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Cited by 131Diabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Relationship between obesity and maximal insulin-stimulated glucose uptake in vivo and in vitro in Pima Indians.

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Bogardus, C, Lillioja, S, Mott, D, Reaven, G R, Kashiwagi, A, Foley, J E·1984·Journal of Clinical Investigation
DOI 10.1172/jci111274PMC PMC425083
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Abstract

Previous studies have left unanswered whether human obesity, independent of glucose intolerance, is associated with a "postreceptor" defect in insulin action. We have studied the relationship between the degree of obesity (as estimated by underwater weighing) and the maximal insulin-stimulated glucose disposal rate (M) in vivo in 52 glucose-tolerant Pima Indian males. The relationship was examined independently of differences in age and maximal oxygen uptake (an estimate of "physical fitness"). The maximal insulin-stimulated glucose transport rate (MTR) was also measured in isolated abdominal adipocytes from the same subjects to determine whether differences in M could be explained by differences in glucose transport. The results showed that there was a large variance in M and MTR among these glucose-tolerant subjects. M was better correlated with glucose storage rates than with oxidation rates, as estimated by indirect calorimetry. The most obese subjects had only a 20% lower mean M and 30% lower MTR than the most lean subjects. The lower M in the obese subjects was due to both lower glucose oxidation and storage rates. There was no significant, independent correlation between age or degree of obesity and M or MTR. The maximal oxygen uptake (VO2 max) appeared to independently account for 20% of the variance observed in M. MTR was only weakly correlated with M (r = 0.36, P less than 0.02). We concluded that differences in M in these glucose-tolerant subjects must be explained by factor(s) other than maximal oxygen uptake, age, maximal insulin-stimulated glucose transport in vitro, or degree of adiposity per se.

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  1. [12]12. Astrand, P.-O., and Radahl, K. 1970. Textbook of Work Physiology: Physiological Basis of Exercise. McGraw-Hill, Inc., New York. 447-477.

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Metadata

Authors
Bogardus, C., Lillioja, S., Mott, D., Reaven, G. R., Kashiwagi, A., & Foley, J. E.
Affiliations
National Institutes of Health (US)
ORCID
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1984-03-01
Volume
73
Issue
3
Pages
800-805
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci111274
PMC
PMC425083
OpenAlex
W2049107834
Cited by
131
References
18
Citations by year
2023: 1 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 2 · 2014: 2 · 2013: 6 · 2012: 1
FWCI
6.36
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Research Online (University of Wollongong) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords
obesity, insulin-stimulated glucose uptake, insulin resistance, glucose transport, adipocytes, glucose oxidation, glucose storage, VO2max, Pima Indians, adiposity
MeSH terms
Adipose Tissue, Glucose, Humans, Indians, North American, Insulin, Male, Obesity, In Vitro Techniques

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