cDNA sequence of human apolipoprotein(a) is homologous to plasminogen
Abstract
Lipoprotein(a) is an LDL-like lipoprotein whose concentration in plasma is correlated with atherosclerosis. The characteristic protein component of lipoprotein(a) is apolipoprotein(a) which is disulphide-linked to apolipoprotein B-100. Sequencing of cloned human apolipoprotein(a) complementary DNA shows that it is very similar to human plasminogen. It contains a serine protease domain and two types of plasminogen-like kringle domains, one of which is present in 37 copies.
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The human gene apo(a), involved in lipid transport, originated from a duplication of the plasminogen gene.
“An emblematic case is the human gene apo(a), involved in lipid transport, which originated from a duplication of the plasminogen gene [11].”
From Origin and Evolution of Genes in Eukaryotes: Mechanisms, Dynamics, and Functional Implications (2025) · cites this paper as [11]
The effect of CPAP on primary or secondary prevention of CVD has not been proven yet in recent RCTs.
“However, the effect of CPAP on primary or secondary prevention of CVD has not proven yet in recent RCTs219, 220).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [220]
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- Authors
- McLean, J. W., Tomlinson, J. E., Kuang, W.-J., Eaton, D. L., Chen, E. Y., Fless, G. M., Scanu, A. M., & Lawn, R. M.
- Affiliations
- Genentech (US)
- University of Chicago (US)
- ORCID
- Eaton, Dan L.
- Venue
- Nature
- Published
- 1987-11
- Volume
- 330
- Issue
- 6144
- Pages
- 132-137
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2036170644
- Cited by
- 1,886
- References
- 1
- Citations by year
- 2026: 32 · 2025: 37 · 2024: 36 · 2023: 45 · 2022: 33 · 2021: 22 · 2020: 21 · 2019: 22 · 2018: 17 · 2017: 17 · 2016: 30 · 2015: 42 · 2014: 25 · 2013: 33 · 2012: 31
- FWCI
- 94.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- apolipoprotein(a), plasminogen, lipoprotein(a), cDNA sequence, sequence homology, serine protease domain, kringle domains, apolipoprotein B-100, atherosclerosis
- MeSH terms
- Amino Acid Sequence, Apolipoproteins A, Base Sequence, DNA, Biological Evolution, Humans, Molecular Sequence Data, Plasminogen, Protein Conformation, Sequence Homology, Nucleic Acid
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