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The plasminogen activator/plasmin system.
Open accessAbstract
proteases and inhibitors has been shown to be under the control of hormones and growth factors. Plasminogen activators (PAs) and their inhibitors (PAIs) are thought to be key participants in the balance ofproteolytic and antiproteolytic activities that regulates matrix turnover. This article summarizes the evidence that supports this contention, discusses the role ofPAspecific cell surface binding sites, and also draws attention to a number of instances in which the presence ofPAs cannot be reconciled with an exclusive function in ECM degradation.
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Citations
Cited by
MCGEER, P., & MCGEER, E. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(95)00011-9 · Cited by 1,287
Impaired wound healing in mice with a disrupted plasminogen gene
Rømer, J., Bugge, T. H., Fyke, C., Lund, L. R., Flick, M. J., Degen, J. L., & Danø, K. (1996) · Nature Medicine · doi:10.1038/nm0396-287 · Cited by 561
Deng, G., Curriden, S. A., Wang, S., Rosenberg, S., & Loskutoff, D. J. (1996) · The Journal of cell biology · doi:10.1083/jcb.134.6.1563 · Cited by 448
Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.
Bugge, T. H., Flick, M. J., Daugherty, C. C., & Degen, J. L. (1995) · Genes & Development · doi:10.1101/gad.9.7.794 · Cited by 438
Sivasubramanian, N., Coker, M. L., Kurrelmeyer, K. M., MacLellan, W. R., DeMayo, F. J., Spinale, F. G., & Mann, D. L. (2001) · Circulation · doi:10.1161/hc3401.093154 · Cited by 382
Metadata
- Authors
- Vassalli, J. D., Sappino, A. P., & Belin, D.
- Venue
- Journal of Clinical Investigation
- Published
- 1991-10-01
- Volume
- 88
- Issue
- 4
- Pages
- 1067-1072
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2107908226
- Cited by
- 1,164
- References
- 0
- FWCI
- 22.74
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vassalli, J. D., Sappino, A. P., & Belin, D. (1991). The plasminogen activator/plasmin system. Journal of Clinical Investigation. https://doi.org/10.1172/jci115405
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
