The DOI matches its Crossref record.
Antigen CD34+ marrow cells engraft lethally irradiated baboons.
Open accessAbstract
The CD34 antigen is present on 1-4% of human marrow cells including virtually all hematopoietic progenitors detected by in vitro assays. Since the anti-CD34 monoclonal antibody 12-8 reacts with a similar marrow population in baboons, it was possible to test whether this antigen is expressed by stem cells responsible for hematopoietic reconstitution in vivo. CD34+ cells were enriched from marrows of five baboons using avidin-biotin immunoadsorption. After lethal irradiation, the five animals were given 15-27 X 10(6) autologous marrow cells (3.2-4.4 X 10(6) cells/kg) containing 65-91% CD34+ cells. All animals achieved granulocyte counts greater than 1,000/mm3 and platelet counts greater than 20 X 10(3)/mm3 by 13-24 d posttransplant and subsequently developed normal peripheral blood counts. Two additional animals received 184 and 285 X 10(6) marrow cells/kg depleted of CD34+ cells. One animal died at day 29 without engraftment, while the other had pancytopenia for greater than 100 d posttransplant. The data suggest that stem cells responsible for hematopoietic reconstitution are CD34+.
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Cited by
Circulating Fibrocytes Define a New Leukocyte Subpopulation That Mediates Tissue Repair
Bucala, R., Spiegel, L. A., Chesney, J., Hogan, M., & Cerami, A. (1994) · Molecular Medicine · doi:10.1007/bf03403533 · Cited by 1,308
Single platform flow cytometric absolute CD34+ cell counts based on the ISHAGE guidelines
Keeney, M., Chin-Yee, I., Weir, K., Popma, J., Nayar, R., & Sutherland, D. R. (1998) · Cytometry · doi:10.1002/(sici)1097-0320(19980415)34:2<61::aid-cyto1>3.0.co;2-f · Cited by 501
ABC Transporters as Phenotypic Markers and Functional Regulators of Stem Cells
Bunting, K. D. (2002) · STEM CELLS · doi:10.1002/stem.200011 · Cited by 458
Small, D., Levenstein, M., Kim, E., Carow, C., Amin, S., Rockwell, P., Witte, L., Burrow, C., Ratajczak, M. Z., & Gewirtz, A. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.2.459 · Cited by 429
Simmons, P., Masinovsky, B., Longenecker, B., Berenson, R., Torok-Storb, B., & Gallatin, W. (1992) · Blood · doi:10.1182/blood.v80.2.388.388 · Cited by 422
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Metadata
- Authors
- Berenson, R. J., Andrews, R. G., Bensinger, W. I., Kalamasz, D., Knitter, G., Buckner, C. D., & Bernstein, I. D.
- Venue
- Journal of Clinical Investigation
- Published
- 1988-03-01
- Volume
- 81
- Issue
- 3
- Pages
- 951-955
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2042021736
- Cited by
- 574
- References
- 0
- FWCI
- 12.60
- Type
- journal article
- Language
- en
- Open access
- green
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- Berenson, R. J., Andrews, R. G., Bensinger, W. I., Kalamasz, D., Knitter, G., Buckner, C. D., & Bernstein, I. D. (1988). Antigen CD34+ marrow cells engraft lethally irradiated baboons. Journal of Clinical Investigation. https://doi.org/10.1172/jci113409
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