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Cited by 287

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion.

Open access
Tsai, S L, Chen, P J, Lai, M Y, Yang, P M, Sung, J L, Huang, J H, Hwang, L H, Chang, T H, Chen, D S·1992·Journal of Clinical Investigation
DOI 10.1172/jci115590
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Abstract

T cell proliferative responses to hepatitis B virus-encoded envelope antigen (S + preS2 + preS1), recombinant core antigen (HBcAg), and natural hepatitis B e antigen (HBeAg) were examined in 22 HBeAg-positive patients with chronic type B hepatitis and 17 healthy hepatitis B surface antigen (HBsAg) carriers. The results showed that HBeAg-positive patients had (a) higher levels of T cell responses to HBcAg/HBeAg than those of healthy HBsAg carriers (P less than 0.001 and P less than 0.01, respectively); (b) a further increase in these T cell responses during acute exacerbations (P less than 0.05 and P less than 0.05, respectively); (c) subsidence in the T cell responses to HBcAg/HBeAg after recovery from acute exacerbations and HBeAg seroconversion, whereas the responses would persist at high levels if the patients did not enter a clinical remission; and (d) low levels of T cell responses to S + preS2 + preS1 either before or after HBeAg seroconversion. The appearance of increasing T cell responses to HBcAg/HBeAg usually occurred in the early phase of acute exacerbations. These findings imply that HBcAg/HBeAg-specific T cells play an important role in the exacerbations of chronic hepatitis B and in HBeAg seroconversion. HBcAg/HBeAg-specific precursor T cell frequencies were serially studied in selected cases by limiting dilution assay. Elevation (two- to fourfold) of HBcAg/HBeAg-specific precursor T cell frequencies contributed to the increase of HBcAg/HBeAg-specific T cell proliferation during acute exacerbations.

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Metadata

Authors
Tsai, S. L., Chen, P. J., Lai, M. Y., Yang, P. M., Sung, J. L., Huang, J. H., Hwang, L. H., Chang, T. H., & Chen, D. S.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1992-01-01
Volume
89
Issue
1
Pages
87-96
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci115590
OpenAlex
W2107451615
Cited by
287
References
24
FWCI
11.75
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion. https://app.cochat.ai/papers/10.1172/jci115590
The paper
Tsai, S. L., Chen, P. J., Lai, M. Y., Yang, P. M., Sung, J. L., Huang, J. H., Hwang, L. H., Chang, T. H., & Chen, D. S. (1992). Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion. Journal of Clinical Investigation. https://doi.org/10.1172/jci115590

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.