The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Production of transforming growth factor beta 1 during repair of arterial injury.
Open accessAbstract
Repair of arterial injury produced by balloon angioplasty leads to the formation of a neointima and a narrowing of the vascular lumen. In this study, we examined the possibility that smooth muscle cells (SMC) in injured rat carotid arteries are stimulated to produce type-1 transforming growth factor-beta (TGF-beta 1) during neointima formation in vivo. Levels of TGF-beta 1 transcripts (2.4 kb) were significantly increased within 6 h after carotid injury and reached a maximum (five to sevenfold) by 24 h. Regenerating left carotids had sustained increases in TGF-beta 1 mRNA levels (about fivefold) over the next 2 wk, during which time a substantial neointimal thickening was formed. No changes in basal TGF-beta 1 mRNA levels were found in contralateral uninjured carotids at any of the times examined. Immunohistochemical studies showed that a large majority of neointimal SMC were stained for TGF-beta 1 protein in an intracellular pattern, consistent with active TGF-beta 1 synthesis in this tissue. Neointima formation and TGF-beta 1 immunoreactivity were correlated with increases in fibronectin, collagen alpha 2(I), and collagen alpha 1(III) gene expression. Infusion of purified, recombinant TGF-beta 1 into rats with a preexisting neointima produced a significant stimulation of carotid neointimal SMC DNA synthesis. These results suggest that TGF-beta 1 plays an important role as an endogenous growth regulatory factor produced by neointimal SMC themselves during progressive neointimal thickening after balloon angioplasty.
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Cites
Ignotz, R. A., & Massagué, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35666-1 · Cited by 2,492
Cited by
Yan, S. F., Ramasamy, R., Naka, Y., & Schmidt, A. M. (2003) · Circulation Research · doi:10.1161/01.res.0000103862.26506.3d · Cited by 513
McNamara, C. A., Sarembock, I. J., Gimple, L. W., Fenton, J. W., Coughlin, S. R., & Owens, G. K. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116206 · Cited by 499
Age-associated Cardiovascular Changes in Health: Impact on Cardiovascular Disease in Older Persons
Lakatta, E. G. (2002) · Heart Failure Reviews · doi:10.1023/a:1013797722156 · Cited by 445
Inhibition of the mTORC Pathway in the Antiphospholipid Syndrome
Canaud, G., Bienaimé, F., Tabarin, F., Bataillon, G., Seilhean, D., Noël, L.-H., Dragon-Durey, M.-A., Snanoudj, R., Friedlander, G., Halbwachs-Mecarelli, L., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1312890 · Cited by 355
Antibodies against transforming growth factor-beta 1 suppress intimal hyperplasia in a rat model.
Wolf, Y. G., Rasmussen, L. M., & Ruoslahti, E. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117070 · Cited by 304
Metadata
- Authors
- Majesky, M. W., Lindner, V, Twardzik, D. R., Schwartz, S. M., & Reidy, M. A.
- Venue
- Journal of Clinical Investigation
- Published
- 1991-09-01
- Volume
- 88
- Issue
- 3
- Pages
- 904-910
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2129963242
- Cited by
- 525
- References
- 1
- FWCI
- 10.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Majesky, M. W., Lindner, V, Twardzik, D. R., Schwartz, S. M., & Reidy, M. A. (1991). Production of transforming growth factor beta 1 during repair of arterial injury. Journal of Clinical Investigation. https://doi.org/10.1172/jci115393
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
