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Seminal vesicle-secreted proteins and their reactions during gelation and liquefaction of human semen.

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Lilja, H, Oldbring, J, Rannevik, G, Laurell, C B·1987·Journal of Clinical Investigation

Abstract

The comparison of measurements of fibronectin and lactoferrin in ejaculates from vasectomized men, subjects with functional deficiency or aplasia of the seminal vesicles, and reference subjects provided evidence that both the fibronectin and the lactoferrin in human seminal fluid originate from the seminal vesicles and the ampullae. The fibronectin is incorporated in the framework of the seminal gel formed during the immediate postejaculatory phase, whereas the lactoferrin remains in solution. In the seminal gel fibronectin is linked to its predominant structural protein, a high molecular weight seminal vesicle protein (semenogelin). Both the gel-bound fibronectin and semenogelin are progressively fragmented and solubilized by the abundant prostatic kallikrein-like protease (prostate-specific antigen) during and after seminal gel liquefaction. Lactoferrin remains essentially unaffected by the seminal proteases.

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Metadata

Authors
Lilja, H., Oldbring, J., Rannevik, G., & Laurell, C. B.
Venue
Journal of Clinical Investigation
Published
1987-08-01
Volume
80
Issue
2
Pages
281-285
ISSN
0021-9738 (ISSN-L)
OpenAlex
W2031383072
Cited by
395
References
0
FWCI
5.89
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Seminal vesicle-secreted proteins and their reactions during gelation and liquefaction of human semen. https://app.cochat.ai/papers/10.1172/jci113070
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Lilja, H., Oldbring, J., Rannevik, G., & Laurell, C. B. (1987). Seminal vesicle-secreted proteins and their reactions during gelation and liquefaction of human semen. Journal of Clinical Investigation. https://doi.org/10.1172/jci113070

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.