Cited by 347Erythropoietin and Anemia TreatmentHemoglobin structure and functionCancer, Hypoxia, and Metabolism

Hypoxic regulation of erythropoiesis and iron metabolism

Open access
Haase, Volker H.·2010·American Journal of Physiology-Renal Physiology

Abstract

The kidney is a highly sensitive oxygen sensor and plays a central role in mediating the hypoxic induction of red blood cell production. Efforts to understand the molecular basis of oxygen-regulated erythropoiesis have led to the identification of erythropoietin (EPO), which is essential for normal erythropoiesis and to the purification of hypoxia-inducible factor (HIF), the transcription factor that regulates EPO synthesis and mediates cellular adaptation to hypoxia. Recent insights into the molecular mechanisms that control and integrate cellular and systemic erythropoiesis-promoting hypoxia responses and their potential as a therapeutic target for the treatment of renal anemia are discussed in this review.

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Authors
Haase, V. H.
Affiliations
Vanderbilt University (US)
Corresponding author
Haase, Volker H.
Venue
American Journal of Physiology-Renal Physiology
Published
2010-07
Volume
299
Issue
1
Pages
F1-F13
ISSN
  • 1522-1466 (ISSN-L)
  • 1931-857X
OpenAlex
W2157705760
Cited by
347
References
174
Citations by year
2026: 13 · 2025: 31 · 2024: 22 · 2023: 20 · 2022: 26 · 2021: 25 · 2020: 25 · 2019: 16 · 2018: 15 · 2017: 18 · 2016: 18 · 2015: 20 · 2014: 24 · 2013: 29 · 2012: 20
FWCI
3.74
Type
journal article
Language
en
Open access
Locations
  • American Journal of Physiology-Renal Physiology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK080821, R01DK081646)
Topics
  • Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords
hypoxia, erythropoiesis, iron metabolism, erythropoietin, hypoxia-inducible factor, oxygen sensing, kidney, anemia of chronic kidney disease, transcriptional regulation, therapeutic target
MeSH terms
Endothelial PAS Domain-Containing Protein 1, Anemia, Animals, Hypoxia, Bone Marrow, Erythrocytes, Erythropoiesis, Erythropoietin, Gene Expression Regulation, Hematinics, Homeostasis, Humans, Iron, Kidney, Oxygen, Polycythemia, Procollagen-Proline Dioxygenase, Protein Processing, Post-Translational, Basic Helix-Loop-Helix Proteins, Von Hippel-Lindau Tumor Suppressor Protein

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