The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Efficient clearance of non-transferrin-bound iron by rat liver. Implications for hepatic iron loading in iron overload states.
Open accessAbstract
In hemochromatosis and other disorders associated with iron overload, a significant fraction of the total iron in plasma circulates in the form of low molecular weight complexes not bound to transferrin. Efficient and unregulated clearance of this form of iron by the liver may account for the hepatic iron loading and toxicity that characterize these diseases. We tested this possibility by examining the hepatic removal process for representative iron complexes in the single-pass perfused rat liver. Hepatic uptake of both ferrous and ferric 55Fe from ultrafiltered human serum was found to be highly efficient and effectively irreversible (single-pass extraction of 1 microM iron, 58-75%). Similar high efficiencies were seen for iron complexed to specific physiologic and nonphysiologic coordinators, including histidine, citrate, fructose, oxalate and glutamate, and tricine. Because of lower plasma flow rates, single-pass extraction of these iron complexes in vivo should be even greater. Autoradiography confirmed that most iron had been removed by parenchymal cells. Hepatic removal from Krebs-tricine buffer was saturable with similar kinetic parameters for ferrous and ferric iron (apparent Km, 14-22 microM; V max, 24-38 nmol min-1 g liver-1). These findings suggest that high levels of non-transferrin-bound iron in plasma may be an important cause of hepatic iron loading in iron overload states.
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Cites
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Cited by
Non-transferrin bound iron: a key role in iron overload and iron toxicity
Brissot, P., Ropert, M., Le Lan, C., & Loréal, O. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.07.014 · Cited by 654
Self-citationZip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells
Liuzzi, J. P., Aydemir, F., Nam, H., Knutson, M. D., & Cousins, R. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606424103 · Cited by 577
Brissot, P., Pietrangelo, A., Adams, P. C., de Graaff, B., McLaren, C. E., & Loréal, O. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.16 · Cited by 430
Self-citationIron trafficking inside the brain
Moos, T., Nielsen, T. R., Skjørringe, T., & Morgan, E. H. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04976.x · Cited by 420
Craven, C. M., Alexander, J., Eldridge, M., Kushner, J. P., Bernstein, S., & Kaplan, J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.10.3457 · Cited by 259
Metadata
- Authors
- Brissot, P., Wright, T. L., Ma, W. L., & Weisiger, R. A.
- Venue
- Journal of Clinical Investigation
- Published
- 1985-10-01
- Volume
- 76
- Issue
- 4
- Pages
- 1463-1470
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2091806624
- Cited by
- 256
- References
- 20
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Brissot, P., Wright, T. L., Ma, W. L., & Weisiger, R. A. (1985). Efficient clearance of non-transferrin-bound iron by rat liver. Implications for hepatic iron loading in iron overload states. Journal of Clinical Investigation. https://doi.org/10.1172/jci112125
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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