The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Peritubular cells are the site of erythropoietin synthesis in the murine hypoxic kidney.
Open accessAbstract
Erythropoietin (Epo)-producing cells were identified in the murine hypoxic kidney by in situ hybridization. Profound anemia was induced in order to greatly increase Epo production. This resulted in high levels of Epo mRNA in the kidney. 35S-labeled DNA fragments of the murine Epo gene were used as probes for in situ hybridization. Control experiments conducted in parallel included kidneys of nonanemic mice, RNase-treated hypoxic kidney sections, and 35S-labeled non-Epo-related DNA. The Epo probe gave a specific hybridization signal in the hypoxic kidney in the cortex and to a lesser extent in the outer medulla. Glomerular and tubular cells were not labeled. All positive cells were identified as peritubular cells. Using immunofluorescence, we showed that cells with the same topography contained Factor VIII-related antigen. These data demonstrated that peritubular cells, most likely endothelial cells, constitute the major site of Epo production in the murine hypoxic kidney.
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Citations
Cites
Role of the kidney in erythropoiesis
JACOBSON, L. O., GOLDWASSER, E., FRIED, W., & PLZAK, L. (1957) · Nature · doi:10.1038/179633a0 · Cited by 862
Cited by
Krantz, S. (1991) · Blood · doi:10.1182/blood.v77.3.419.419 · Cited by 855
Regulation of erythropoiesis by hypoxia-inducible factors
Haase, V. H. (2013) · Blood Reviews · doi:10.1016/j.blre.2012.12.003 · Cited by 787
Wang, G., & Semenza, G. (1993) · Blood · doi:10.1182/blood.v82.12.3610.3610 · Cited by 766
NEW INSIGHTS INTO ERYTHROPOIESIS: The Roles of Folate, Vitamin B12, and Iron
Koury, M. J., & Ponka, P. (2004) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132306 · Cited by 486
Hypoxic regulation of erythropoiesis and iron metabolism
Haase, V. H. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00174.2010 · Cited by 347
Metadata
- Authors
- Lacombe, C., Da Silva, J. L., Bruneval, P., Fournier, J. G., Wendling, F., Casadevall, N., Camilleri, J. P., Bariety, J., Varet, B., & Tambourin, P.
- Venue
- Journal of Clinical Investigation
- Published
- 1988-02-01
- Volume
- 81
- Issue
- 2
- Pages
- 620-623
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2144795074
- Cited by
- 440
- References
- 1
- FWCI
- 21.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lacombe, C., Da Silva, J. L., Bruneval, P., Fournier, J. G., Wendling, F., Casadevall, N., Camilleri, J. P., Bariety, J., Varet, B., & Tambourin, P. (1988). Peritubular cells are the site of erythropoietin synthesis in the murine hypoxic kidney. Journal of Clinical Investigation. https://doi.org/10.1172/jci113363
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
