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Seminal vesicle-secreted proteins and their reactions during gelation and liquefaction of human semen.
Open accessAbstract
The comparison of measurements of fibronectin and lactoferrin in ejaculates from vasectomized men, subjects with functional deficiency or aplasia of the seminal vesicles, and reference subjects provided evidence that both the fibronectin and the lactoferrin in human seminal fluid originate from the seminal vesicles and the ampullae. The fibronectin is incorporated in the framework of the seminal gel formed during the immediate postejaculatory phase, whereas the lactoferrin remains in solution. In the seminal gel fibronectin is linked to its predominant structural protein, a high molecular weight seminal vesicle protein (semenogelin). Both the gel-bound fibronectin and semenogelin are progressively fragmented and solubilized by the abundant prostatic kallikrein-like protease (prostate-specific antigen) during and after seminal gel liquefaction. Lactoferrin remains essentially unaffected by the seminal proteases.
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Cited by
Prostate-specific antigen in serum occurs predominantly in complex with alpha 1-antichymotrypsin
Lilja, H., Christensson, A., Dahlén, U., Matikainen, M. T., Nilsson, O., Pettersson, K., & Lövgren, T. (1991) · Clinical Chemistry · doi:10.1093/clinchem/37.9.1618 · Cited by 910
Self-citationBiology of Prostate-Specific Antigen
Balk, S. P., Ko, Y.-J., & Bubley, G. J. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.02.083 · Cited by 718
Uludag, Y., & Tothill, I. E. (2012) · Analytical Chemistry · doi:10.1021/ac300278p · Cited by 290
Beyond the biomarker role: prostate-specific antigen (PSA) in the prostate cancer microenvironment
Moradi, A., Srinivasan, S., Clements, J., & Batra, J. (2019) · Cancer and Metastasis Reviews · doi:10.1007/s10555-019-09815-3 · Cited by 114
Shang, Z., Niu, Y., Cai, Q., Chen, J., Tian, J., Yeh, S., Lai, K.-P., & Chang, C. (2014) · Tumor Biology · doi:10.1007/s13277-013-1253-6 · Cited by 66
Metadata
- Authors
- Lilja, H., Oldbring, J., Rannevik, G., & Laurell, C. B.
- Venue
- Journal of Clinical Investigation
- Published
- 1987-08-01
- Volume
- 80
- Issue
- 2
- Pages
- 281-285
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2031383072
- Cited by
- 395
- References
- 0
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lilja, H., Oldbring, J., Rannevik, G., & Laurell, C. B. (1987). Seminal vesicle-secreted proteins and their reactions during gelation and liquefaction of human semen. Journal of Clinical Investigation. https://doi.org/10.1172/jci113070
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