The DOI matches its Crossref record.
Primary structures of three human neutrophil defensins.
Open accessAbstract
The primary structures of three human neutrophil antimicrobial peptides (HNP) were determined. The peptides, HNP-1, HNP-2, and HNP-3, which we have termed defensins, were rich in cystine, arginine, and aromatic residues, but were devoid of free sulfhydryl groups and carbohydrate moieties. They were 29-30 residues in length and identical in sequence in all but their amino terminal residues. The defensins were homologous in sequence to peptides of similar size and biological activity previously purified from rabbit polymorphonuclear leukocytes, but unrelated to other neutrophil proteins of known sequence. 11 amino acid residues of the human defensins, including all six cysteinyl residues, were invariantly conserved in the six rabbit members of this multigene peptide family. That similarly structured antimicrobial peptides are present in both rabbit and human leukocytes supports their purported role as cidal agents in phagocyte-mediated host defense.
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Citations
Cited by
Antimicrobial peptides of multicellular organisms
Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457
Defensins: antimicrobial peptides of innate immunity
Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066
Self-citationAPD3: the antimicrobial peptide database as a tool for research and education
Wang, G., Li, X., & Wang, Z. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1278 · Cited by 2,388
Direct inactivation of viruses by human granulocyte defensins
Daher, K. A., Selsted, M. E., & Lehrer, R. I. (1986) · Journal of Virology · doi:10.1128/jvi.60.3.1068-1074.1986 · Cited by 533
Self-citationKagan, B. L., Selsted, M. E., Ganz, T., & Lehrer, R. I. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.1.210 · Cited by 532
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Metadata
- Authors
- Selsted, M. E., Harwig, S. S., Ganz, T., Schilling, J. W., & Lehrer, R. I.
- Venue
- Journal of Clinical Investigation
- Published
- 1985-10-01
- Volume
- 76
- Issue
- 4
- Pages
- 1436-1439
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2022577580
- Cited by
- 534
- References
- 0
- FWCI
- 14.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Selsted, M. E., Harwig, S. S., Ganz, T., Schilling, J. W., & Lehrer, R. I. (1985). Primary structures of three human neutrophil defensins. Journal of Clinical Investigation. https://doi.org/10.1172/jci112121
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