The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Overexpression of human low density lipoprotein receptors leads to accelerated catabolism of Lp(a) lipoprotein in transgenic mice.
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Studies of mice catabolism of exogenous human Lp(a) have yielded mixed results, with some demonstrating LDLR-dependent and some LDLR-independent clearance.
“Although mice do not produce endogenous Lp(a), studies of their catabolism of exogenous human Lp(a) have also yielded mixed results, with some demonstrating LDLR-dependent35,36 and some LDLR-independent25,32 clearance.”
From Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening (2025) · cites this paper as [35]
Multiple studies of LDLR in cells, animal models, and humans have provided inconsistent or conflicting results.
“Multiple studies of the LDL receptor (LDLR) in cells27-34, animal models25,32,35,36, and humans10,28,37-48 have provided inconsistent or conflicting results.”
From Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening (2025) · cites this paper as [35]
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cDNA sequence of human apolipoprotein(a) is homologous to plasminogen
McLean, J. W., Tomlinson, J. E., Kuang, W.-J., Eaton, D. L., Chen, E. Y., Fless, G. M., Scanu, A. M., & Lawn, R. M. (1987) · Nature · doi:10.1038/330132a0 · Cited by 1,886 · cited 2×
“Apo(a) is related structurally to plasminogen, a circulating serine protease that is activated during clot lysis (2, 3).”
BackgroundSelf-citationHofmann, S. L., Russell, D. W., Brown, M. S., Goldstein, J. L., & Hammer, R. E. (1988) · Science · doi:10.1126/science.3344433 · Cited by 117
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Research works printed but not linked: 5
- Utermann, G., F. Hoppichler, H. Dieplinger, M. Seed, G. Thompson, and E. Boerwinkle. 1989. Defects in the low density lipo- protein receptor gene affect lipoprotein (a) levels: multiplicative inter- action oftwo gene loci associated with premature atherosclerosis. Proc. NatL. Acad. Sci. USA. 86:4171-4174.
- Goldstein, J. L., S. E. Dana, and M. S. Brown. 1974. Esterifica- tion of low density lipoprotein cholesterol in human fibroblasts and its absence in homozygous familial hypercholesterolemia. Proc. Natl. Acad. Sci. USA. 7 1:4288-4292.
- Innerarity, T. L., K. H. Weisgraber, K. S. Arnold, R. W. Mah- ley, R. M. Krauss, G. L. Vega, and S. M. Grundy. 1987. Familial defective apolipoprotein B-100: Low density lipoproteins with abnor- mal receptor binding. Proc. Natl. Acad. Sci. USA. 84:6919-6923.
- Soria, L. F., E. H. Ludwig, H. R. G. Clarke, G. L. Vega, S. M. Grundy, and B. J. McCarthy. 1989. Association between a specific apolipoprotein B mutation and familial defective apolipoprotein B-100. Proc. Natl. Acad. Sci. USA. 86:587-591.
- Jackson, R. L. 1984. Lipoprotein lipase and hepatic lipase. In The Enzymes. P. D. Boyer, editor. Academic Press, New York. 141-181.
Cited by
Sorted by citations
Schaefer, E. J. (1994) · JAMA · doi:10.1001/jama.1994.03510370051031 · Cited by 487
Hepatic Lipoprotein Metabolism: Current and Future In Vitro Cell-Based Systems
Kiss, I., Neuwert, N., Oberle, R., Hengstschläger, M., Osmanagic-Myers, S., & Stangl, H. (2025) · Biomolecules · doi:10.3390/biom15070956 · Cited by 11
Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening
Khan, T. G., Bragazzi Cunha, J., Raut, C., Burroughs, M., Vyas, H. S., Leix, K., Goonewardena, S. N., Smrcka, A. V., Speliotes, E. K., & Emmer, B. T. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.119174 · Cited by 6
Metadata
- Authors
- Hofmann, S. L., Eaton, D. L., Brown, M. S., McConathy, W. J., Goldstein, J. L., & Hammer, R. E.
- Venue
- Journal of Clinical Investigation
- Published
- 1990-05-01
- Volume
- 85
- Issue
- 5
- Pages
- 1542-1547
- ISSN
- 0021-9738
- Cited by
- 151
- References
- 2
- Language
- en
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