The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Direct inactivation of viruses by human granulocyte defensins
Open accessAbstract
Human neutrophils contain a family of microbicidal peptides known as defensins. One of these defensins, human neutrophil peptide (HNP)-1, was purified, and its ability to directly inactivate several viruses was extensively tested. Herpes simplex virus (HSV) types 1 and 2, cytomegalovirus, vesicular stomatitis virus, and influenza virus A/WSN were inactivated by incubation with HNP-1. Two nonenveloped viruses, echovirus type 11 and reovirus type 3, were resistant to inactivation. Purified homologous peptides HNP-2 and HNP-3 were found to have HSV-1-neutralizing activities approximately equal to that of HNP-1. Inactivation of HSV-1 by HNP-1 depended on the time, temperature, and pH of incubation. Antiviral activity was abrogated by low temperature or prior reduction and alkylation of the defensins. Addition of serum or serum albumin to the incubation mixtures inhibited neutralization of HSV-1 by HNP-1. We used density gradient sedimentation techniques to demonstrate that HNP-1 bound to HSV-1 in a temperature-dependent manner. We speculate that binding of defensin peptides to certain viruses may impair their ability to infect cells.
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Cites
Oxygen-Dependent Microbial Killing by Phagocytes: (First of Two Parts)
Babior, B. M. (1978) · New England Journal of Medicine · doi:10.1056/nejm197803232981205 · Cited by 2,486
High resolution acrylamide gel electrophoresis of histones
Panyim, S., & Chalkley, R. (1969) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(69)90042-3 · Cited by 2,453
Defensins. Natural peptide antibiotics of human neutrophils.
Ganz, T., Selsted, M. E., Szklarek, D., Harwig, S. S., Daher, K., Bainton, D. F., & Lehrer, R. I. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112120 · Cited by 1,416
Self-citationThe neutrophil: Function and clinical disorders
Clark, R. A., & Klebanoff, S. J. (1978) · Cited by 669
Primary structures of three human neutrophil defensins.
Selsted, M. E., Harwig, S. S., Ganz, T., Schilling, J. W., & Lehrer, R. I. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112121 · Cited by 534
Self-citationPrimary structures of MCP-1 and MCP-2, natural peptide antibiotics of rabbit lung macrophages.
Selsted, M. E., Brown, D. M., DeLange, R. J., & Lehrer, R. I. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43888-9 · Cited by 205
Self-citationLehrer, R. I., Daher, K., Ganz, T., & Selsted, M. E. (1985) · Journal of Virology · doi:10.1128/jvi.54.2.467-472.1985 · Cited by 182
Self-citationElsbach, P., & Weiss, J. P. (1983) · Clinical Infectious Diseases · doi:10.1093/clinids/5.5.843 · Cited by 143
Lehrer, R. I., Ladra, K. M., & Hake, R. B. (1975) · Infection and Immunity · doi:10.1128/iai.11.6.1226-1234.1975 · Cited by 128
Self-citationCorrelation of binding of rabbit granulocyte peptides to Candida albicans with candidacidal activity
Lehrer, R. I., Szklarek, D., Ganz, T., & Selsted, M. E. (1985) · Infection and Immunity · doi:10.1128/iai.49.1.207-211.1985 · Cited by 102
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Cited by
Defensins: antimicrobial peptides of innate immunity
Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066
Antimicrobial host defence peptides: functions and clinical potential
Mookherjee, N., Anderson, M. A., Haagsman, H. P., & Davidson, D. J. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0058-8 · Cited by 1,502
Neutrophil granules and secretory vesicles in inflammation
Faurschou, M., & Borregaard, N. (2003) · Microbes and Infection · doi:10.1016/j.micinf.2003.09.008 · Cited by 1,162
Defensins: Antimicrobial and Cytotoxic Peptides of Mammalian Cells
Lehrer, R. I., Lichtenstein, A. K., & Ganz, T. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.000541 · Cited by 991
Self-citationKagan, B. L., Selsted, M. E., Ganz, T., & Lehrer, R. I. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.1.210 · Cited by 532
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Metadata
- Authors
- Daher, K. A., Selsted, M. E., & Lehrer, R. I.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1986-12
- Volume
- 60
- Issue
- 3
- Pages
- 1068-1074
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2130703653
- Cited by
- 533
- References
- 16
- FWCI
- 7.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Daher, K. A., Selsted, M. E., & Lehrer, R. I. (1986). Direct inactivation of viruses by human granulocyte defensins. Journal of Virology. https://doi.org/10.1128/jvi.60.3.1068-1074.1986
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
