The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
NEW INSIGHTS INTO ERYTHROPOIESIS: The Roles of Folate, Vitamin B12, and Iron
Abstract
▪ Abstract Erythropoiesis is the process in which new erythrocytes are produced. These new erythrocytes replace the oldest erythrocytes (normally about one percent) that are phagocytosed and destroyed each day. Folate, vitamin B 12, and iron have crucial roles in erythropoiesis. Erythroblasts require folate and vitamin B 12 for proliferation during their differentiation. Deficiency of folate or vitamin B 12 inhibits purine and thymidylate syntheses, impairs DNA synthesis, and causes erythroblast apoptosis, resulting in anemia from ineffective erythropoiesis. Erythroblasts require large amounts of iron for hemoglobin synthesis. Large amounts of iron are recycled daily with hemoglobin breakdown from destroyed old erythrocytes. Many recently identified proteins are involved in absorption, storage, and cellular export of nonheme iron and in erythroblast uptake and utilization of iron. Erythroblast heme levels regulate uptake of iron and globin synthesis such that iron deficiency causes anemia by retarded production rates with smaller, less hemoglobinized erythrocytes.
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Cites
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
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THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases
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Hepcidin, a urinary antimicrobial peptide synthesized in the liver
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Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
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A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism
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Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
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Cited by
Vitamin B12, folic acid, and the nervous system
Reynolds, E. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70598-1 · Cited by 860
Morris, M. S., Jacques, P. F., Rosenberg, I. H., & Selhub, J. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.1.193 · Cited by 608
Copper and iron disorders of the brain
Madsen, E., & Gitlin, J. D. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094232 · Cited by 557
Nramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivo
Soe-Lin, S., Apte, S. S., Andriopoulos, B., Andrews, M. C., Schranzhofer, M., Kahawita, T., Garcia-Santos, D., & Ponka, P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900808106 · Cited by 167
Self-citationEilander, A., Gera, T., Sachdev, H. S., Transler, C., van der Knaap, H. C., Kok, F. J., & Osendarp, S. J. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28376 · Cited by 148
Metadata
- Authors
- Koury, M. J., & Ponka, P.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2004-07-14
- Volume
- 24
- Issue
- 1
- Pages
- 105-131
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2130190421
- Cited by
- 486
- References
- 100
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: NEW INSIGHTS INTO ERYTHROPOIESIS: The Roles of Folate, Vitamin B12, and Iron. https://app.cochat.ai/papers/10.1146/annurev.nutr.24.012003.132306
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- Koury, M. J., & Ponka, P. (2004). NEW INSIGHTS INTO ERYTHROPOIESIS: The Roles of Folate, Vitamin B12, and Iron. Annual Review of Nutrition. https://doi.org/10.1146/annurev.nutr.24.012003.132306
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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