Cited by 103Stress Responses and CortisolAdrenal Hormones and DisordersHypothalamic control of reproductive hormones

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Continuous administration of synthetic ovine corticotropin-releasing factor in man. Physiological and pathophysiological implications

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Schulte, H M, Chrousos, G P, Gold, P W, Booth, J D, Oldfield, E H, Cutler, G B, Loriaux, D L·1985·Journal of Clinical Investigation

DOI 10.1172/jci111890PMC PMC425532

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Abstract

The continuous 24-h infusion of a maximally stimulating dose (1 micrograms/kg per h) of ovine corticotropin-releasing factor (CRF) in man caused a modest elevation of plasma cortisol (17.2 +/- 1.4 micrograms/dl) and urinary-free cortisol (173 +/- 43 micrograms/24 h) concentrations, which was far less than that seen with a maximally stimulating dose of ACTH (50.4 +/- 2.2 micrograms/dl and 1,200 +/- 94 micrograms/24 h, respectively). The circadian rhythms of plasma ACTH and cortisol were preserved during CRF administration. An intravenous bolus injection of 1 microgram/kg of ovine CRF given to normal volunteers under basal conditions resulted in elevated plasma ACTH and cortisol peak levels (28 +/- 6 pg/ml and 15.0 +/- 1.0 micrograms/dl, respectively). However, no plasma ACTH and cortisol responses were observed when an identical CRF stimulation test was given at the end of the continuous infusion. These findings suggest that the stimulatory activity of exogenous CRF on the ACTH-secreting cells of the pituitary gland is restrained by the negative feedback of cortisol. The persistent circadian rhythm of ACTH, despite a constant level of plasma CRF during the infusion, suggests that the circadian variation in the activity of the hypothalamic-pituitary-adrenal axis cannot be explained solely by circadian periodicity of the endogenous CRF stimulus.

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Authors: Schulte, H. M., Chrousos, G. P., Gold, P. W., Booth, J. D., Oldfield, E. H., Cutler, G. B., & Loriaux, D. L.
Affiliations: National Institutes of Health (US)
ORCID: Chrousos, G P
Gold, P W
Cutler, G B
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1985-06-01
Volume: 75
Issue: 6
Pages: 1781-1785
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci111890
PMC: PMC425532
OpenAlex: W2079168311
Semantic Scholar: d8393d0a8716751e9308c2905547bd157a4dff83
Cited by: 103
References: 36
Citations by year: 2022: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2013: 1
FWCI: 3.92
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: corticotropin-releasing factor, ovine CRF, continuous infusion, ACTH secretion, cortisol, hypothalamic-pituitary-adrenal axis, negative feedback, circadian rhythm, ACTH stimulation test
MeSH terms: Adrenal Glands, Adrenocorticotropic Hormone, Adult, Animals, Circadian Rhythm, Corticotropin-Releasing Hormone, Cushing Syndrome, Female, Hormones, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Middle Aged, Secretory Rate, Sheep

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Continuous administration of synthetic ovine corticotropin-releasing factor in man. Physiological and pathophysiological implications

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