The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Mechanisms for defects in muscle protein metabolism in rats with chronic uremia. Influence of metabolic acidosis.
Open accessAbstract
Chronic renal failure (CRF) is associated with metabolic acidosis and abnormal muscle protein metabolism. As we have shown that acidosis by itself stimulates muscle protein degradation by a glucocorticoid-dependent mechanism, we assessed the contribution of acidosis to changes in muscle protein turnover in CRF. A stable model of uremia was achieved in partially nephrectomized rats (plasma urea nitrogen, 100-120 mg/dl, blood bicarbonate less than 21 meq/liter). CRF rats excreted 22% more nitrogen than pair-fed controls (P less than 0.005), so muscle protein synthesis and degradation were measured in perfused hindquarters. CRF rats had a 90% increase in net protein degradation (P less than 0.001); this was corrected by dietary bicarbonate. Correction of acidosis did not reduce the elevated corticosterone excretion rate of CRF rats, nor did it improve a second defect in muscle protein turnover, a 34% lower rate of insulin-stimulated protein synthesis. Thus, abnormal nitrogen production in CRF is due to accelerated muscle proteolysis caused by acidosis and an acidosis-independent inhibition of insulin-stimulated muscle protein synthesis.
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Cites
HINDLIMB MUSCLE FIBER POPULATIONS OF FIVE MAMMALS
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May, R. C., Kelly, R. A., & Mitch, W. E. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112344 · Cited by 372
Self-citationRegulation by insulin of amino acid release and protein turnover in the perfused rat hemicorpus.
Jefferson, L. S., Li, J. B., & Rannels, S. R. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40681-8 · Cited by 293
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Hyperglucagonemia of Renal Failure
Bilbrey, G. L., Faloona, G. R., White, M. G., Knochel, J. P., & Borroto, J. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107624 · Cited by 163
Effects of glucocorticoids on muscle protein turnover in perfused rat hemicorpus
Rannels, S. R., & Jefferson, L. S. (1980) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1980.238.6.e564 · Cited by 147
Effects of Parathyroid Hormone on Skeletal Muscle Protein and Amino Acid Metabolism in the Rat
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Cited by
Lecker, S. H., Solomon, V., Mitch, W. E., & Goldberg, A. L. (1999) · The Journal of Nutrition · doi:10.1093/jn/129.1.227s · Cited by 732
Self-citationPrice, S. R., Bailey, J. L., Wang, X., Jurkovitz, C., England, B. K., Ding, X., Phillips, L. S., & Mitch, W. E. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118968 · Cited by 349
Self-citationHemodialysis stimulates muscle and whole body protein loss and alters substrate oxidation
Ikizler, T. A., Pupim, L. B., Brouillette, J. R., Levenhagen, D. K., Farmer, K., Hakim, R. M., & Flakoll, P. J. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2002.282.1.e107 · Cited by 326
Myostatin/activin pathway antagonism: molecular basis and therapeutic potential
Han, H. Q., Zhou, X., Mitch, W. E., & Goldberg, A. L. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.05.019 · Cited by 314
Self-citationMetabolic Acidosis of CKD: An Update
Kraut, J. A., & Madias, N. E. (2016) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2015.08.028 · Cited by 314
Metadata
- Authors
- May, R. C., Kelly, R. A., & Mitch, W. E.
- Venue
- Journal of Clinical Investigation
- Published
- 1987-04-01
- Volume
- 79
- Issue
- 4
- Pages
- 1099-1103
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2096523173
- Cited by
- 324
- References
- 19
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- green
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