic response

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Simpson, P·1983·Journal of Clinical Investigation

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Abstract

We have shown recently that norepinephrine stimulates muscle cell hypertrophy in primary cultures from the neonatal rat ventricle and that this stimulation is not blocked by the beta adrenergic antagonist propranolol. The present study was done to define the adrenergic specificity of the myocyte hypertrophic response to norepinephrine. 90% pure, single-cell cultures of nongrowing myocytes were maintained in serum-free medium 199 with transferin and insulin. Myocyte size was quantitated 48 h after addition of adrenergic agents, by measuring cell volume, cell surface area, and cell protein. L-norepinephrine increased myocyte size to a maximum 150% of control; half-maximum effect was obtained at a concentration of 0.2 microM. This increase in cell size was inhibited by the nonselective alpha adrenergic antagonist phentolamine and by the alpha 1 adrenergic antagonists prazosin and terazosin; it was not inhibited by propranolol or by the alpha 2 adrenergic antagonist yohimbine. The beta adrenergic agonist isoproterenol did not increase cell size. Thus, norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response.

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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Biostatistical Analysis.
Feinleib, M., & Zar, J. H. (1975) · Journal of the American Statistical Association · doi:10.2307/2285423 · Cited by 12,671
Biostatistical analysis
Zar, J. H. (1996) · Cited by 7,837
Presynaptic regulation of the release of catecholamines.
Langer, S. Z. (1980) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06843-7 · Cited by 1,504
Differentiation of rat myocytes in single cell cultures with and without proliferating nonmyocardial cells. Cross-striations, ultrastructure, and chronotropic response to isoproterenol.
Simpson, P., & Savion, S. (1982) · Circulation Research · doi:10.1161/01.res.50.1.101 · Cited by 453
Myocyte hypertrophy in neonatal rat heart cultures and its regulation by serum and by catecholamines.
Simpson, P. C., McGrath, A., & Savion, S. (1982) · Circulation Research · doi:10.1161/01.res.51.6.787 · Cited by 429
Studies on isoproterenol-induced cardiomegaly in rats
Stanton, H. C., Brenner, G., & Mayfield, E. D. (1969) · American Heart Journal · doi:10.1016/0002-8703(69)90131-8 · Cited by 216
Cardiac Sympathetic Nerves as the Final Common Pathway in the Induction of Adaptive Cardiac Hypertrophy
Östman‐Smith, I. (1981) · Clinical Science · doi:10.1042/cs0610265 · Cited by 182
Adrenergic antagonists, and a possible link between the increase in cyclic adenosine 3′,5′‐monophosphate and DNA synthesis during liver regeneration
MacManus, J. P., Braceland, B., Youdale, T., & Whitfield, J. F. (1973) · Journal of Cellular Physiology · doi:10.1002/jcp.1040820204 · Cited by 144
Function of myocardial α-adrenoceptors
Benfey, B. G. (1990) · Life Sciences · doi:10.1016/0024-3205(90)90062-v · Cited by 122

Flagged first, then by citations

Show all 20 references

Research works printed but not linked: 1

Kyncl, J. J., E. N. Bush, and S. A. Buckner. 1982. Alpha adrenergic blocking properties of terazosin. Fed. Proc. 41:1648.

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Zheng, J.-S., Boluyt, M. O., Long, X., O’Neill, L., Lakatta, E. G., & Crow, M. T. (1996) · Circulation Research · doi:10.1161/01.res.78.4.525 · Cited by 58
Adverse effects of constitutively active α1B-adrenergic receptors after pressure overload in mouse hearts
Wang, B. H., Du, X., Autelitano, D. J., Milano, C. A., & Woodcock, E. A. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.279.3.h1079 · Cited by 58
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Mishra, S., Ling, H., Grimm, M. F., Zhang, T., Bers, D. M., & Brown, J. H. (2010) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3181e1d263 · Cited by 56
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Taskiran, M., Rasmussen, V., Rasmussen, B. S., Fritz‐Hansen, T., Larsson, H. B. W., Jensen, G. B., & Hilsted, J. (2004) · Diabetic Medicine · doi:10.1111/j.1464-5491.2004.01145.x · Cited by 56
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Catecholamines in cardiac hypertrophy
Scheuer, J. (1999) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00264-7 · Cited by 55
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Regulation of hypertrophy and atrophy in cultured adult heart cells.
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Authors: Simpson, P.
Affiliations: San Francisco VA Medical Center (US)
Corresponding author: Simpson, P
ORCID: Simpson, P
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1983-08-01
Volume: 72
Issue: 2
Pages: 732-738
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci111023
PMC: PMC1129233
OpenAlex: W2110889457
Cited by: 618
References: 20
Citations by year: 2026: 4 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 3 · 2013: 10 · 2012: 6
FWCI: 3.65
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: University of California, San Francisco
National Heart, Lung, and Blood Institute (R01HL031113)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
Keywords: norepinephrine, cardiac hypertrophy, alpha1-adrenoceptors, alpha-blockers, phentolamine, prazosin, terazosin, yohimbine, isoproterenol, propranolol
MeSH terms: Adrenergic alpha-Antagonists, Animals, Cardiomegaly, Isoproterenol, Myocardium, Norepinephrine, Phentolamine, Prazosin, Propranolol, Receptors, Adrenergic, Receptors, Adrenergic, alpha, Rats

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Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha-1 adrenergic response

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