The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Myocardial metabolism of free fatty acids. Studies with 14C-labeled substrates in humans.
Open accessAbstract
Free fatty acids are considered to be the major energy source for the myocardium. To investigate the metabolic fate of this substrate in humans, 24 subjects underwent coronary sinus and arterial catheterization. 13 subjects were healthy volunteers and 11 subjects had symptoms of ischemic heart disease. [1-14C]oleate or [1-14C]palmitate bound to albumin was infused at a constant rate of 25 microCi/h. Oxidation was determined by measuring the 14CO2 production. The data demonstrated that a high percentage (84 +/- 17%) of the palmitate and oleate extracted by the myocardium underwent rapid oxidation. A highly significant correlation was present between the arterial level and the amount oxidized (r = 0.82, P less than 0.001 for palmitate; r = 0.77, P less than 0.001 for oleate). The isotope extraction ratio was greater than the chemical extraction ratio. This difference of 6 +/- 2 nmol/ml of blood in the young normal subjects was significantly less than the 12 +/- 4 nmol/ml observed in the ischemic heart disease patients (P less than 0.001).
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Borlaug, B. A., Jensen, M. D., Kitzman, D. W., Lam, C. S. P., Obokata, M., & Rider, O. J. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvac120 · Cited by 450
Energy Metabolism in the Normal and Failing Heart: Potential for Therapeutic Interventions
Stanley, W. C., & Chandler, M. P. (2002) · Heart Failure Reviews · doi:10.1023/a:1015320423577 · Cited by 271
Lactate in contemporary biology: a phoenix risen
Brooks, G. A., Arevalo, J. A., Osmond, A. D., Leija, R. G., Curl, C. C., & Tovar, A. P. (2022) · The Journal of Physiology · doi:10.1113/jp280955 · Cited by 269
‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk
Aldiss, P., Davies, G., Woods, R., Budge, H., Sacks, H. S., & Symonds, M. E. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.11.074 · Cited by 148
Free Fatty Acid Uptake in Humans With CD36 Deficiency
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Metadata
- Authors
- Wisneski, J. A., Gertz, E. W., Neese, R. A., & Mayr, M.
- Venue
- Journal of Clinical Investigation
- Published
- 1987-02-01
- Volume
- 79
- Issue
- 2
- Pages
- 359-366
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2120138860
- Cited by
- 286
- References
- 34
- FWCI
- 6.60
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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