STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells.

Small, D; Levenstein, M; Kim, E; Carow, C; Amin, S; Rockwell, P; Witte, L; Burrow, C; Ratajczak, M Z; Gewirtz, A M

doi:10.1073/pnas.91.2.459

Cited by 431Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia ResearchPlatelet Disorders and Treatments

STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells.

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Small, D, Levenstein, M, Kim, E, Carow, C, Amin, S, Rockwell, P, Witte, L, Burrow, C +2 more·1994·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.91.2.459PMC PMC42968

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Abstract

We cloned the cDNA for stem cell tyrosine kinase 1 (STK-1), the human homolog of murine Flk-2/Flt-3, from a CD34+ hematopoietic stem cell-enriched library and investigated its expression in subsets of normal human bone marrow. The cDNA encodes a protein of 993 aa with 85% identity and 92% similarity to Flk-2/Flt-3. STK-1 is a member of the type III receptor tyrosine kinase family that includes KIT (steel factor receptor), FMS (colony-stimulating factor 1R), and platelet-derived growth factor receptor. STK-1 expression in human blood and marrow is restricted to CD34+ cells, a population greatly enriched for stem/progenitor cells. Anti-STK-1 antiserum recognizes polypeptides of 160 and 130 kDa in several STK-1-expressing cell lines and in 3T3 cells transfected with a STK-1 expression vector. Antisense oligonucleotides directed against STK-1 sequences inhibited hematopoietic colony formation, most strongly in long-term bone marrow cultures. These data suggest that STK-1 may function as a growth factor receptor on hematopoietic stem and/or progenitor cells.

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Authors: Small, D., Levenstein, M., Kim, E., Carow, C., Amin, S., Rockwell, P., Witte, L., Burrow, C., Ratajczak, M. Z., & Gewirtz, A. M.
Affiliations: Johns Hopkins University (US)
ORCID: Rockwell, P
Ratajczak, M Z
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1994-01-18
Volume: 91
Issue: 2
Pages: 459-463
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.91.2.459
PMC: PMC42968
OpenAlex: W2032235066
Cited by: 429
References: 40
Citations by year: 2026: 5 · 2025: 6 · 2024: 6 · 2023: 4 · 2022: 8 · 2021: 11 · 2020: 12 · 2019: 8 · 2018: 2 · 2017: 9 · 2016: 4 · 2015: 3 · 2014: 14 · 2013: 7 · 2012: 15
FWCI: 16.04
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ca054384-03, 5p01ca051083-05)
National Cancer Institute (CA-54384, CA-51083, CA36896)
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
Keywords: CD34+ cells, hematopoietic stem cells, hematopoietic progenitor cells, bone marrow, cDNA cloning, antisense oligonucleotides, hematopoietic colony formation, growth factor receptors, KIT, FMS, platelet-derived growth factor receptor
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Bone Marrow, Bone Marrow Cells, Cloning, Molecular, Hematopoiesis, Hematopoietic Stem Cells, Humans, Molecular Sequence Data, Protein-Tyrosine Kinases, Proto-Oncogene Proteins, Antigens, CD, Gene Expression, Sequence Homology, Amino Acid, DNA, Complementary, Antigens, CD34, Receptor Protein-Tyrosine Kinases, Mice, fms-Like Tyrosine Kinase 3

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STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells.

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