The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
The acute splanchnic and peripheral tissue metabolic response to endotoxin in humans.
Open accessAbstract
The in vivo alterations in organ-specific substrate processing and endogenous mediator production induced by endotoxin were investigated in healthy volunteers. An endotoxin bolus (20 U/kg) produced increased energy expenditure, hyperglycemia, hypoaminoacidemia, and an increase in circulating free fatty acids. These changes included increased peripheral lactate and free fatty acid output, along with increased peripheral uptake of glucose. Coordinately, there were increased splanchnic uptake of oxygen, lactate, amino acids, and free fatty acids, and increased splanchnic glucose output. There were no changes in circulating glucagon, or insulin and transient changes in epinephrine and cortisol were insufficient to explain the metabolic changes. Plasma cachectin levels peaked 90 min after the endotoxin infusion, and hepatic venous (HV) cachectin levels (peak 250 +/- 50 pg/ml) were consistently higher than arterial levels (peak 130 +/- 30 pg/ml, P less than 0.05 vs. HV). No interleukin 1 alpha or 1 beta was detected in the circulation. Circulating interleukin 6, measured by B.9 hybridoma proliferation, peaked 2 h after the endotoxin challenge (arterial, 16 +/- 2 U/ml; HV, 21 +/- 3 U/ml). The net cachectin efflux (approximately 7 micrograms) from the splanchnic organs demonstrates that these tissues are a major site for production of this cytokine. Hence, splanchnic tissues are likely influenced in a paracrine fashion by regional cachectin production and may also serve as a significant source for systemic appearance of this cytokine.
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Citations
Cites
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“Furthermore, administration of antibodies specific for cachectin prevented cardiovascular collapse and death in rabbits receiving endotoxin (17), and in primates receiving an otherwise lethal dose of Escherichia coli (18).”
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Cited by
A network-based analysis of systemic inflammation in humans
Program, I. A. H. R. T. I. L. S. C. R., Calvano, S. E., Xiao, W., Richards, D. R., Felciano, R. M., Baker, H. V., Cho, R. J., Chen, R. O., Brownstein, B. H., Cobb, J. P., et al. (2005) · Nature · doi:10.1038/nature03985 · Cited by 1,429
Self-citationVan Zee, K. J., Kohno, T., Fischer, E., Rock, C. S., Moldawer, L. L., & Lowry, S. F. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.11.4845 · Cited by 845
Self-citationHyperdynamic circulation in cirrhosis: A role for nitric oxide?
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Rock, C. S., & Lowry, S. F. (1991) · Journal of Surgical Research · doi:10.1016/0022-4804(91)90146-d · Cited by 503
Self-citationGlucose metabolism and catecholamines
Barth, E., Albuszies, G., Baumgart, K., Matejovic, M., Wachter, U., Vogt, J., Radermacher, P., & Calzia, E. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000278047.06965.20 · Cited by 384
Metadata
- Authors
- Fong, Y. M., Marano, M. A., Moldawer, L. L., Wei, H., Calvano, S. E., Kenney, J. S., Allison, A. C., Cerami, A., Shires, G. T., & Lowry, S. F.
- Venue
- Journal of Clinical Investigation
- Published
- 1990-06-01
- Volume
- 85
- Issue
- 6
- Pages
- 1896-1904
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2067121530
- Cited by
- 364
- References
- 61
- FWCI
- 19.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fong, Y. M., Marano, M. A., Moldawer, L. L., Wei, H., Calvano, S. E., Kenney, J. S., Allison, A. C., Cerami, A., Shires, G. T., & Lowry, S. F. (1990). The acute splanchnic and peripheral tissue metabolic response to endotoxin in humans. Journal of Clinical Investigation. https://doi.org/10.1172/jci114651
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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