Cited by 400Sexual Differentiation and DisordersAdrenal Hormones and DisordersHormonal and reproductive studies

The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.

Genetic and pharmacological evidence for more than one human steroid 5 alpha-reductase.

Open access

Jenkins, E P, Andersson, S, Imperato-McGinley, J, Wilson, J D, Russell, D W·1992·Journal of Clinical Investigation

Open this paper in CoChat — free account Open PDF

Abstract

The enzyme steroid 5 alpha-reductase catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone, and impairment of this reaction causes a form of male pseudohermaphroditism in which genetic males differentiate predominantly as phenotypic females. We previously isolated cDNA clones that encode a human steroid 5 alpha-reductase enzyme. Here, we report molecular and genetic studies demonstrating that the gene encoding this cDNA is normal in subjects with the genetic disease steroid 5 alpha-reductase deficiency. We further show that in contrast to the major steroid 5 alpha-reductase in the prostate and cultured skin fibroblasts, the cDNA-encoded enzyme exhibits a neutral to basic pH optima and is much less sensitive to inhibition by the 4-aza steroid, finasteride (MK-906). The results provide genetic, biochemical, and pharmacological support for the existence of at least two steroid 5 alpha-reductase isozymes in man.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci115574

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Molecular cloning: A laboratory manual
Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684
DNA sequencing with chain-terminating inhibitors
Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719
[57] Sequencing end-labeled DNA with base-specific chemical cleavages
Maxam, A. M., & Gilbert, W. (1980) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(80)65059-9 · Cited by 13,943
[2] New M13 vectors for cloning
Messing, J. W. (1983) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(83)01005-8 · Cited by 5,240
SPLICING OF MESSENGER RNA PRECURSORS
Padgett, R. A., Grabowski, P. J., Konarska, M. M., Seiler, S., & Sharp, P. A. (1986) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.55.070186.005351 · Cited by 1,224
Splicing of Messenger RNA Precursors
Sharp, P. A. (1987) · Science · doi:10.1126/science.3544217 · Cited by 895
Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases
Andersson, S., & Russell, D. W. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.10.3640 · Cited by 501
Self-citation
Mutation in LDL Receptor: Alu-Alu Recombination Deletes Exons Encoding Transmembrane and Cytoplasmic Domains
Lehrman, M. A., Schneider, W. J., Südhof, T. C., Brown, M. S., Goldstein, J. L., & Russell, D. W. (1985) · Science · doi:10.1126/science.3155573 · Cited by 456
Self-citation
Male pseudohermaphroditism due to steroid 5α-reductase deficiency
Peterson, R. E., Imperato‐McGinley, J., Gautier, T., & Sturla, E. (1977) · The American Journal of Medicine · doi:10.1016/0002-9343(77)90313-8 · Cited by 392
Self-citation

Flagged first, then by citations

Show all 32 references

1 of the 32 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

Griffin, J. E., and J. D. Wilson. 1989. The androgen resistance syndromes: 5a-reductase deficiency, testicular feminization, and related disorders. In The Metabolic Basis of Inherited Disease. C. R. Scriver, A. L. Beaudet, W. S. Sly, and D. Valle, editors. McGraw-Hill Inc., New York. 1919-1944.
Andersson, S., and D. W. Russell. 1990. Structural and biochemical prop- erties of cloned and expressed human and rat steroid Sa-reductases. Proc. Nadt. Acad. Sci. USA. 87:3640-3644.
Segel, I. H. 1975. Behavior and analysis of rapid equilibrium and steady- state enzyme systems. In Enzyme Kinetics. Wiley & Sons, New York. 1-957.

Sorted by citations

Items 101–200 of 400

Inhibition of Human Steroid 5β-Reductase (AKR1D1) by Finasteride and Structure of the Enzyme-Inhibitor Complex
Drury, J. E., Costanzo, L. D., Penning, T. M., & Christianson, D. W. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.c109.016931 · Cited by 69
Benign prostatic hyperplasia: An overview of existing treatment
Dhingra, N., & Bhagwat, D. (2011) · Indian Journal of Pharmacology · doi:10.4103/0253-7613.75657 · Cited by 67
The Molecular Genetics of Steroid 5α-Reductases
Russell, D. W., Berman, D. M., BRYANT, J. T., Cala, K. M., Davis, D. L., Landrum, C. P., Prihoda, J. S., Silver, R. I., Thigpen, A. E., & Wigley, W. C. (1994) · Elsevier eBooks · doi:10.1016/b978-0-12-571149-4.50018-0 · Cited by 68
Self-citation
FK143, a novel nonsteroidal inhibitor of steroid 5α-reductase: (1) In vitro effects on human and animal prostatic enzymes
Hirosumi, J., Nakayama, O., Fagan, T., SAWADA, K., Chida, N., Inami, M., Takahashi, S., Kojo, H., Notsu, Y., & OKUHARA, M. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(94)00187-q · Cited by 61
Activity of 5-Alpha-Reductase and 17-Beta-Hydroxysteroid Dehydrogenase in the Infrainfundibulum of Subjects with and without Acne vulgaris
Thiboutot, D. M., Knaggs, H. E., Gilliland, K., & Lin, G. (1998) · Dermatology · doi:10.1159/000017863 · Cited by 63
Molecular analysis of 5α‐reductase type 2 gene in eight unrelated egyptian children with suspected 5α‐reductase deficiency: prevalence of the G34R mutation
Mazen, I., Gad, Y. Z., Hafez, M. M., Sultan, C., & Lumbroso, S. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01763.x · Cited by 63
LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1.
Hirsch, K. S., Jones, C. D., Audia, J. E., Andersson, S., McQuaid, L. A., Stamm, N. B., Neubauer, B. L., Pennington, P., Toomey, R. E., & Russell, D. W. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.11.5277 · Cited by 62
Self-citation
5 alpha-reductase-2 gene mutations in the Dominican Republic
Cai, L., Zhu, Y., Katz, M. D., Herrera, C., Baez, J. M., Ricart, M. D., Shackleton, C. H. L., & Imperato‐McGinley, J. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.5.1730 · Cited by 62
Self-citation
Association of Benign Prostatic Hyperplasia with Male Pattern Baldness
Oh, B. R., Kim, S., Moon, J. D., Kim, H. N., Kwon, D. D., Won, Y. H., Ryu, S. B., & Park, Y. I. (1998) · Urology · doi:10.1016/s0090-4295(98)00108-3 · Cited by 62
A polymorphism of the 5 alpha-reductase gene and its association with prostate cancer: a case-control analysis.
Kantoff, P. W., Febbo, P. G., Giovannucci, E. L., Krithivas, K., Dahl, D. M., Chang, G. T. G., Hennekens, C. H., Brown, M., & Stampfer, M. J. (1997) · PubMed · Cited by 61
Androgen Metabolism in Men Receiving Finasteride before Prostatectomy
Norman, R. W., Coakes, K. E., Wright, A. S., & Rittmaster, R. S. (1993) · The Journal of Urology · doi:10.1016/s0022-5347(17)35882-2 · Cited by 60
Disorders of Hair
Messenger, A. G., BERKER, D. A. R., & Sinclair, R. D. (2010) · Wiley eBooks · doi:10.1002/9781444317633.ch66 · Cited by 62
Finasteride: the first 5 alpha-reductase inhibitor.
Sudduth, S. L., & Koronkowski, M. (1993) · PubMed · Cited by 60
Natural potent androgens: Lessons from human genetic models
Zhu, Y., Katz, M. D., & Imperato‐McGinley, J. (1998) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(98)80478-3 · Cited by 60
Self-citation
Effects of the 5α-Reductase Inhibitor Finasteride on Serum Levels of Gonadal, Adrenal, and Hypophyseal Hormones and its Clinical Significance: A Prospective Clinical Study
Uygur, M. C., Arık, A. İ., Altuğ, U., & Erol, D. (1998) · Steroids · doi:10.1016/s0039-128x(98)00005-1 · Cited by 60
Molecular genetic analysis and human chorionic gonadotropin stimulation tests in the diagnosis of prepubertal patients with partial 5α-reductase deficiency
Hiort, O., Willenbring, H., Albers, N., Hecker, W., Engert, J., DIBBELT, L., & Sinnecker, G. H. G. (1996) · European Journal of Pediatrics · doi:10.1007/bf01955179 · Cited by 60
Human Osteoblast-Like Cells Express Predominantly Steroid 5α-Reductase Type 1
Issa, S., Schnabel, D., Feix, M., Wolf, L., Schaefer, H.-E., Russell, D. W., & Schweikert, H. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2001-011902 · Cited by 58
Self-citation
Evaluation and Nonsurgical Management of Benign Prostatic Hyperplasia
McNicholas, T., Kirby, R. S., & Lepor, H. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4160-6911-9.00092-x · Cited by 58
5α-Reductases in human physiology: an unfolding story
Traish, A. M. (2012) · Endocrine Practice · doi:10.4158/ep12108.ra · Cited by 57
Hormones and acne: Pathophysiology, clinical evaluation, and therapies
Thiboutot, D. M. (2001) · Seminars in Cutaneous Medicine and Surgery · doi:10.1053/sder.2001.28208 · Cited by 57
Epristeride is a selective and specific uncompetitive inhibitor of human steroid 5α-reductase isoform 2
Levy, M. A., Brandt, M. A., Sheedy, K. M., Dinh, J. T., Holt, D. A., Garrison, L. M., Bergsma, D. J., & Metcalf, B. W. (1994) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(94)90145-7 · Cited by 54
Androgen Conjugates: Physiology and Clinical Significance
Rittmaster, R. S. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-1-121 · Cited by 56
Molecular study of the 5 alpha-reductase type 2 gene in three European families with 5 alpha-reductase deficiency
Boudon, C., Lumbroso, S., Lobaccaro, J. M., Szarras‐Czapnik, M., Romer, T. E., Garandeau, P., Montoya, P., & Sultan, C. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.80.7.2149 · Cited by 57
Testosterone metabolism in primary cultures of human prostate epithelial cells and fibroblasts
́los, S. D., Carsol, J.-L., Ghazarossian, E., Raynaud, J., & Martin, P. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00184-0 · Cited by 55
Finasteride in the treatment of hirsutism: new therapeutic perspectives
Tolino, A., Petrone, A., Sarnacchiaro, F., Cirillo, D., Ronsini, S., Lombardi, G., & Nappi, C. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58388-5 · Cited by 54
A comparison between spironolactone and spironolactone plus finasteride in the treatment of hirsutism
Keleştimur, F., Everest, H., Unluhizarci, K., Bayram, F., & Sahin, Y. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1500351 · Cited by 53
A Systemic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia: A Review
Ashique, S., Sandhu, N. K., Haque, S. N., & Koley, K. (2020) · Natural Products and Bioprospecting · doi:10.1007/s13659-020-00267-9 · Cited by 51
Uniparental Disomy in Steroid 5 -Reductase 2 Deficiency
Chávez, B. A., Valdez, E., & Vilchis, F. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6786 · Cited by 53
Characterization of the 5 -Reductase-3 -Hydroxysteroid Dehydrogenase Complex in the Human Brain
Steckelbroeck, S., Watzka, M., Reichelt, R., Hans, V., Stoffel‐Wagner, B., Heidrich, D. D., Schramm, J., BIDLINGMAIER, F., & Klingmüller, D. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7325 · Cited by 56
Male pattern baldness: current treatments, future prospects
Ellis, J. A., & Sinclair, R. D. (2008) · Drug Discovery Today · doi:10.1016/j.drudis.2008.05.010 · Cited by 49
Potential activities of androgen metabolizing enzymes in human prostate
Krieg, M., Weißer, H., & Tunn, S. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00085-e · Cited by 49
Aromatization Mediates Testosterone's Short-Term Feedback Restraint of 24-Hour Endogenously Driven and Acute Exogenous Gonadotropin-Releasing Hormone-Stimulated Luteinizing Hormone and Follicle-Stimulating Hormone Secretion in Young Men
Schnorr, J. A., Bray, M. J., & Veldhuis, J. D. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.6.7520 · Cited by 55
Immunolocalization of 5α-Reductase Isozymes in Acne Lesions and Normal Skin
Thiboutot, D. M., Bayne, E. K., Thorne, J. E., Gilliland, K., Flanagan, J., Shao, Q., Light, J., & Helm, K. F. (2000) · Archives of Dermatology · doi:10.1001/archderm.136.9.1125 · Cited by 48
[Phase III study].
Furuse, K. (1995) · PubMed · Cited by 48
17.beta.-(N-tert-Butylcarbamoyl)-4-aza-5.alpha.-androstan-1-en-3-one Is an Active Site-Directed Slow Time-Dependent Inhibitor of Human Steroid 5.alpha.-Reductase 1
Tian, G., Stuart, J. D., Moss, M. L., Domanico, P. L., Bramson, H. N., Patel, I. R., Kadwell, S. H., Overton, L. K., & Kost, T. A. (1994) · Biochemistry · doi:10.1021/bi00174a041 · Cited by 47
Treatment of hirsutism by finasteride and flutamide in women with polycystic ovary syndrome
Falsetti, L., Fusco, D. D., Eleftheriou, G., & Rosina, B. (1997) · Gynecological Endocrinology · doi:10.3109/09513599709152542 · Cited by 47
Isoenzyme type 1 of 5alpha-reductase is abundantly transcribed in normal human genital skin fibroblasts and may play an important role in masculinization of 5alpha-reductase type 2 deficient males
Thiele, S., Hoppe, U., Holterhus, P., & Hiort, O. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01927 · Cited by 46
Molecular Characterization of 6 Unrelated Italian Patients With 5α‐Reductase Type 2 Deficiency
Baldinotti, F., Majore, S., Fogli, A., Marrocco, G., Ghirri, P., Vuerich, M., Tumini, S., Boscherini, B., Vetri, M. G., Scommegna, S., et al. (2007) · Journal of Andrology · doi:10.2164/jandrol.107.002592 · Cited by 46
19-Nor-10-azasteroids: A Novel Class of Inhibitors for Human Steroid 5α-Reductases 1 and 2
Guarna, A., Belle, C., Machetti, F., Occhiato, E. G., Payne, A. H., Cassiani, C., Comerci, A., Danza, G., Bellis, A. D., Dini, S., et al. (1997) · Journal of Medicinal Chemistry · doi:10.1021/jm960807v · Cited by 46
The localisation and expression of 5 alpha-reductase types I and II mRNAs in human hyperplastic prostate and in prostate primary cultures
Habib, F. K., Ross, M., Bayne, C. W., Grigor, K. M., Buck, A. C., Bollina, P. R., & Chapman, K. E. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1560509 · Cited by 46
Comparison of the effects of new specific azasteroid inhibitors of steroid 5α‐reductase on canine hyperplastic prostate: Suppression of prostatic DHT correlated with prostate regression
Cohen, S. M., Werrmann, J. G., Rasmusson, G. H., Tanaka, W. K., Malatesta, P. F., Harris, G., Prahalada, S., Jacobs, J. G., & Nett, T. M. (1995) · The Prostate · doi:10.1002/pros.2990260202 · Cited by 45
The Molecular Basis of 5α-Reductase Type 2 Deficiency
Batista, R. L., & Mendonca, B. B. (2022) · Sexual Development · doi:10.1159/000525119 · Cited by 47
PNU 157706, a novel dual type I and II5α-reductase inhibitor
di Salle, E., Giudici, D., Radice, A., Zaccheo, T., Ornati, G., Nesi, M., Panzeri, A., Délos, S., & Martin, P. (1998) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(97)00158-1 · Cited by 43
Differential regulation of rat testicular 5alpha-reductase type 1 and 2 isoforms by testosterone and FSH
PRATIS, K., O’Donnell, L., Ooi, G. T., Stanton, P. G., McLachlan, R., & Robertson, D. (2003) · Journal of Endocrinology · doi:10.1677/joe.0.1760393 · Cited by 43
Effects of chromosomal sex and hormonal influences on shaping sex differences in brain and behavior: Lessons from cases of disorders of sex development
Bramble, M. S., Lipson, A., Vashist, N., & Vilain, E. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23832 · Cited by 42
Genetic Diseases of Steroid Metabolism
White, P. C. (1994) · Vitamins and hormones · doi:10.1016/s0083-6729(08)61147-4 · Cited by 43
Inhibition of Human Steroid 5α Reductases type I and II by 6-Aza-Steroids: Structural Determinants of One-Step vs Two-Step Mechanism
Moss, M. L., Kuzmič, P., Stuart, J. D., Tian, G., Peranteau, A. G., Frye, S. V., Kadwell, S. H., Kost, T. A., Overton, L. K., & Patel, I. R. (1996) · Biochemistry · doi:10.1021/bi952472+ · Cited by 42
BENIGN PROSTATIC HYPERPLASIA
McConnell, J. D. (1995) · Urologic Clinics of North America · doi:10.1016/s0094-0143(21)00674-1 · Cited by 41
The Basic Science of Hair Biology
Breitkopf, T., Leung, G., Yu, M., Wang, E., & McElwee, K. J. (2012) · Dermatologic Clinics · doi:10.1016/j.det.2012.08.006 · Cited by 40
A new deletion of the 5α‐reductase type 2 gene in a Turkish family with 5α‐reductase deficiency
Boudon, C., Lobaccaro, J. A., Lumbroso, S., Ösgur, G., Öçal, G., Belon, C., & Sultan, C. (1995) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1995.tb01913.x · Cited by 40
Male hormonal contraception: concept proven, product in sight?
Matthiesson, K. L., & McLachlan, R. I. (2006) · Human Reproduction Update · doi:10.1093/humupd/dml010 · Cited by 40
Male androgenetic alopecia
Sinclair, R. D. (2004) · The Journal of Men s Health and Gender · doi:10.1016/j.jmhg.2004.09.016 · Cited by 39
5α-Reductase inhibition by finasteride (proscar®) in epithelium and stroma of human benign prostatic hyperplasia
Weißer, H., Tunn, S., Debus, M., & Krieg, M. (1994) · Steroids · doi:10.1016/0039-128x(94)90016-7 · Cited by 38
Messenger Ribonucleic Acid Levels of Steroid 5 -Reductase 2 in Human Prostate Predict the Enzyme Activity
Söderström, T. G., Bjelfman, C., Brekkan, E., Ask, B., Egevad, L., Norlén, B. J., & Rane, A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7224 · Cited by 37
MK-386, an Inhibitor of 5α-Reductase Type 1, Reduces Dihydrotestosterone Concentrations in Serum and Sebum without Affecting Dihydrotestosterone Concentrations in Semen1
Schwartz, J. I., Tanaka, W. K., Wang, D. Z., Ebel, D. L., Geissler, L. A., Dallob, A. L., Hafkin, B., & Gertz, B. J. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.5.3912 · Cited by 37
Nonisotopic single strand conformation analysis of the 5 alpha- reductase type 2 gene for the diagnosis of 5 alpha-reductase deficiency
Hiort, O., Sinnecker, G. H. G., Willenbring, H., Lehners, A., Zollner, A. N., & Struve, D. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.9.3415 · Cited by 36
The mRNAs for the Steroid 5α‐Reductase Isozymes, Types 1 and 2, Are Differentially Regulated in the Rat Epididymis
Viger, R. S., & Robaire, B. (1996) · Journal of Andrology · doi:10.1002/j.1939-4640.1996.tb00583.x · Cited by 46
Endocrine properties of the testosterone 5α-reductase inhibitor turosteride (FCE 26073)
di Salle, E., Briatico, G., Giudici, D., Ornati, G., & Panzeri, A. (1994) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(94)90151-1 · Cited by 36
Finasteride in the treatment of patients with benign prostatic hyperplasia: a review
Carson (2009) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s6195 · Cited by 35
Male pseudohermaphroditism due to primary 5α-reductase deficiency: Variation in gender identity reversal in seven Mexican patients from five different pedigrees
Méndez, J. P., Ulloa‐Aguirre, A., Imperato‐McGinley, J., Brugmann, A., Delfin, M., Chávez, B. A., Shackleton, C. H. L., Kofman‐Alfaro, S., & Pérez‐Palacios, G. (1995) · Journal of Endocrinological Investigation · doi:10.1007/bf03347803 · Cited by 35
Self-citation
Clinical Characterization and Analysis of the SRD5A2 Gene in Six Korean Patients with 5α-Reductase Type 2 Deficiency
Ko, J. M., Cheon, C. K., Kim, G.-H., Kim, S. H., Kim, K. S., & Yoo, H. (2010) · Hormone Research in Paediatrics · doi:10.1159/000271915 · Cited by 35
5α-reductase inhibitors: what role should they play?
Kaplan, S. A. (2001) · Urology · doi:10.1016/s0090-4295(01)01347-4 · Cited by 34
Androgenic correlates of genetic variation in the gene encoding 5α-reductase type 1
Ellis, J. A., Panagiotopoulos, S., Akdeniz, A., Jerums, G., & Harrap, S. B. (2005) · Journal of Human Genetics · doi:10.1007/s10038-005-0289-x · Cited by 31
Enzyme assay for 5α-reductase Type 2 activity in the presence of 5α-reductase Type 1 activity in rat testis
Pratis, K., O’Donnell, L., Ooi, G. T., McLachlan, R. I., & Robertson, D. M. (2000) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(00)00139-4 · Cited by 33
Clinical relevance of testosterone and dihydrotestosterone metabolism in women
Rittmaster, R. S. (1995) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)80054-0 · Cited by 33
Kinetic analysis of steroid 5α-reductase activity at neutral pH in benign prostatic hyperplastic tissue: Evidence for type I isozyme activity in the human prostate
Span, P. N., Benraad, T. J., Sweep, F. C. G. J., & SMALS, A. G. H. (1996) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00167-0 · Cited by 32
Regional Distribution of 5α-Reductase Type 1 and Type 2 mRNA Along the Human Epididymis
Mahony, M. C., Swanlund, D. J., Billeter, M., Roberts, K. P., & Pryor, J. L. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00094-6 · Cited by 31
Carbon–carbon double-bond reductases in nature
Huang, M., Hu, H., Ma, L., Zhou, Q., Yu, L., & Zeng, S. (2014) · Drug Metabolism Reviews · doi:10.3109/03602532.2014.910219 · Cited by 31
In Vivo Time-Dependent Inhibition of Human Steroid 5a-Reductase by Finasteride
Tian, G. (1996) · Journal of Pharmaceutical Sciences · doi:10.1021/js950100g · Cited by 30
Pharmacological and molecular evidence for the expression of the two steroid 5α-reductase isozymes in normal and hyperplastic human prostatic cells in culture
Berthaut, I., Mestayer, C., Portois, M.-C., Cussenot, O., & Mowszowicz, I. (1997) · The Prostate · doi:10.1002/(sici)1097-0045(19970801)32:3 · Cited by 30
Stimulatory Effect of Insulin on 5α-Reductase Type 1 (SRD5A1) Expression through an Akt-Dependent Pathway in Ovarian Granulosa Cells
Kayampilly, P. P., Wanamaker, B. L., Stewart, J. A., Wagner, C. L., & Menon, K. (2010) · Endocrinology · doi:10.1210/en.2010-0444 · Cited by 29
Hypothalamo-Pituitary Unit, Testis, and Male Accessory Organs
Liu, P. Y., & Veldhuis, J. D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47912-7.00012-3 · Cited by 29
Differential Gene Expression of Steroid 5 -Reductase 2 in Core Needle Biopsies from Malignant and Benign Prostatic Tissue
Bjelfman, C., Söderström, T. G., Brekkan, E., Norlén, B. J., Egevad, L., Unge, T., Andersson, S., & Rane, A. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.7.4080 · Cited by 29
Self-citation
Age-related changes in brain and pituitary 5α-reductase with finasteride (Proscar) treatment
Lephart, E. D. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)98115-5 · Cited by 28
Genetic disorders of steroid hormone synthesis and metabolism
New, M. I., & White, P. C. (1995) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(95)80587-7 · Cited by 27
Synthesis, Biological Activity, and Three-Dimensional Quantitative Structure−Activity Relationship Model for a Series of Benzo[c]quinolizin-3-ones, Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1
Occhiato, E. G., Ferrali, A., Menchi, G., Guarna, A., Danza, G., Comerci, A., Mancina, R., Serio, M., Garotta, G., Cavalli, A., et al. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm031131o · Cited by 27
Dihydrotestosteron und die Rolle der 5α-Reduktasehemmer bei der benignen Prostatahyperplasie
Bartsch, G., Rittmaster, R. S., & Klocker, H. (2002) · Der Urologe · doi:10.1007/s00120-002-0230-2 · Cited by 27
Discovery and Development of GG745, a Potent Inhibitor of Both Isozymes of of 5α-Reductase
Frye, S. V., Bramson, H. N., Hermann, D. J., Lee, F. W., Sinhababu, A. K., & Tian, G. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-47384-4_17 · Cited by 30
Altered brain and pituitary androgen metabolism by prenatal, perinatal or pre- and postnatal finasteride, flutamide or dihydrotestosterone treatment in juvenile male rats
Lephart, E. D., & Husmann, D. A. (1993) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(93)90026-o · Cited by 27
5α-Reductase Isozymes in the Prostate.
Zhu, Y., & Sun, G. (2005) · PubMed · Cited by 26
Local Biosynthesis of Sex Steroids in Bone
Compston, J. E. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021420 · Cited by 26
AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells
Nikolaou, N., Gathercole, L., Kirkwood, L., Dunford, J. E., Hughes, B. A., Gilligan, L. C., Oppermann, U. C. T., Penning, T. M., Arlt, W., Hodson, L., et al. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.02.002 · Cited by 24
Gender Identity of Children and Young Adults with 5α-Reductase Deficiency
Praveen, E. P., Desai, A. K., Khurana, M. L., Philip, J., Eunice, M., Khadgawat, R., Kulshreshtha, B., Kucheria, K., Gupta, D. K., Seith, A., et al. (2008) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2008.21.2.173 · Cited by 29
Synthesis of the individual enantiomers of the benzoquinolinone human type 1 steroid 5-α-reductase inhibitors LY191704 and LY266111
Audia, J. E., Lawhorn, D. E., & Deeter, J. B. (1993) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)61581-2 · Cited by 25
Comparison of testosterone metabolism in benign prostatic hyperplasia and human prostate cancer cell lines in vitro
Smith, C. M., Ballard, S. A., Wyllie, M. G., & Masters, J. R. (1994) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(94)90022-1 · Cited by 25
Novel 5α-reductase inhibitors. Synthesis and structure-activity studies of 5-substituted 1-methyl-2-pyridones and 1-methyl-2-piperidones
HARTMANN, R., REICHERT, M., & Göhring, S. (1994) · European Journal of Medicinal Chemistry · doi:10.1016/0223-5234(94)90104-x · Cited by 25
The role of 5-reduction in physiology and metabolic disease: evidence from cellular, pre-clinical and human studies
Nikolaou, N., Hodson, L., & Tomlinson, J. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105808 · Cited by 26
An efficient synthesis of 3-pyridyl-N-oxide steroides: Inhibitors of 5α-reductase
Haffner, C. D. (1994) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)76215-0 · Cited by 24
A clinician looks at androgen resistance
Balducci, R., Ghirri, P., Brown, T. R., Bradford, S., Boldrini, A., Boscherini, B., Sciarra, F., & Toscano, V. (1996) · Steroids · doi:10.1016/0039-128x(96)00015-3 · Cited by 24
Medical management of benign prostatic hyperplasia
Chacon, A., & Monga, M. (1999) · Geriatric Nephrology and Urology · doi:10.1023/a:1008308819463 · Cited by 24
Benign Prostatic Hyperplasia
Jønler, M., Riehmann, M., Brinkmann, R., & Bruskewitz, R. C. (1994) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30068-9 · Cited by 23
Effects of transforming growth factor β and epidermal growth factor on steroid 5α-reductase activity in genital skin fibroblasts
Wahe, M., ANTONIPILLAI, I., & Horton, R. (1993) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(93)90236-d · Cited by 23
Effect of Finasteride on Human Testicular Steroidogenesis
Castro-Magaña, M., Angulo, M., Fuentes, B., Canas, J. A., Sarrantonio, M. J., Arguello, R., & Vitollo, P. (1996) · Journal of Andrology · doi:10.1002/j.1939-4640.1996.tb01828.x · Cited by 22
Synthesis of 4,17-diazasteroid inhibitors of human 5α-reductase
Morzycki, J. W., Łotowski, Z., Wilczewska, A. Z., & Stuart, J. D. (1996) · Bioorganic & Medicinal Chemistry · doi:10.1016/0968-0896(96)00109-5 · Cited by 23
Pilot Study of 15 Patients Receiving a New Treatment Regimen for Androgenic Alopecia: The Effects of Atopy on AGA
Rafi, A., & Katz, R. M. (2011) · ISRN Dermatology · doi:10.5402/2011/241953 · Cited by 23
Comparison between testosterone enanthate-induced azoospermia and oligozoospermia in a male contraceptive study. V. Localization of higher 5 alpha-reductase activity to the reproductive tract in oligozoospermic men administered supraphysiological doses of testosterone.
Anderson, R. A., KELLY, R. W., & Wu, F. C. W. (1997) · PubMed · Cited by 22
Microbial transformations of testosterone to 5α-dihydrotestosterone by two species of Penicillium: P. chrysogenum and P. crustosum
Cabeza, M. S. P., Gutiérrez, E., Garcı́a, G., Avalos, A. H., & Espinosa, M. Á. H. (1999) · Steroids · doi:10.1016/s0039-128x(98)00115-9 · Cited by 21
Steroids with a carbamate function at C-17, a novel class of inhibitors for human and hamster steroid 5α-reductase
Bratoeff, E., Sainz, T., Cabeza, M., Heuze, I., Recillas‐Morales, S., Pérez, V., Rodríguez, C., Segura, T., Gonzales, J. C. Z., & Ramı́rez, E. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.03.038 · Cited by 21
5α-reductase and 17β-hydroxysteroid dehydrogenase expression in epithelial cells from hyperplastic and malignant human prostate
Délos, S., Carsol, J.-L., Fina, F., Raynaud, J., & Martin, P. (1998) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19980316)75:6 · Cited by 21
Abnormal p53 expression is rare in clinically localized human prostate cancer: Comparison between immunohistochemical and molecular detection of p53 mutations
Mottaz, A. E., Markwalder, R. V., Fey, M. F., Klima, I., Merz, V. W., Thalmann, G. N., Ball, R. K., & Studer, U. E. (1997) · The Prostate · doi:10.1002/(sici)1097-0045(19970601)31:4 · Cited by 32

Authors: Jenkins, E. P., Andersson, S., Imperato-McGinley, J., Wilson, J. D., & Russell, D. W.
Affiliations: The University of Texas Southwestern Medical Center (US)
Cornell University (US)
ORCID: Russell, D W
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1992-01-01
Volume: 89
Issue: 1
Pages: 293-300
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci115574
PMC: PMC442847
OpenAlex: W1974392957
Cited by: 395
References: 32
Citations by year: 2026: 2 · 2024: 6 · 2023: 15 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 6 · 2015: 8 · 2014: 5 · 2013: 11 · 2012: 8
FWCI: 11.26
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Welch Foundation (I-0971)
National Institutes of Health (5r01gm043753-07, 5r01dk003892-40)
National Institute of General Medical Sciences (GM-43753)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-03892, DK-07307, T32DK007307)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords: 5α-reductase, isozymes, dihydrotestosterone, 5-alpha-reductase deficiency, 46,XY disorders of sex development, finasteride, enzyme inhibition, pH optimum, cDNA, androgen production
MeSH terms: Base Sequence, Cloning, Molecular, DNA, Single-Stranded, Humans, Isoenzymes, Kinetics, Male, Molecular Sequence Data, Pedigree, Prostate, Polymorphism, Restriction Fragment Length, Disorders of Sex Development, Skin, Dihydrotestosterone, Testosterone, 3-Oxo-5-alpha-Steroid 4-Dehydrogenase, Polymerase Chain Reaction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Genetic and pharmacological evidence for more than one human steroid 5 alpha-reductase.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks