Cited by 169Metabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

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Role of glucose transporters in the cellular insulin resistance of type II non-insulin-dependent diabetes mellitus.

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Garvey, W T, Huecksteadt, T P, Matthaei, S, Olefsky, J M·1988·Journal of Clinical Investigation

DOI 10.1172/jci113485PMC PMC442586

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Abstract

To examine the role of glucose transport proteins in cellular insulin resistance, we studied subcutaneous adipocytes isolated from lean control, obese control (body mass index [BMI] 33.4 +/- 0.9), and untreated obese non-insulin-dependent diabetes mellitus (NIDDM) patients (BMI 35.2 +/- 2.1; fasting glucose 269 +/- 20 mg/dl). Glucose transporters were measured in plasma membrane (PM), low-density (LDM), and high-density (HDM) microsomal subfractions from basal and maximally insulin-stimulated cells using the cytochalasin B binding assay, and normalized per milligram of membrane protein. In all subgroups, insulin led to an increase in PM glucose transporters and a corresponding depletion of transporters in the LDM. Insulin recruited 20% fewer transporters to the PM in the obese subgroup when compared with lean controls, and this was associated with a decline in LDM transporters with enlarging cell size in the control subjects. In NIDDM, PM, and LDM, transporters were decreased 50% in both basal and stimulated cells when compared with obese controls having similar mean adipocyte size. Cellular depletion of glucose transporters was not the only cause of insulin resistance, because the decrease in rates of [14C]-D-glucose transport (basal and insulin-stimulated) was greater than could be explained by reduced numbers of PM transporters in both NIDDM and obesity. In HDM, the number of transporters was not influenced by insulin and was similar in all subgroups. We conclude that (a) in NIDDM and obesity, both reduced numbers and impaired activity of glucose transporters contribute to cellular insulin resistance, and (b) in NIDDM, more profound cellular insulin resistance is associated primarily with a further depletion of cellular transporters.

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance.
National Diabetes Data Group (1979) · Diabetes · doi:10.2337/diab.28.12.1039 · Cited by 4,909
Use of Polyethylene Glycol to Separate Free and Antibody-Bound Peptide Hormones in Radioimmunoassays†
Desbuquois, B., & Aurbach, G. D. (1971) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-33-5-732 · Cited by 1,295
Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane.
Cushman, S. W., & Wardzala, L. J. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85561-8 · Cited by 1,088
Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site.
Suzuki, K. T., & Kôno, T. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.5.2542 · Cited by 1,030
Methods for the determination of adipose cell size in man and animals
Hirsch, J., & Gallian, E. (1968) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43151-7 · Cited by 894
Potential mechanism of insulin action on glucose transport in the isolated rat diaphragm. Apparent translocation of intracellular transport units to the plasma membrane.
Wardzala, L. J., & Jeanrenaud, B. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68926-x · Cited by 839
Preparation and properties of plasma membrane and endoplasmic reticulum fragments from isolated rat fat cells
Avruch, J., & Wallach, D. F. H. (1971) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(71)90331-2 · Cited by 834
Mechanisms of insulin resistance in human obesity: evidence for receptor and postreceptor defects.
Kolterman, O. G., Insel, J., Saekow, M., & Olefsky, J. M. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109790 · Cited by 664
Self-citation
Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus.
Kolterman, O., Gray, R. S., Griffin, J., BURSTEIN, P. J., Insel, J. R., Scarlett, J. A., & Olefsky, J. M. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110350 · Cited by 628
Self-citation

Show all 42 references

Research works printed but not linked: 1

Foley, J. E. 1986. Measurement of in vitro glucose transport and metabolism in isolated human adipocytes. In Methods in Diabetes Research, Vol. II. W. L. Clarke, J. Larner, and S. L. Pohl, editors. John Wiley & Sons, Inc., New York. 211-232.

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Fukumoto, H., Kayano, T., Buse, J. B., Edwards, Y. H., Pilch, P. F., Bell, G. I., & Seino, S. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83106-4 · Cited by 474
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Self-citation
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Self-citation
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Self-citation
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Self-citation
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Self-citation
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Self-citation
Interleukin-6 in transcatheter arterial embolization for patients with hepatocellular carcinoma. Effects of serine protease inhibitor
Matsuda, Y., Kawata, S., Nagase, T., Maeda, Y., Yamasaki, E., Kiso, S., Ishiguro, H., & Matsuzawa, Y. (1994) · Cancer · doi:10.1002/1097-0142(19940101)73:1 · Cited by 28
The role of mitochondrial reactive oxygen species in insulin resistance
Ayer, A., Fazakerley, D. J., James, D. E., & Stocker, R. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.11.007 · Cited by 50
Insulin resistance induced by high glucose and high insulin precedes insulin receptor substrate 1 protein depletion in human adipocytes
Renström, F., Burén, J., Svensson, M. K. E., & Eriksson, J. W. (2007) · Metabolism · doi:10.1016/j.metabol.2006.09.012 · Cited by 46
Insulin resistance, impaired glucose tolerance and non-insulin-dependent diabetes, pathologic mechanisms and treatment: Current status and therapeutic possibilities
Turner, N. C., & Clapham, J. C. (1998) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8845-5_2 · Cited by 46
Insulin-stimulated glucose transport in muscle. Evidence for a protein-kinase-C-dependent component which is unaltered in insulin-resistant mice
Tanti, J., Rochet, N., Grémeaux, T., OBBERGHEN, E. V., & MARCHAND‐BRUSTEL, Y. L. (1989) · Biochemical Journal · doi:10.1042/bj2580141 · Cited by 46
Posttranslational Modifications of GLUT4 Affect Its Subcellular Localization and Translocation
Sadler, J. B. A., Bryant, N. J., Gould, G. W., & Welburn, C. R. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14059963 · Cited by 44
Polymorphisms at the GLUT1 (HepG2) and GLUT4 (muscle/adipocyte) glucose transporter genes and non-insulin-dependent diabetes mellitus (NIDDM)
Baroni, M. G., Oelbaum, R. S., Pozzilli, P., Stocks, J., Li, S., Fiore, V., & Galton, D. J. (1992) · Human Genetics · doi:10.1007/bf00219344 · Cited by 41
Calcium-Sensing Receptor Expression in Human Adipocytes
Cifuentes, M., Cecilia Albala, B., & Rojas, C. (2005) · Endocrinology · doi:10.1210/en.2004-1281 · Cited by 42
Determining the relationship between dietary carbohydrate intake and insulin resistance
McClenaghan, N. H. (2005) · Nutrition Research Reviews · doi:10.1079/nrr2005109 · Cited by 42
Effect of insulin on GLUT-4 mRNA and protein concentrations in skeletal muscle of patients with NIDDM and their first-degree relatives
Schalin-J�ntti, C., Yki-J�rvinen, H., Koranyi, L. I., Bourey, R. E., Lindstr�m, J., Nikula-Ijäs, P., Franssila-Kallunki, A., & Groop, L. (1994) · Diabetologia · doi:10.1007/bf00408478 · Cited by 38
Pathogenesis of non-insulin-dependent (type II) diabetes mellitus (NIDDM) – genetic predisposition and metabolic abnormalities
Jun, H., Bae, H. Y., Lee, B. R., Koh, K. S., Kim, Y., Lee, K. W., Kim, H., & Yoon, J. (1999) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(98)00071-4 · Cited by 40
Insulin resistance versus insulin secretion in the hypertension of obesity.
Istfan, N. W., PLAISTED, C. S., Bistrian, B. R., & Blackburn, G. L. (1992) · Hypertension · doi:10.1161/01.hyp.19.4.385 · Cited by 41
Subcellular distribution of GLUT 4 in the skeletal muscle of lean type 2 (non-insulin-dependent) diabetic patients in the basal state
Vogt, B., Mühlbacher, C., Carrascosa, J., Obermaier-Kusser, B., Seffer, E., Mushack, J., Pongratz, D. E., & Häring, H.-U. (1992) · Diabetologia · doi:10.1007/bf02342444 · Cited by 37
Effect of streptozotocin-induced diabetes on GLUT-4 phosphorylation in rat adipocytes.
Begum, N., & Draznin, B. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115988 · Cited by 38
The effects of insulin on the level and activity of the GLUT4 present in human adipose cells
Kozka, I. J., CLARK, A. E., Reckless, J. P. D., Cushman, S. W., Gould, G. W., & Holman, G. D. (1995) · Diabetologia · doi:10.1007/bf00401836 · Cited by 37
Abnormal glucose transport and GLUT1 cell-surface content in fibroblasts and skeletal muscle from NIDDM and obese subjects
Miele, C., Formisano, P., Condorelli, G., Caruso, M., Oriente, F., Andreozzi, F., Tocchetti, C. G., Riccardi, G., & Bèguinot, F. (1997) · Diabetologia · doi:10.1007/s001250050696 · Cited by 38
Stimulation of Glucose Transport by Thyroid Hormone in ARL 15 Cells: Increased Abundance of Glucose Transporter Protein and Messenger Ribonucleic Acid*
Weinstein, S. P., Watts, J., Graves, P. N., & Haber, R. S. (1990) · Endocrinology · doi:10.1210/endo-126-3-1421 · Cited by 36
Impaired Tethering and Fusion of GLUT4 Vesicles in Insulin-Resistant Human Adipose Cells
Lizunov, V. A., Lee, J.-P., Skarulis, M. C., Zimmerberg, J. J., Cushman, S. W., & Stenkula, K. G. (2013) · Diabetes · doi:10.2337/db12-1741 · Cited by 35
Effects of high glucose on caveolin-1 and insulin signaling in 3T3-L1 adipocytes
Palacios-Ortega, S., Varela-Guruceaga, M., Martínez, J. A., de Miguel, C., & Milagro, F. I. (2015) · Adipocyte · doi:10.1080/21623945.2015.1122856 · Cited by 35
Muscle group-specific regulation of GLUT 4 glucose transporters in control, diabetic, and insulin-treated diabetic rats
Hardin, D. S., Dominguez, J. H., & Garvey, W. T. (1993) · Metabolism · doi:10.1016/0026-0495(93)90130-g · Cited by 35
Self-citation
Insulin and β-adrenergic receptors mediate lipolytic and anti-lipolytic signalling that is not altered by type 2 diabetes in human adipocytes
Jönsson, C., Castor Batista, A. P., Kjølhede, P., & Strålfors, P. (2019) · Biochemical Journal · doi:10.1042/bcj20190594 · Cited by 34
Glucose and Insulin Regulate Insulin Sensitivity in Primary Cultured Adipocytes without Affecting Insulin Receptor Kinase Activity*
Lima, F. B., Thies, R. S., & Garvey, W. T. (1991) · Endocrinology · doi:10.1210/endo-128-5-2415 · Cited by 33
Self-citation
The Role of the Angiotensin System in Cardiac Glucose Homeostasis
Bernobich, E., Angelis, L. D., Lerín, C., & Bellini, G. (2002) · Drugs · doi:10.2165/00003495-200262090-00002 · Cited by 32
Phenylarsine oxide causes an insulin-dependent, GLUT4-specific degradation in rat adipocytes.
Jhun, B. H., Hah, J.-S., & Jung, C. Y. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54563-4 · Cited by 31
Percutaneous Adipose Tissue Biopsy by Mini‐Liposuction for Metabolic Studies
Bastard, J., Cuevas, J., Cohen, S., Jardel, C., & Hainque, B. (1994) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607194018005466 · Cited by 30
TNFα Disrupts Mitotic Clonal Expansion and Regulation of Retinoblastoma Proteins p130 and p107 during 3T3-L1 Adipocyte Differentiation
Lyle, R. E., Richon, V. M., & McGehee, R. E. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8773 · Cited by 29
Inhibition of FOXO1 transcription factor in primary human adipocytes mimics the insulin-resistant state of type 2 diabetes
Rajan, M. R., Nyman, E., Brännmark, C., Olofsson, C. S., & Strålfors, P. (2018) · Biochemical Journal · doi:10.1042/bcj20180144 · Cited by 28
Expression of Glucokinase in Skeletal Muscle: A New Approach to Counteract Diabetic Hyperglycemia
Otaegui, P. J., Ferré, T., Pujol, A., Riu, E., Jiménez, R. P., & Bosch, F. (2000) · Human Gene Therapy · doi:10.1089/10430340050083270 · Cited by 28

Authors: Garvey, W. T., Huecksteadt, T. P., Matthaei, S., & Olefsky, J. M.
Affiliations: University of California San Diego (US)
United States Department of Veterans Affairs (US)
ORCID: Garvey, W T
Olefsky, J M
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1988-05-01
Volume: 81
Issue: 5
Pages: 1528-1536
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci113485
PMC: PMC442586
OpenAlex: W2143122636
Cited by: 169
References: 42
Citations by year: 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 5 · 2014: 2 · 2013: 3
FWCI: 6.06
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Pfizer
Deutsche Forschungsgemeinschaft
National Institutes of Health (AM-33639, 2r01am033651-03)
National Center for Research Resources (RR00827)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: glucose transporters, insulin resistance, type 2 diabetes, adipocytes, obesity, insulin-stimulated glucose transport, plasma membrane, low density microsomes, adipocyte size
MeSH terms: Adipose Tissue, Adult, Blood Glucose, Cell Membrane, Diabetes Mellitus, Diabetes Mellitus, Type 2, Female, Humans, Insulin Resistance, Male, Microsomes, Monosaccharide Transport Proteins, Obesity

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Role of glucose transporters in the cellular insulin resistance of type II non-insulin-dependent diabetes mellitus.

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