The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Continuous administration of synthetic ovine corticotropin-releasing factor in man. Physiological and pathophysiological implications
Open accessAbstract
The continuous 24-h infusion of a maximally stimulating dose (1 micrograms/kg per h) of ovine corticotropin-releasing factor (CRF) in man caused a modest elevation of plasma cortisol (17.2 +/- 1.4 micrograms/dl) and urinary-free cortisol (173 +/- 43 micrograms/24 h) concentrations, which was far less than that seen with a maximally stimulating dose of ACTH (50.4 +/- 2.2 micrograms/dl and 1,200 +/- 94 micrograms/24 h, respectively). The circadian rhythms of plasma ACTH and cortisol were preserved during CRF administration. An intravenous bolus injection of 1 microgram/kg of ovine CRF given to normal volunteers under basal conditions resulted in elevated plasma ACTH and cortisol peak levels (28 +/- 6 pg/ml and 15.0 +/- 1.0 micrograms/dl, respectively). However, no plasma ACTH and cortisol responses were observed when an identical CRF stimulation test was given at the end of the continuous infusion. These findings suggest that the stimulatory activity of exogenous CRF on the ACTH-secreting cells of the pituitary gland is restrained by the negative feedback of cortisol. The persistent circadian rhythm of ACTH, despite a constant level of plasma CRF during the infusion, suggests that the circadian variation in the activity of the hypothalamic-pituitary-adrenal axis cannot be explained solely by circadian periodicity of the endogenous CRF stimulus.
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Cites
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Vale, W., Spiess, J., RIVIER, C. L., & Rivier, J. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198205000-00013 · Cited by 3,904
Rodbard, D. (1974) · Clinical Chemistry · doi:10.1093/clinchem/20.10.1255 · Cited by 1,043
Corticotropin releasing activity of the new CRF is potentiated several times by vasopressin
Gillies, G. E., Linton, E. A., & Lowry, P. J. (1982) · Nature · doi:10.1038/299355a0 · Cited by 965
Disrupted 24-hour patterns of cortisol secretion in psychotic depression
Sachar, E. J. (1973) · Archives of General Psychiatry · doi:10.1001/archpsyc.1973.01750310011002 · Cited by 775
TESTS OF PITUITARY-ADRENAL SUPPRESSIBILITY IN THE DIAGNOSIS OF CUSHING'S SYNDROME*
Liddle, G. W. (1960) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-20-12-1539 · Cited by 732
Neuroendocrine Regulation in Depression
Carroll, B. J. (1976) · Archives of General Psychiatry · doi:10.1001/archpsyc.1976.01770090041003 · Cited by 638
Neuroendocrine Regulation in Depression
Carroll, B. J. (1976) · Archives of General Psychiatry · doi:10.1001/archpsyc.1976.01770090029002 · Cited by 622
VALE, W., VAUGHAN, J., SMITH, M., & YAMAMOTO, G. (1983) · Endocrinology · doi:10.1210/endo-113-3-1121 · Cited by 563 · cited 3×
“Synergy with other factors, as suggested by other authors (2-9), or an augmented ACTH response to pulsed rather than continuous endogenous CRFsecretion may account for the higher levels seen in stress.”
BackgroundRivier, C., & Vale, W. (1983) · Nature · doi:10.1038/305325a0 · Cited by 539
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Research works printed but not linked: 1
- [10]10. Yates, F. E., and J. W. Maran. 1974. Handbook of Physiology, Section 7, Endocrinology IV, part 2, Washington, D. C. American Physiological Society, pp. 367-404.
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(1991) · The Lancet · doi:10.1016/0140-6736(91)93266-c
Pereira, A. M., & Dekkers, O. M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-99899-4.00006-8
Regulation and Actions of Corticotropin‐Releasing Hormone
Weninger, S. C., & Majzoub, J. A. (2000) · Comprehensive physiology · doi:10.1002/j.2040-4603.2000.tb01511.x
Metadata
- Authors
- Schulte, H. M., Chrousos, G. P., Gold, P. W., Booth, J. D., Oldfield, E. H., Cutler, G. B., & Loriaux, D. L.
- Affiliations
- National Institutes of Health (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1985-06-01
- Volume
- 75
- Issue
- 6
- Pages
- 1781-1785
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC425532
- OpenAlex
- W2079168311
- Semantic Scholar
- d8393d0a8716751e9308c2905547bd157a4dff83
- Cited by
- 103
- References
- 36
- Citations by year
- 2022: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2013: 1
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- corticotropin-releasing factor, ovine CRF, continuous infusion, ACTH secretion, cortisol, hypothalamic-pituitary-adrenal axis, negative feedback, circadian rhythm, ACTH stimulation test
- MeSH terms
- Adrenal Glands, Adrenocorticotropic Hormone, Adult, Animals, Circadian Rhythm, Corticotropin-Releasing Hormone, Cushing Syndrome, Female, Hormones, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Middle Aged, Secretory Rate, Sheep
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