‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk
Open accessAbstract
Excess visceral adiposity, in particular that located adjacent to the heart and coronary arteries is associated with increased cardiovascular risk. In the pathophysiological state, dysfunctional adipose tissue secretes an array of factors modulating vascular function and driving atherogenesis. Conversely, brown and beige adipose tissues utilise glucose and lipids to generate heat and are associated with improved cardiometabolic health. The cardiac and thoracic perivascular adipose tissues are now understood to be composed of brown adipose tissue in the healthy state and undergo a brown-to-white transition i.e. during obesity which may be a driving factor of cardiovascular disease. In this review we discuss the risks of excess cardiac and vascular adiposity and potential mechanisms by which restoring the brown phenotype i.e. "re-browning" could potentially be achieved in clinically relevant populations.
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The interrelation of pericoronary fat with vasomotor function is mediated by the release of vasoactive factors such as leptin and adiponectin.
“Thus, an interrelation of pericoronary fat with vasomotor function is mediated by the release of specific vasoactive factors such as leptin and adiponectin among others [41,42].”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [41]
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- Authors
- Aldiss, P., Davies, G., Woods, R., Budge, H., Sacks, H. S., & Symonds, M. E.
- Affiliations
- University of Nottingham (GB)
- VA Greater Los Angeles Healthcare System (US)
- Corresponding author
- Symonds, Michael E.
- Venue
- International Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 228
- Pages
- 265-274
- ISSN
- 0167-5273 (ISSN-L)
- PMC
- PMC5236060
- OpenAlex
- W2551225596
- Cited by
- 148
- References
- 177
- Citations by year
- 2026: 12 · 2025: 10 · 2024: 19 · 2023: 12 · 2022: 11 · 2021: 18 · 2020: 20 · 2019: 19 · 2018: 12 · 2017: 13 · 2016: 1
- FWCI
- 12.37
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- International Journal of Cardiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
- Nottingham ePrints (University of Nottingham) (submittedVersion, cc-by)
- Funders
- British Heart Foundation (FS/15/4/31184)
- University of Nottingham
- Cardiometabolic Research Foundation, Los Angeles (CRFLAPhD2012)
- BBSRC (BBSRCBB/I016015/1)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- brown adipose tissue, beige adipose tissue, cardiac adipose tissue, perivascular adipose tissue, visceral fat, cardiovascular risk, obesity, atherogenesis, cardiometabolic health, thermogenesis
- MeSH terms
- Adipose Tissue, Beige, Adipose Tissue, Brown, Cardiovascular Diseases, Coronary Artery Disease, Female, Humans, Male, Obesity, Prognosis, Body Mass Index, Risk Assessment, Intra-Abdominal Fat, Adiposity
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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