The DOI matches its Crossref record; 178 of the 178 references it cites were found in a registry or an index.
INTRACELLULAR CALCIUM RELEASE AND CARDIAC DISEASE
Abstract
▪ Abstract Intracellular calcium release channels are present on sarcoplasmic and endoplasmic reticuli (SR, ER) of all cell types. There are two classes of these channels: ryanodine receptors (RyR) and inositol 1,4,5-trisphosphate receptors (IP 3 R). RyRs are required for excitation-contraction (EC) coupling in striated (cardiac and skeletal) muscles. RyRs are made up of macromolecular signaling complexes that contain large cytoplasmic domains, which serve as scaffolds for proteins that regulate the function of the channel. These regulatory proteins include calstabin1/calstabin2 (FKBP12/FKBP12.6), a 12/12.6 kDa subunit that stabilizes the closed state of the channel and prevents aberrant calcium leak from the SR. Kinases and phosphatases are targeted to RyR2 channels and modulate RyR2 function in response to extracellular signals. In the classic fight or flight stress response, phosphorylation of RyR channels by protein kinase A reduces the affinity for calstabin and activates the channels leading to increased SR calcium release. In heart failure, a cardiac insult causes a mismatch between blood supply and metabolic demands of organs. The chronically activated fight or flight response leads to leaky channels, altered calcium signaling, and contractile dysfunction and cardiac arrhythmias.
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1 retracted
Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels
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Lima, B., Forrester, M. T., Hess, D. T., & Stamler, J. S. (2010) · Circulation Research · doi:10.1161/circresaha.109.207381 · Cited by 490
In vivo delivery of CRISPR-Cas9 therapeutics: Progress and challenges
Behr, M., Zhou, J., Xu, B., & Zhang, H. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.05.020 · Cited by 210
PCB-95 Promotes Dendritic Growth via Ryanodine Receptor–Dependent Mechanisms
Wayman, G. A., Yang, D., Bose, D. D., Lesiak, A., Ledoux, V., Bruun, D., Pessah, I. N., & Lein, P. J. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104832 · Cited by 136
Stamou, M., Streifel, K. M., Goines, P. E., & Lein, P. J. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2012.12.001 · Cited by 128
Metadata
- Authors
- Wehrens, X. H. T., Lehnart, S. E., & Marks, A. R.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2005-03-17
- Volume
- 67
- Issue
- 1
- Pages
- 69-98
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2158197581
- Cited by
- 355
- References
- 178
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wehrens, X. H. T., Lehnart, S. E., & Marks, A. R. (2005). INTRACELLULAR CALCIUM RELEASE AND CARDIAC DISEASE. Annual Review of Physiology. https://doi.org/10.1146/annurev.physiol.67.040403.114521
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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