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Cited by 450

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Inactivation of endothelial derived relaxing factor by oxidized lipoproteins.

Open access
Chin, J H, Azhar, S, Hoffman, B B·1992·Journal of Clinical Investigation
DOI 10.1172/jci115549
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Abstract

Endothelial cell derived relaxing factor (EDRF) mediated relaxation of blood vessels is impaired in vessels exposed to lipoproteins in vitro and in arteries of hyperlipidemic humans and animals. To investigate the mechanism by which lipoproteins impair the effects of EDRF, which is likely nitric oxide (NO) or a related molecule, we have bioassayed EDRF/NO activity by measuring its ability to increase cGMP accumulation in rat fetal lung cultured fibroblasts (RFL-6 cells). Low density lipoprotein modified by oxidation (ox-LDL) induced a concentration-dependent inhibition of EDRF activity that had been released from bovine aortic endothelial cells (BAEC) stimulated with bradykinin or the calcium ionophore A23187. In addition, lipoproteins directly impaired authentic NO-induced stimulation of cGMP accumulation in the detector cells; stimulation by sodium nitroprusside was unaffected. Ox-LDL or oxidized HDL3 were highly potent in blocking NO-stimulated cGMP accumulation with EC50's of approximately 1 microgram/ml. Lipid extracted from ox-LDL blocked NO-stimulated cGMP accumulation to about the same extent as intact ox-LDL, while the protein component of ox-LDL did not inhibit the cGMP response. These results suggest that the lipid component of oxidized lipoproteins inactivate EDRF after its release from endothelial cells.

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Metadata

Authors
Chin, J. H., Azhar, S., & Hoffman, B. B.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1992-01-01
Volume
89
Issue
1
Pages
10-18
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci115549
OpenAlex
W2030747750
Cited by
450
References
38
FWCI
14.62
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Inactivation of endothelial derived relaxing factor by oxidized lipoproteins. https://app.cochat.ai/papers/10.1172/jci115549
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Chin, J. H., Azhar, S., & Hoffman, B. B. (1992). Inactivation of endothelial derived relaxing factor by oxidized lipoproteins. Journal of Clinical Investigation. https://doi.org/10.1172/jci115549

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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