Whole-body lipolysis and triglyceride-fatty acid cycling in cachectic patients with esophageal cancer.
Open accessAbstract
Whole-body lipolytic rates and the rate of triglyceride-fatty acid cycling (reesterification of fatty acids released during lipolysis) were measured with stable isotopic tracers in the basal state and during beta-adrenergic blockade with propranolol infusion in five cachectic patients with squamous cell carcinoma of the esophagus, five cachectic cancer-free, nutritionally-matched control patients, and 10 healthy volunteers. Resting energy expenditure and plasma catecholamines were normal in all three groups. The basal rate of glycerol appearance in blood in the patients with cancer (2.96 +/- 0.45 mumol.kg-1.min-1) was similar to that in the nutritionally matched controls (3.07 +/- 0.28 mumol.kg-1.min-1), but 48% greater than in the normal-weight volunteers (2.00 +/- 0.16 mumol.kg-1.min-1) (P = 0.028). The antilipolytic effect of propranolol and the rate of triglyceride-fatty acid cycling in the patients with cancer were also similar in the cachectic control group and approximately 50% greater than in the normal-weight volunteers, but the differences were not statistically significant because of the variability in the data. We conclude that the increase in lipolysis and triglyceride-fatty acid cycling in "unstressed" cachectic patients with esophageal cancer is due to alterations in their nutritional status rather than the presence of tumor itself. Increased beta-adrenergic activity may be an important contributor to the stimulation of lipolysis.
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Triglyceride/fatty acid cycling is involved in the thermogenesis associated with burn injuries, cancer cachexia, and after exercise.
“This cycling is involved in the thermogenesis associated with burn injuries 26, cancer cachexia 27, and after exercise 28.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [27]
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Self-citation
- Authors
- Klein, S., & Wolfe, R. R.
- Affiliations
- The University of Texas Medical Branch at Galveston (US)
- Shriners Hospitals for Children - Galveston (US)
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 1990-11-01
- Volume
- 86
- Issue
- 5
- Pages
- 1403-1408
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC296882
- OpenAlex
- W2015843414
- Cited by
- 82
- References
- 45
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 3
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Institute for Cancer Research
- American Gastroenterological Association
- National Institutes of Health (5r29ca050330-05, RR-00073)
- National Cancer Institute (CA 50330)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-38010, R01DK038010)
- National Center for Research Resources (RR 00073, M01RR000073)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- fatty acid re-esterification, cancer cachexia, esophageal squamous cell carcinoma, propranolol, beta-adrenergic blockade, beta-adrenergic activity, nutritional status
- MeSH terms
- Adult, Aged, Cachexia, Carcinoma, Squamous Cell, Esophageal Neoplasms, Fatty Acids, Female, Glycerol, Humans, Lipolysis, Male, Middle Aged, Propranolol, Triglycerides
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